Results 51 to 60 of about 27,275 (257)

Impact of crude protein content in silage and concentrate on protein and fatty acid profiles in bovine milk

Czech Journal of Animal Science, 2013
Two concentrates, one protein-rich and one based on cereals, were combined with two silages with a crude protein content of 17 and 13% of dry matter (DM), respectively to give four different diets for dairy cows.
M. Johansson, O. Placha, J. Pickova, A. Andrén, G. Zamaratskaia, E. Spörndly, M. Åkerstedt   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Long-term effects of subacute ruminal acidosis (SARA) on milk quality and hepatic gene expression in lactating goats fed a high-concentrate diet. [PDF]

PLoS ONE, 2013
PURPOSE: The mechanism underlying the decline in milk quality during periods of feeding high-concentrate diets to dairy ruminants is not well documented.
Haibo Dong, Shaoqing Wang, Yuanyuan Jia, Yingdong Ni, Yuanshu Zhang, Su Zhuang, Xiangzhen Shen, Ruqian Zhao   +7 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Physicochemical characteristics of ewe’s milk following partial substitution of concentrate with Date by–products and Saccharomyces cerevisiae

Revista Científica
Sustainable feeding strategies are needed to improve the quantity and quality of sheep milk. This study evaluated the impact of partially substituting conventional concentrate with  date by– products, with or without the addition of Saccharomyces ...
Tarek Boussaada, Salha Amira Benatallah , Boukaous Leyla, Kaouthar Lakhdari, Abdelhamid Djekoun, Nedjoua Lakhdara   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Associations between milk protein concentration, milk yield, and reproductive performance in dairy cows [PDF]

Journal of Dairy Science, 2016
Milk protein concentration in dairy cows has been positively associated with a range of measures of reproductive performance. It was possible that these associations were due to confounding by milk volume. A retrospective single cohort study was conducted using data collected from 74 dairy herds with seasonal or split calving patterns.
J M, Morton, M J, Auldist, M L, Douglas, K L, Macmillan   +3 more
openaire   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Effect of pre-partum and post-partum concentrate supplementation on milk yield and quality, calf birth weight and post-partum heat period of Holstein-Friesian crossbred cows

Fundamental and Applied Agriculture, 2018
Twelve Holstein-Friesian crossbred cows were selected for an on-farm study in a completely randomized design to exemplify the effects of pre- and post-partum concentrate supplementation on calf birth weight, milk production and composition; and post ...
Naima Zaman Prima, Md. Abdus Samad Khan, Md. Rezwanul Habib, Mohammad Ashiqul Islam   +3 more
doaj   +1 more source

Prediction of Milk Protein Concentration from Elements of the Metabolizable Protein System

Journal of Dairy Science, 1998
Elements of the metabolizable protein system in the United Kingdom were examined for their suitability as potential predictors of milk protein concentration. Models were based on data from 163 cows offered five forage mixtures for ad libitum intake plus concentrates at 3, 6, or 9 kg/d of dry matter. The models were then tested on a separate data set of
Smoler, E., Rook, A. J., Sutton, J. D., Beever, D. E.   +3 more
openaire   +2 more sources