Results 71 to 80 of about 482,563 (349)

HPDL Variant Type Correlates With Clinical Disease Onset and Severity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recently, a mitochondrial encephalopathy due to biallelic HPDL variants was described, associated with a broad range of clinical manifestations ranging from severe, infantile‐onset neurodegeneration to adolescence‐onset hereditary spastic paraplegia. HPDL converts 4‐hydroxyphenylpyruvate acid (4‐HPPA) into 4‐hydroxymandelate (4‐HMA),
Eun Hye Lee, Olivia Kim‐Mcmanus, Jennifer H. Yang, Richard Haas, Maha S. Zaki, Ghada M. H. Abdel‐Salam, Yuji Nakamura, Mohamed S. Abdel‐Hamind, Darius Ebrahimi‐Fakhari, Julian E. Alecu, Nicola Brunetti‐Pierri, Varunvenkat M. Srinivasan, Vykuntaraju K. Gowda, Stephanie Gross, Yasemin Alanay, Paria Najarzadeh Totbati, Manya Yadavilli, Liana Friedman, Naomi Meave Ojeda, Joseph G. Gleeson   +19 more
wiley   +1 more source

Semantic Memory Functional MRI and Cognitive Function After Exercise Intervention in Mild Cognitive Impairment [PDF]

, 2013
Mild cognitive impairment (MCI) is associated with early memory loss, Alzheimer\u27s disease (AD) neuropathology, inefficient or ineffective neural processing, and increased risk for AD.
Antuono, Piero, Butts, Alissa, Hanson, Ryan J., Hantke, Nathan, Lyons, Jeri-Annette, Nielson, Kristy A., Smith, J Carson, Verber, Matthew D.   +7 more
core   +2 more sources

MCI, en dan? De toekomst van 'mild cognitive impairment'

Tijdschrift voor Gerontologie en Geriatrie, 2014
Bespreking: Belleville, S., Gauthier, S., Lepage, E., Kergoat, M.J. & Gilbert, B. (2014). Predicting decline in mild cognitive impairment: a prospective cognitive study. Neuropsychology, 28, 643–652.
Han F.A. Diesfeldt
doaj   +1 more source

Threshold Values of Sleep Spindles Features in Healthy Adults Using Scalp‐EEG and Associations With Sleep Parameters

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sleep spindles are an electrophysiological fingerprint of the sleeping human brain. They can be described in terms of duration, frequency, amplitude, and density, and vary widely according to age and sex. Spindles play a role in sleep and wake functions and are altered in several neurological and psychiatric disorders.
Julien Coelho, Heloïse Degros, Jean‐Arthur Micoulaud‐Franchi, Patricia Sagaspe, Emmanuel d'Incau, Paul Galvez, Christian Berthomier, Pierre Philip, Jacques Taillard   +8 more
wiley   +1 more source

Cognitive reserve and AβI-42 in mild cognitive impairment (Argentina-Alzheimer’s disease neuroimaging initiative) [PDF]

, 2015
Background: The purpose of this study was to investigate the relationship between cognitive reserve and concentration of Aβ1-42 in the cerebrospinal fluid (CSF) of patients with mild cognitive impairment, those with Alzheimer’s disease, and in control ...
Allegri, Ricardo Francisco, Campos, Jorge, Chrem Mendez, Patricio Alexis, Clarens, María Florencia, Guinjoan, Salvador Martín, Harris, Paula, Martín, María Eugenia, Russo, María Julieta, Sevlever, Gustavo, Suarez, Marcos Fernandez, Surace, Ezequiel Ignacio, Tapajoz Pereira de Sampaio, Fernanda   +11 more
core   +2 more sources

Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States

SAGE Open Medicine
Background: Sleep is a multifaceted phenomenon influenced by both duration and quality. Various sleep disturbances have been associated with mild cognitive impairment, but the role of specific disturbances in mild cognitive impairment pathophysiology ...
Chan Shen, Hao Wang, Arthur Nguimatsa Djiotsop, R. Constance Wiener, Mona Pathak, Sophie Mitra, Patricia A Findley, Usha Sambamoorthi   +7 more
doaj   +1 more source

Cognitive function in patients undergoing cystectomy for bladder cancer – results from a prospective observational study

Therapeutic Advances in Urology, 2022
Background: Impaired cognitive function of bladder cancer patients plays a role in coping with the kind of urinary diversion and may impact perioperative morbidity. In this study we therefore aimed to assess the prevalence of mild cognitive impairment in
Camilla M. Grunewald, Vera Feldmeier, Tillmann Supprian, Peter Albers, Markus Giessing, Günter Niegisch   +5 more
doaj   +1 more source

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden, Charles Carron, Donatienne Van Weehaeghe, Joke De Vocht, Fouke Ombelet, Pegah Masrori, Caro De Weerdt, Rebecca E. James, Lauren T. Evans, Frederick A. Schroeder, Jacob M. Hooker, Michel Koole, Janice E. Kranz, Tonya M. Gilbert, Philip Van Damme, Koen Van Laere   +15 more
wiley   +1 more source

Does Physical Activity Influence Semantic Memory Activation in Amnestic Mild Cognitive Impairment? [PDF]

, 2011
The effect of physical activity (PA) on functional brain activation for semantic memory in amnestic mild cognitive impairment (aMCI) was examined using event-related functional magnetic resonance imaging during fame discrimination.
Antuono, Piero, Butts, Alissa M., Durgerian, Sally, Hantke, Nathan C., Lancaster, Melissa A., Nielson, Kristy A., Rao, Stephen M., Seidenberg, Michael, Smith, J. Carson, Verber, Matthew D., Woodard, John L.   +10 more
core   +2 more sources

Comparison of internal cognitive training versus external cognitive training on mild cognitive impairment among elderly population

Bulletin of Faculty of Physical Therapy, 2022
Background Mild cognitive impairment (MCI) is a common condition in the elderly population. It is characterized by confusion, disorientation, memory complaints, as well as restricted attention, learning, and language abilities.
Asha Dagar, Saurabh Kumar, Raghuveer Raghumahanti, Anushree Rai   +3 more
doaj   +1 more source