Results 121 to 130 of about 200 (179)

Maternal and Early Developmental Effects of Perinatal Exposure to Therapeutically Relevant Doses of Common Nonsteroidal Anti‐Inflammatory Drugs in Rats

Birth Defects Research, Volume 118, Issue 8, August 2026.
ABSTRACT Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used during pregnancy, yet information on their developmental safety during sensitive perinatal windows remains limited. This study evaluated the maternal and early developmental effects of paracetamol/acetaminophen, aspirin, and nimesulide administered at therapeutically ...
Sara Tawany Caetano dos Santos, Reggina Lorena Mellado Castro, Luara Magalhães, Giovanna Ferrari Rosalem, Julia Vitoria Francisco de Aquino, Otávio Galassi Vitale, Livia Trippe Nagaoka, Julia Stein, Beatriz de Matos Manoel, Bárbara Campos Jorge, Arielle Cristina Arena   +10 more
wiley   +1 more source

Study on the Role of FGF9/ERK/MMP9 Pathway in Age‐Related Cataract and in (‐)‐Epigallocatechin‐3‐gallate Protecting Lens Epithelial Cells From Apoptosis

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Age‐related cataract (ARC) is the most prevalent form of cataract. Oxidative stress‐induced apoptosis of lens epithelial cells (LECs) is a major pathogenic factor, but its underlying molecular mechanisms remain incompletely understood. This study investigated the roles of FGF9, ERK, and MMP9 in ARC and examined whether the FGF9/ERK/MMP9 ...
Jiale Yu, Yifan Wu, Jianan Wu, Cuige Shi, Xiaofeng Chen, Ying Wei, Lina Guan, Jialing He, Yue Zhang, Zihan Xiang, Dongmei Su, Shanshan Hu, Xu Ma   +12 more
wiley   +1 more source

ADAMTS4 mediates LPS‐induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
• ADAMTS4 is induced primarily in cardiac fibroblasts during sepsis. • ADAMTS4 cleaves TSP1 at the 236–246 aa functional region. • TSP1 cleavage activates TGF‐β/Smad and NF‐κB signalling in fibroblasts. • Targeting ADAMTS4 reduces fibroblast activation and cardiac fibrosis.
Zhe‐Wei Zhang, Shi‐Yan Wan, Wen Li, Xiao Lu, Rong Chen, Xin Xing, Wei Lai, Shu‐Yang Sheng, M. M. Mosebetsi, Qing‐Tao Meng, Zi‐Long Lu, Di Fan, Wan‐Li Jiang   +12 more
wiley   +1 more source

Postbiotics in Food Systems: Components, Production Methods, Food Applications, Functional Properties, and Technological Challenges

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
This review provides a comprehensive, engineering‐oriented synthesis of postbiotics as next‐generation functional food ingredients. It first outlines the principal production routes for postbiotic generation, encompassing thermal technologies, non‐thermal technologies, and extraction/purification methods, and subsequently examines the analytical and ...
Tansu Taspinar, Nuray Güzeler
wiley   +1 more source

Pretreatment‐Driven Modulation of Green Mango Drying: Kinetics, Energy Consumption, Techno‐Functionality, and Environmental Sustainability

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Hot‐air drying of green mango slices was evaluated following three pretreatments: citric acid (CA), hot water blanching (HWB), and steam blanching (SB). The effects of pretreatment and drying temperature were assessed through drying kinetics, thin‐layer modeling, thermodynamic properties, energy performance, product quality, and environmental impacts ...
S. K. Fahim Tahmid Boni, S. M. Johir Rayhan, Pabitra Chandra Das, Mohammad Nurur Rahman, Farzana Haque Reeti, Md Zahir Mahmud, Md. Sajjad Hossain   +6 more
wiley   +1 more source

Successful propranolol therapy for infantile hepatic hemangioma with cardiac failure

JPGN Reports, Volume 7, Issue 3, Page 387-390, August 2026.
Abstract Infantile hepatic hemangioma (IHH) can cause severe complications such as high‐output cardiac failure and growth faltering, requiring prompt diagnosis and intervention. In the absence of standardized treatment guidelines, propranolol has emerged as an effective and well‐tolerated therapy.
Fadhel Al Ateeqi, Ala K. Shaikhkhalil, Haitham Talo, Naeem Jagirdar, Mahdia AL‐Haidar   +4 more
wiley   +1 more source

Elevated Expression of Selenoprotein Synthesis Enzyme SEPHS2 Driven by ATF4 Promotes the Resistance to Ferroptosis in Prostate Cancer

MedComm, Volume 7, Issue 8, August 2026.
Under the treatment of ferroptosis inducers, the expression of SEPHS2 is upregulated, driven by ATF4, to increase the biosynthesis of selenoproteins (e.g., GPX4) to promote resistance to ferroptosis. ABSTRACT While it has been reported that antioxidant selenoproteins are crucial for anti‐ferroptosis in tumors, it remains unclear whether and how ...
Shijia Bao, Xinxing Du, Zhenkeke Tao, Huixiang Xiao, Jia Zhang, Zhenzhen Wen, Wei‐Qiang Gao, Baijun Dong, Yu‐Xiang Fang, Jianjun Sha   +9 more
wiley   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, Volume 40, Issue 8, Page 4792-4801, August 2026.
ABSTRACT The preclinical evidence for the safety of ashwagandha ( Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports. Most studies and reviews conclude
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Analytical Ultracentrifugation in Aotearoa: A Brief History of the Technique and its Place Among Other Tools Used to Investigate Biomolecular Interactions

Journal of the Royal Society of New Zealand, Volume 56, Issue 4, August 2026.
Analytical ultracentrifugation (AUC) is a powerful and versatile tool for studying biomolecular interactions. The purpose of this commentary is to provide foundational knowledge of the technique and its uses through the presentation of two case studies in which AUC provides key data to answer research questions.
Liam S. Turk, Zachary D. Tillett, Rebecca E. McKenzie, Sarah L. Draper, Gavin F. Painter, Renwick C. J. Dobson   +5 more
wiley   +1 more source

The ELAVL1‐PLAUR‐suPAR Axis Exacerbates Diabetic Nephropathy by Promoting Podocyte Injury and Inflammation

Journal of Diabetes, Volume 18, Issue 8, August 2026.
This study identifies a novel pathogenic pathway in DN wherein hyperglycemia‐induced ELAVL1 upregulates PLAUR expression and promotes suPAR release from podocytes, leading to renal inflammation and injury. ABSTRACT Background Diabetic nephropathy (DN) is a leading cause of end‐stage renal disease.
DanDan Xu, Liang Xu, LinLin Li
wiley   +1 more source