Results 61 to 70 of about 187,461 (293)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

South Africa Case Study: The Double Crisis – Mass Migration From Zimbabwe And Xenophobic Violence in South Africa [PDF]

open access: yes, 2017
The protracted economic and political crisis in Zimbabwe led directly to a major increase in mixed migration flows to South Africa. Migrants were drawn from every sector of society, all education and skill levels, equal numbers of both sexes, and all ...
Chikanda, Abel   +4 more
core   +1 more source

Political and Media Discourses about Integrating Refugees in the UK [PDF]

open access: yes, 2019
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.This article addresses political and media discourses about integrating refugees in the UK in the context ...
Billig M.   +7 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

THE INFLUENCE OF THE MIGRANT CRISIS ON TERRORISM IN EUROPE

open access: yesPravo, 2017
THE subject of this research refers to the influence of the migrant crisis on terrorism in Europe. Recently, we have been the witnesses of the increased terrorism on the territory of Europe, especially the one that has found its basis in religious ...
Dragan Pašić
doaj  

Interdisciplinary Teaching About Refugee and Migrant Policy and Experiences Using Simulation and Story

open access: yesTeaching & Learning Inquiry: The ISSOTL Journal
This research assesses how interdisciplinary pedagogical interventions can prepare students to tackle complex problems, such as the refugee and migrant crisis.
Emily Wierszewski, Roni Kay O'Dell
doaj   +1 more source

Immense Risks: the Migrant Crisis, Magical Realism, and Realist “Magic” in Mohsin Hamid’s Novel Exit West [PDF]

open access: yesPolish Journal of English Studies, 2020
The aim of this paper is to analyse Mohsin Hamid’s 2017 Exit Westas a literary response to the 2015 migrant crisis. Hamid’s fourth novel will be shown as, on the one hand, a formal departure from his previous works, but on the other, a ...
Ewa Kowal
doaj  

Passeurs: Narratives of Border Crossing in the Western Alps [PDF]

open access: yes, 2019
This article focuses on representations of passeurs: migrant smugglers across the French-Italian and Swiss-Italian borders. I analyze a heterogeneous corpus of novels, films, and essays published between 1990-2017 that refer to different waves of ...
Di Blasio, Federica
core  

Matryoshka journeys: im/mobility during migration [PDF]

open access: yes, 2016
Acts of mobility require corresponding acts of immobility (or suspended mobility). Migrant journeys are not only about movement. Indeed, in the present policy context, this is ever more true.
Brigden, Noelle, Mainwaring, Ċetta
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

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