Results 191 to 200 of about 483,719 (279)

Reduced CB1 Cannabinoid Receptor Expression in Alzheimer's Disease and Transgenic Mouse Models

AGING MEDICINE, EarlyView.
CB1 receptor (CB1R) expression was significantly reduced in the hippocampus, medial frontal gyrus, and superior temporal gyrus of Alzheimer's patients. CB1R levels negatively correlated with amyloid‐β and tau pathology. In addition, CB1R expression was also reduced in the cortex of 5xFAD mice and in the hippocampus of Tg4‐42 mice.
Nike von Borcke, Amrei Vivian Purwien, Annik Steiert, Henrike Hasecke, Yvonne Bouter   +4 more
wiley   +1 more source

Clinical Characteristics of Geriatric Asthma in Guangxi of China: A Retrospective Comparative Descriptive Study

AGING MEDICINE, EarlyView.
Geriatric asthmatics exhibit more comorbidities, poorer lung function, higher neutrophil ratios, and elevated CRP levels. ABSTRACT Objective The research analyzed the clinical characteristics of geriatric and nongeriatric asthma cases, aiming to provide new insights into the diagnosis and management of geriatric asthma for clinicians.
Mengxia Gu, Qixiang Sun, Yujia Huang, Yuetian Deng, Xiaohong Jiang   +4 more
wiley   +1 more source

Perioperative and Oncological Outcomes of Colorectal Cancer Surgery in Obese Patients: A Multicenter Retrospective Study

Annals of Gastroenterological Surgery, EarlyView.
The prognostic value of the log odds of positive lymph nodes (LODDS) across BMI categories was investigated in patients undergoing colorectal cancer resection. The exploratory evidence demonstrates that LODDS serves as a strong prognostic marker, and its adverse effect may be more pronounced in patients with higher BMI.
Kazuhiro Taguchi, Manabu Shimomura, Wataru Shimizu, Satoshi Ikeda, Masanori Yoshimitsu, Mohei Kouyama, Masahiro Nakahara, Hironori Kobayashi, Masatoshi Kochi, Yosuke Shimizu, Daisuke Sumitani, Shoichiro Mukai, Yuji Takakura, Yasuyo Ishizaki, Shinya Kodama, Masahiko Fujimori, Hiroshi Okuda, Takuya Yano, Tomoaki Bekki, Atsuhiro Watanabe, Saki Sato, Toshiyuki Moriuchi, Shohei Shiozaki, Kazuki Matsubara, Mizuki Yamaguchi, Tomohiro Adachi, Sho Ishikawa, Hideki Ohdan   +27 more
wiley   +1 more source

Psoas Muscle Volume as a Predictor of Postoperative Complications in Patients Undergoing Emergency Surgery for Strangulated Small Bowel Obstruction: A Retrospective Single‐Center Study

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study identified low preoperative psoas muscle volume, measured by computed tomography, as an independent predictor of postoperative complications in patients undergoing emergency surgery for strangulated small bowel obstruction. Low psoas muscle volume, particularly in older adults, was associated with cardiopulmonary and systemic ...
Takuya Shiraishi, Chika Katayama, Yuta Shibasaki, Chika Komine, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Hiroomi Ogawa, Ken Shirabe, Hiroshi Saeki   +9 more
wiley   +1 more source

Short‐Term Outcomes and Cost Drivers of Emergency Surgery for Acute Abdominal Disease in Super‐Elderly Patients: A Study in the Japanese Tertiary Care Hospital

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study analyzed patients aged ≥ 85 years undergoing emergency abdominal surgery, focusing on short‐term outcomes and inpatient cost structure under the Japanese DPC system. Although major complications occurred in 19.4% of patients, more than 70% were discharged home.
Yuta Kobayashi, Ryo Oikawa, Yumi Shibuya, Masakazu Tatsuno, Atsuya Kamiyama, Tsuyoshi Ozawa, Keiichiro Hara, Shojiro Hata, Hirokazu Yamaguchi   +8 more
wiley   +1 more source

Giving and receiving help in three contexts as predictors of alcohol outcomes in a longitudinal study of sober living house residents

American Journal of Community Psychology, EarlyView.
Abstract Although peer support is central to the social model approach emphasized in sober living houses (SLHs), no longitudinal studies have examined helping among SLH residents. This longitudinal study examined benefits of helping in three contexts among SLH residents. Data were from 205 participants entering 28 SLHs across 2021–2023. Interviews were
Sarah E. Zemore, Elizabeth Mahoney, Meenakshi S. Subbaraman, Amy A. Mericle, Douglas L. Polcin   +4 more
wiley   +1 more source

Clinical Insights From a Case of Sifrim‐Hitz‐Weiss Syndrome With a CHD4 Variant: Expanding the Phenotypic Spectrum and Its Response to Growth Hormone Therapy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT To enhance clinicians' understanding of Sifrim‐Hitz‐Weiss syndrome (SIHIWES), this study investigated the clinical phenotypes, genetic characteristics, and response to growth hormone therapy in a patient. A case of a patient with global developmental delay and distinctive facial features is presented.
Jianmei Zhang, Shuangzhong Chen, Guanping Dong, Suhong Yang, Ping Wang, Qiong Zhou, Pingping Wang   +6 more
wiley   +1 more source

Swallowing and Communication in Cockayne Syndrome: Clinical Characteristics and Management

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cockayne syndrome (CS) is an ultrarare genetic disorder associated with genes encoding proteins involved in DNA repair. The clinical course of CS involves neurodevelopmental and neurodegenerative features, including swallowing and communication impairments.
Abigail M. Spoden, Katlyn E. McGrattan, Peter B. Kang   +2 more
wiley   +1 more source

Gastrointestinal Manifestations in Rubinstein‐Taybi Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Rubinstein–Taybi syndrome is a rare genetic condition associated with a wide range of physical, cognitive, and developmental impairments, yet its gastrointestinal manifestations remain poorly characterized. Case reports and small series suggest a high prevalence of gastroesophageal reflux, constipation, dysphagia, and nutritional compromise ...
Mohamad Abi Nassif, Ajay Kaul, Lev Dorfman, Khalil El‐Chammas   +3 more
wiley   +1 more source

Remote Language Assessment in School‐Age Children With Phelan–McDermid Syndrome and Genotype–Phenotype Correlation

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT People with Phelan–McDermid syndrome (PMS) have reduced speech and language abilities, yet little research has profiled the communication abilities in this population. The purpose of this study was threefold: identifying the language and communication profiles of school‐aged children with PMS, identifying genetic contributions to language and ...
Sarah Quadri‐Valverde, Jessica Klusek, Linda D. Ward, Diana Ivankovic, Nancy Powers, Vijay Shankar, Rachel A. Lyman, Trudy F. C. Mackay, William Bridges, Katy Phelan, Curtis Rogers, Luigi Boccuto, Sara M. Sarasua   +12 more
wiley   +1 more source