Results 201 to 210 of about 27,275 (257)

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Modulation of the rumen microbiome and metabolism in dairy cows by altering the concentrate feeding pattern and the inclusion of <i>Saccharomyces cerevisiae</i> yeast. [PDF]

Front Microbiomes
Snelling TJ, Johnson CA, Warren HE, Taylor-Pickard J, Huntington JA, Sinclair LA.   +5 more
europepmc   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

<i>Eucheuma cottonii</i>-enriched legume-based green concentrate improves rumen protein utilization, methane mitigation, and lactation performance in Holstein Friesian dairy cows. [PDF]

Vet World
Utamy RF, Ako A, Ramadan Z, Mustabi J, Rahman MM, Umpuch K.   +5 more
europepmc   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Partial Substitution of Soybean Meal with a Yeast-Fermented Vinasse Protein Source: Effects on Milk Yield, Composition, and Serum Biochemistry in Crossbred Dairy Cows. [PDF]

Metabolites
Akdag A.
europepmc   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Dietary Mannan Oligosaccharide Supplementation During Gestation Alters Milk Composition in Jennies and Improves Growth Performance, Lipid Metabolism, and Gut Microbiota in Dezhou Donkey Foals. [PDF]

Microorganisms
Li H, Luo J, Wen Z, Yin Y, Huang S, Shi D.   +5 more
europepmc   +1 more source

Sodium Bicarbonate Can Increase Milk Fat Concentration in Lactating Ewes Fed Ryegrass Herbage Rich in Water-Soluble Carbohydrates. [PDF]

Animals (Basel)
Porcu MA, Ledda A, Carta S, Francesconi AHD, Cannas A.   +4 more
europepmc   +1 more source

Enteric Methane Emission and Milk Component Profiles of Holstein and Jersey Cows: A Respiration Chamber Study. [PDF]

Animals (Basel)
Park J, Eom JS, Kim DH, Park SM, Han SB, Kim Y, Dang CG, Lim DH.   +7 more
europepmc   +1 more source