Results 71 to 80 of about 27,275 (257)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Measurement of Protein Stability in Sterile Concentrated Milk

Journal of Dairy Science, 1964
Abstract Gold sols were used to determine stability of protein to Ca ++ by adding 0.5ml of 0.01 to 0.02% protein solution to 10ml of gold sol, followed by 1.0ml of m CaCl 2 . Optical densities were determined at 535m μ after 1 hr. Reference protein solutions served as standards.
S. Nakai, H.K. Wilson, E.O. Herreid
openaire   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Texture profile in processed cheese: influence of the use of milk protein concentrates and whey protein concentrates

Revista do Instituto de Latícinios Cândido Tostes, 2014
The techno-functional properties of proteins related with the molecular characteristics are facilitated by partial unfolding of structures. From these interactions, the medium pH is presented as a major interferer in intensity and type of reaction that ...
Alisson Borges Souza, Luiz Carlos Gonçalves Costa Júnior, Ítalo Tuler Perrone, Rodrigo Stephani, Débora de Freitas Almeida   +4 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Amino Acid Composition of Dried Bovine Dairy Powders from a Range of Product Streams

Foods
The amino acid (AA) content of multiple samples of various dairy powders was determined, providing a comprehensive evaluation of the differences in AA profiles attributable to distinct manufacturing processes. Products examined included whole milk powder
Simon R. Gilmour, Stephen E. Holroyd, Maher D. Fuad, Dave Elgar, Aaron C. Fanning   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Performance of lactating dairy cows fed sunflower or corn silages and concentrate based on citrus pulp or ground corn

Revista Brasileira de Zootecnia
This study aimed to evaluate the effect of diets containing sunflower or corn silages and concentrate based on citrus pulp or ground corn on intake, apparent digestibility, feeding behavior, microbial protein production, and production, composition, and ...
Leonardo Andrade Leite, Ronaldo Braga Reis, Patrícia Guimarães Pimentel, Helton Mattana Saturnino, Sandra Gesteira Coelho, Guilherme Rocha Moreira   +5 more
doaj   +1 more source

Tampilan kualitas susu sapi perah akibat imbangan konsentrat dan hijauan yang berbeda

Jurnal Ilmu-Ilmu Peternakan, 2015
The aim of this study was to assess the optimal balance ration of concentrate and forage to improve dairy milk production. The research was conducted at regional operational unit Mulyorejo, Barukan village, Tengaran Sub District, Semarang Regency, and ...
Danes Suhendra, G. T. Anggiati, S. Sarah, A. F. Nasrullah, A. Thimoty, D. W. C. Utama   +5 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source