Results 61 to 70 of about 12,152 (205)

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Mifepristone 2.5 mg versus 5 mg daily in the treatment of leiomyoma before surgery [PDF]

, 2012
Josep L Carbonell Esteve1, Ana M Riverón2, Mariela Cano2, Alma I Ortiz3, Aleta Valle2, Carlos S Texidó2, Giuseppe Tomasi41Mediterránea Médica Clinic, Valencia, Spain; 2Eusebio Hernández Obstetrics ...
Ortiz AI, Cano M, Carbonell Esteve JL, Riverón AM, Valle A, Texidó CS, Tomasi G   +6 more
core  

Neuroprotective effect of mifepristone involves neuron depolarization [PDF]

, 2006
International audienceIn several regions of the developing nervous system, neurons undergo programmed cell death. In the rat cerebellum, Purkinje cell apoptosis is exacerbated when cerebellar slices are cultured during the first postnatal week.
Schumacher, M., Ghoumari, A.M., Eychenne, B., Levenes, C., Piochon, C., Dusart, I., Tomkiewicz, C., Levenes, Carole, Baulieu, E.   +8 more
core   +1 more source

Importance of Hypercortisolism in BP Control, Cardiovascular Risk and in Patients With Difficult‐to‐Control Hypertension: An Overview for Primary Care Physicians

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Hypertension remains one of the most prevalent and consequential modifiable cardiovascular risk factors worldwide, affecting approximately 1.28 billion adults globally and nearly half of the United States population. Despite the availability of effective therapies, optimal blood pressure control is achieved in fewer than one in four ...
Matthew A. Cavender
wiley   +1 more source

Evaluation of Early Medical Abortion (EMA) pilot sites [PDF]

, 2008
This DH commissioned research assessed the safety, effectiveness and acceptability of early medical abortions in non-traditional settings, and will contribute towards the establishment of a protocol to cover the elements and processes required for a safe
Lee, Ellie, Lee, Ellie J., Ingham, Roger
core  

Effects of the glucocorticoid antagonist, mifepristone, on the consequences of withdrawal from long term alcohol consumption [PDF]

, 2008
BACKGROUND: Studies were carried out to test the hypothesis that administration of a glucocorticoid Type II receptor antagonist, mifepristone (RU38486), just prior to withdrawal from chronic alcohol treatment, would prevent the consequences of the ...
Croft, Adam P., Mulholland, Patrick, Little, Hilary, Prendergast, Mark A., Jacquot, Catherine, Prendergast, Mark A, Croft, Adam P, Shaw, Sidney G, Little, Hilary J., Shaw, Sidney G., Croft, Adam P.; id_orcid, Little, Hilary J   +11 more
core   +1 more source

Mifepristone followed by misoprostol compared with placebo followed by misoprostol as medical treatment for early pregnancy loss (the Triple M trial): A double-blind placebo-controlled randomised trial

EClinicalMedicine, 2021
Background: Worldwide, millions of women seek treatment for early pregnancy loss (EPL) annually. Medical management with misoprostol is widely used, but only effective 60% of the time.
Charlotte Hamel, Sjors Coppus, Joyce van den Berg, Esther Hink, Jacoba van Seeters, Paul van Kesteren, Ashley Merién, Bas Torrenga, Rafli van de Laar, Josien Terwisscha van Scheltinga, Ingrid Gaugler-Senden, Peppino Graziosi, Minouche van Rumste, Ewka Nelissen, Frank Vandenbussche, Marcus Snijders   +15 more
doaj   +1 more source

How Common Is Hypercortisolism in Patients With Hypertension? Risk Factors, Epidemiology, and Making a Diagnosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Endogenous hypercortisolism (EHC) is an underrecognised and clinically significant contributor to hypertension, particularly resistant hypertension. Once viewed as a rare entity, EHC is now understood as a spectrum of cortisol excess associated with adverse cardiometabolic outcomes and target‐organ damage.
Omar Al Dhaybi, Deepak L. Bhatt
wiley   +1 more source

British Abortion Law: Speaking from the Past to Govern the Future [PDF]

, 2016
This paper analyses the poor alignment of the aging statutory framework and modern understandings of medical best practice in the context of abortion services.
Sheldon, S., Sheldon, Sally
core   +1 more source

Is Hypercortisolism Treatable? Which Patients Should Be Treated and How—A Practical Guide for Clinicians

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To provide a practical guide on when to suspect endogenous hypercortisolism, how to use the overnight 1‐mg dexamethasone suppression test (DST) for targeted case‐finding, and which patients are most likely to benefit from treatment.
Juan Pablo Frias
wiley   +1 more source