Results 111 to 120 of about 482,563 (349)

Habitual physical activity (HPA) as a factor in sustained executive function in Alzheimer-type dementia: a cohort study [PDF]

, 2014
Evidence from studies on healthy older adults and mild cognitive impairment (MCI) populations suggests that physical activity interventions have a positive effect on executive function. In this study, we consider whether HPA is positively associated with
Alexopoulos, Angevaren, Army Individual Test Battery, Binetti, Bingham, Bixby, Boyle, Bruce, Burns, Burns, Cade, Caspersen, Clifford, Colcombe, Collette, Cummings, Farina, Folstein, Gates, Glosser, Harada, Hillman, Honea, Jennifer Rusted, Kramer, Lezak, Lubben, Lubben, Mioshi, Miyake, Naji Tabet, Nicolas Farina, Nykänen, Pate, Pivarnik, Plasqui, Prince, Rantanen, Razani, Robertson, Ruiz-López, Rusted, Ruthirakuhan, Sattler, Schinka, Schinka, Sgaramella, Smiley-Oyen, Smith, Spreen, Storandt, Strauss, Swanberg, Trichopoulou, Tucker, Van der Bij, Vidoni, Washburn, Washburn, Washburn, Wecshler, Wilson, Winchester, Yasunaga, Yu   +64 more
core   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

The Differentiation of Amnestic Type MCI from the Non-Amnestic Types by Structural MRI [PDF]

, 2016
INTRODUCTION: While amnestic mild cognitive impairment (aMCI) and non-amnestic mild cognitive impairment (naMCI) are theoretically different entities, only a few investigations studied the structural brain differences between these subtypes of mild ...
András eHorváth, Enikő eSirály, Gábor eCsukly, Gábor eRudas, Pál eSalacz, Pál eSalacz, Zoltán eHidasi, Zsuzsanna eFodor, Ádám eSzabó, Éva eCsibri   +9 more
core   +2 more sources

Bibliometric analysis of research trends on factors affecting older adults with mild cognitive impairment

Frontiers in Neurology
BackgroundIn recent years, the problem of cognitive impairment in the elderly has become increasingly prominent. Understanding the research trend of influencing factors of mild cognitive impairment, and provide reference for medical staff to early ...
Lei Yang, Rushi Yang, Bo Wang, Tiantian Liu, Ziyi Wang   +4 more
doaj   +1 more source

Exercise-related changes of networks in aging and mild cognitive impairment brain

Frontiers in Aging Neuroscience, 2016
Aging and mild cognitive impairment are accompanied by decline of cognitive functions. Meanwhile, the most common form of dementia is Alzheimer’s disease, which is characterized by loss of memory and other intellectual abilities serious to make ...
Pei eHuang, Rong eFang, Binyin eLi, Sheng-di eChen   +3 more
doaj   +1 more source

Genetics‐Based Targeting Strategies for Precise Neuromodulation

Advanced Science, EarlyView.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He, Zhidong Wei, Jianda Xu, Fei Jin, Tong Li, Lili Qian, Juan Ma, Weiying Zheng, Negar Javanmardi, Ting Wang, Kangjian Sun, Zhang‐Qi Feng   +11 more
wiley   +1 more source

Souvenaid in the Management of Mild Cognitive Impairment: An Expert Consensus Opinion [PDF]

, 2019
Background Mild cognitive impairment (MCI) among an aging global population is a growing challenge for healthcare providers and payers. In many cases, MCI is an ominous portent for dementia.
Bertolucci, Paulo, Cappa, Stefano, Chen, Christopher, Chu, Leung-Wing, Cummings, Jeffrey, Engelborghs, Sebastiaan, Garcia-Ribas, Guillermo, Manzano, Sagrario, McGuinness, Bernadette, Mok, Vincent, Passmore, Peter, Woodward, Michael   +11 more
core   +3 more sources

Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease

Advanced Science, EarlyView.
This study presents the NEV β‐secretase activity assay, a groundbreaking method for noninvasive evaluation of β‐secretase activity in Alzheimer's disease (AD) patients, enabling the generation of individualized β‐secretase activity profiles.
Hyoyong Kim, Junseok Lee, Audrey Qian, You‐Ren Ji, Ryan Zhang, Qixin Hu, Christopher Kazu Williams, Han‐Yu Chuang, Matthew D. Smalley, Yaya Xu, Liang Gao, Mary C. Mayo, Ting Zhang, Edwin M. Posadas, Zaldy S. Tan, Harry V. Vinters, Keith Vossel, Shino Magaki, Yazhen Zhu, Hsian‐Rong Tseng   +19 more
wiley   +1 more source

Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts

Advanced Science, EarlyView.
Jin et al. investigate the neurovascular impact of microinfarcts, revealing transient neural suppression with minimal cell death and recovery linked to vascular remodeling. Fast‐spiking interneurons exhibit reduced excitability, whereas regular‐spiking neurons showed increased bursting activity. Disruptions in low‐gamma phase locking suggest persistent
Yifu Jin, Fei He, Haad Rathore, Yingchu Sun, Jia‐ao Zhang, Xinyu Li, Rongkang Yin, Hanlin Zhu, Chong Xie, Lan Luan   +9 more
wiley   +1 more source

Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease [PDF]

, 2000
Kejal Kantarci, Clifford R. Jack, Yun Xu, Norberg G. Campeau, Peter C. O’Brien, Glenn E. Smith, Robert J. Ivnik, Bradley F. Boeve, E. Kokmen, Eric G. Tangalos, R. C. Petersen   +10 more
openalex   +1 more source