Results 171 to 180 of about 792,865 (388)
Is Mild Cognitive Impairment Prodromal for Vascular Dementia Like Alzheimer’s Disease? [PDF]
John Stirling Meyer+4 more
openalex +1 more source
Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia
Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji+12 more
wiley +1 more source
Yu-Wen Cheng,1 Ta-Fu Chen,2 Ming-Jang Chiu2,3 1Department of Neurology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan; 2Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan ...
Cheng YW, Chen TF, Chiu MJ
doaj
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma+10 more
wiley +1 more source
Challenging assumptions about Alzheimer's disease: Mild cognitive impairment and the cholinergic hypothesis [PDF]
John C. Morris
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Alzheimer’s disease (AD) is a progressive disease leading to cognitive decline, and to prevent it, researchers seek to diagnose mild cognitive impairment (MCI) early.
Seul-Kee Kim+4 more
doaj +1 more source
Mild cognitive impairment as a diagnostic entity
R. Petersen
semanticscholar +1 more source
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi+15 more
wiley +1 more source
FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou+8 more
wiley +1 more source
Increased Risk of Cognitive Impairment 3 Months After Mild to Moderate First-Ever Stroke [PDF]
Velandai Srikanth+6 more
openalex +1 more source