Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts
Advanced Science, EarlyView.Jin et al. investigate the neurovascular impact of microinfarcts, revealing transient neural suppression with minimal cell death and recovery linked to vascular remodeling. Fast‐spiking interneurons exhibit reduced excitability, whereas regular‐spiking neurons showed increased bursting activity. Disruptions in low‐gamma phase locking suggest persistent
Yifu Jin +9 more
wiley +1 more source
Federated Learning for Predicting Mild Cognitive Impairment to Dementia Conversion [PDF]
arXivDementia is a progressive condition that impairs an individual's cognitive health and daily functioning, with mild cognitive impairment (MCI) often serving as its precursor. The prediction of MCI to dementia conversion has been well studied, but previous studies have almost always focused on traditional Machine Learning (ML) based methods that require ...
arxiv
Mild Cognitive Impairment and Alzheimer Disease: Regional Diffusivity of Water [PDF]
, 2001 Kejal Kantarci +10 more
openalex +1 more source
Advanced Science, EarlyView.A novel “prof” cocktail therapy is designed. It screens antigens, selects personalized antigen panels, engineers optimized CAR‐Vδ1 T cells, and tests in patient‐derived GBM organoids, offering hope for effective CAR‐T drugs against heterogeneous solid tumors. Abstract Various challenges, including tumor heterogeneity and inadequate T cell infiltration,
Guidong Zhu +12 more
wiley +1 more source
Sentence Segmentation in Narrative Transcripts from Neuropsychological Tests using Recurrent Convolutional Neural Networks [PDF]
arXiv, 2016 Automated discourse analysis tools based on Natural Language Processing (NLP) aiming at the diagnosis of language-impairing dementias generally extract several textual metrics of narrative transcripts. However, the absence of sentence boundary segmentation in the transcripts prevents the direct application of NLP methods which rely on these marks to ...
arxiv
A Pilot Study on the Comparison of Prefrontal Cortex Activities of Robotic Therapies on Elderly with Mild Cognitive Impairment [PDF]
arXivDemographic shifts have led to an increase in mild cognitive impairment (MCI), and this study investigates the effects of cognitive training (CT) and reminiscence therapy (RT) conducted by humans or socially assistive robots (SARs) on prefrontal cortex activation in elderly individuals with MCI, aiming to determine the most effective therapy-modality ...
arxiv
Is Mild Cognitive Impairment Prodromal for Vascular Dementia Like Alzheimer’s Disease? [PDF]
, 2002 John Stirling Meyer +4 more
openalex +1 more source
Contemporary Clinical Trials Communications, 2019 Non-pharmacological interventions designed to change cognitive function in older adults with Mild Cognitive Impairment have shown mixed results. Few studied interventions directly address preclinical disability. Slowing changes in disability are critical
Juleen Rodakowski +6 more
doaj
HDL‐Apolipoprotein in Alzheimer's Disease Revisited: From Periphery to CNS
AGING MEDICINE, EarlyView.HDL‐apolipoproteins in the periphery and CNS contribute differently to Alzheimer's disease, influencing Aβ, p‐tau, brain structures, and cognition. Apolipoprotein AI and E, key HDL components in blood and CSF, may either protect against or accelerate AD, depending on their location. Created with BioGDP.com. ABSTRACT High‐density lipoprotein (HDL), as a
Yihong Huang +8 more
wiley +1 more source
Evaluating GPT's Capability in Identifying Stages of Cognitive Impairment from Electronic Health Data [PDF]
arXivIdentifying cognitive impairment within electronic health records (EHRs) is crucial not only for timely diagnoses but also for facilitating research. Information about cognitive impairment often exists within unstructured clinician notes in EHRs, but manual chart reviews are both time-consuming and error-prone.
arxiv