Results 221 to 230 of about 2,196,088 (287)

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

The defining characteristics of pasture-based systems in temperate regions. [PDF]

JDS Commun
Horan B, Stirling S, Bryant R, Delaby L.
europepmc   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Multi-objective optimization of national dietary guidelines: balancing nutrition, environment, and economy. [PDF]

Front Nutr
Hu Y, Zhao F, Zhang M, Wang T, Li H, Fu T, Gao T, Su C.   +7 more
europepmc   +1 more source

Evaluating sugar-sweetened beverage tax effects: online price and sales data from grocers in Canada. [PDF]

Health Promot Int
Prowse R, Zaltz D, Crichton K, Dooley K, Hammond D, Yi Y, Paquette MC, Wang PP, Raine K, Harding SV.   +9 more
europepmc   +1 more source

Impacts of large-scale food fortification on the cost of nutrient-adequate diets: a modelling study in 89 countries. [PDF]

BMJ Public Health
Costlow L, Bai Y, Adams KP, Beal T, Dewey KG, Free CM, Friesen VM, Mbuya MNN, Nordhagen S, Vasta FC, Masters WA.   +10 more
europepmc   +1 more source

Comparison of volatile aroma compounds and consumer perception between domestic and imported milk in Korea. [PDF]

Food Sci Anim Resour
Park MK, Park S, Yoon G, Lee CL, Kwak HS.   +4 more
europepmc   +1 more source

A Survey of Traditional Animal-Origin Foods and Preliminary Assessment of Market Characteristics at the Hornbill Festival in Nagaland, India. [PDF]

Foods
Vikram R, Jawla J, Somagond YM, Devi LS, Narendra VN, Pal S, Choudhary J, Khate K, Barman K, Ponraj P, Girish PS.   +10 more
europepmc   +1 more source

A higher-output grass-based spring-calving dairy production system in Ireland-Factors influencing performance variability over a 9-year period. [PDF]

JDS Commun
Pierce KM, McKay ZC, McCarthy KM, Fahey AG, Wallace M, Lynch MB, Walsh NA, Ryan N, Dooley N, Mulligan FJ.   +9 more
europepmc   +1 more source