Results 191 to 200 of about 2,881,091 (302)

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Hippocampal-striatal interaction in Parkinson's disease with mild cognitive impairment. [PDF]

Clin Park Relat Disord
Xu J, Tan S, Zhang X, Zhang M, Xu X.
europepmc   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Non-pharmacological interventions for older adults with mild cognitive impairment: an umbrella review. [PDF]

BMC Geriatr
Tiga-Loza DC, Urrea-Vega EA, Rivera-Carvajal R, Alvarez-Anaya WA, Buitrago-Buitrago JA, Hernández-Martínez AM, Camacho-López PA.   +6 more
europepmc   +1 more source

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

Mild Cognitive Impairment Diagnosis and Care Algorithms and the Role of Digital Interventions: Expert Consensus. [PDF]

CNS Neurosci Ther
Kandiah N, Chan YF, Dasig D, Dominguez J, Koh KC, Lim SC, Ong PA, Raya-Ampil E, Seet RCS, Senanarong V, Tan KM, Tan MP, Thắng TC, Trang TM, Turana Y, Wei C, Ihl R.   +16 more
europepmc   +1 more source

Temporal‐Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial

Advanced Science, EarlyView.
Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo, Xingxing Li, Chenjun Zou, Chao Zheng, Xiaohong Wu, Xuechao Lu, Jiaying Yan, Junfang Zhang, Xiaoyan Luo, Shiwei Ye, Dongsheng Zhou   +10 more
wiley   +1 more source

Hearing Intervention for Older Adults With Mild Cognitive Impairment: The CHOICE Randomized Clinical Trial.

JAMA Neurol
Chen Y, Shi H, Xiang M, Li X, Wang Z, Lu W, Shen Y, Fang Y, Chen J, Guan L, Zhao F, Wu Z, Tian R, Yu Q, Han K, Sheng H, Chen S, Sun J, Liu G, Wu H, CHOICE Collaborative Research Group.   +20 more
europepmc   +1 more source

White matter microstructure and motor function in amnestic mild cognitive impairment and Alzheimer's dementia. [PDF]

Neuroimage Rep
Cote S, Ruitenberg MFL, van der Geest JN, Frost NA, King JB, Duff K, Koppelmans V.   +6 more
europepmc   +1 more source

Brain Network Dynamics of Local and Global Predictive Processing in Aging

Advanced Science, EarlyView.
Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen, Gemma Fernández‐Rubio, David R. Quiroga‐Martinez, Mattia Rosso, Mathias Klarlund, Kit Melissa Larsen, Hartwig Roman Siebner, Morten L. Kringelbach, Peter Vuust, Leonardo Bonetti   +9 more
wiley   +1 more source