Results 51 to 60 of about 644,817 (218)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Migration processes in modern Russia and their impact on economic and national security
Экономика и управлениеAim. This work aimed to analyze data on migration processes in modern Russia, their manifestations, and their impact on the country’s economic and national security, as well as to identify associated risks and threats and consider existing opportunities ...
N. A. Rykov, A. V. Golubev
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Geostrategy at the EU’s South-Eastern Gate
Управленческое консультирование, 2018 The study presents the geostrategic causes of Asian and African migration to Europe since 2015. Illustrated with maps and technical border protection data, it presents the Hungarian government’s response measures and its effects, with particular regard ...
I. Tózsa, J. Sallai
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Possible Scenarios of Development of Migration Processes in the Context of Eurasian Integration
Международная аналитика, 2019 The article talks about migration processes in the post-Soviet space in the context of Eurasian integration. It is noted that recently, due to the natural population decline in Russia, migration is one of the mechanisms for compensating for demographic ...
A. A. Kazantsev, L. Yu. Gusev
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Модернизация, инновация, развитие, 2016 The article examines trends in labour migration in the Russian Federation. Analyzed the migration of communications of Russia in the 1st quarter 2014 and 2015, Examines the impact of increasing migration fl ows of citizens of Ukraine on the state of the ...
E. D. Katulskij
doaj +1 more source
Polyhedral Ferraboranes with Iron Carbonyl Vertices: Carbonyl Migration Processes in the Iron Tetracarbonyl Derivatives. [PDF]
J Phys Chem A, 2023 Attia AAA, Lupan A, King RB.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source