Results 91 to 100 of about 179,821 (344)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Genome-wide associations for milk production and somatic cell score in Holstein-Friesian cattle in Ireland

, 2012
peer-reviewedBackground: Contemporary dairy breeding goals have broadened to include, along with milk production traits, a number of non-production-related traits in an effort to improve the overall functionality of the dairy cow.
David J Lynn, Fahey, Alan G., Lynn David J, Francis J Kearney, Daniel G Bradley, Bradley, Daniel G, Kearney Francis J, Meredith, Brian K, Finlay Emma K, Bradley Daniel G, Lynn, David J, Kearney, Francis, Finlay, Emma K., Fahey Alan G, Berry Donagh P, Donagh P Berry, Brian K Meredith, Alan G Fahey, Emma K Finlay, Berry, Donagh, Meredith Brian K   +20 more
core   +1 more source

Effect of pre-partum and post-partum concentrate supplementation on milk yield and quality, calf birth weight and post-partum heat period of Holstein-Friesian crossbred cows

Fundamental and Applied Agriculture, 2018
Twelve Holstein-Friesian crossbred cows were selected for an on-farm study in a completely randomized design to exemplify the effects of pre- and post-partum concentrate supplementation on calf birth weight, milk production and composition; and post ...
Naima Zaman Prima, Md. Abdus Samad Khan, Md. Rezwanul Habib, Mohammad Ashiqul Islam   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Physicochemical characteristics of ewe’s milk following partial substitution of concentrate with Date by–products and Saccharomyces cerevisiae

Revista Científica
Sustainable feeding strategies are needed to improve the quantity and quality of sheep milk. This study evaluated the impact of partially substituting conventional concentrate with  date by– products, with or without the addition of Saccharomyces ...
Tarek Boussaada, Salha Amira Benatallah , Boukaous Leyla, Kaouthar Lakhdari, Abdelhamid Djekoun, Nedjoua Lakhdara   +5 more
doaj   +1 more source

Justification of unconventional protein-containing raw materials for the construction of milk chocolate formulas with increased biological value

Vestnik MGTU, 2020
Milk chocolate is particularly popular with different age groups. It is characterized by low protein content with a large amount of fats and carbohydrates determining the food imbalance of the product.
Linovskaya N. V., Mazukabzova E. V., Rudenko O. S. , Savenkova T. V.   +3 more
doaj   +1 more source

Prediction of Milk Protein Concentration from Elements of the Metabolizable Protein System

Journal of Dairy Science, 1998
Elements of the metabolizable protein system in the United Kingdom were examined for their suitability as potential predictors of milk protein concentration. Models were based on data from 163 cows offered five forage mixtures for ad libitum intake plus concentrates at 3, 6, or 9 kg/d of dry matter. The models were then tested on a separate data set of
Smoler, E., Rook, A. J., Sutton, J. D., Beever, D. E.   +3 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Changes in milk performance and hepatic metabolism in mid-lactating dairy goats after being fed a high concentrate diet for 10 weeks

Animal, 2017
Feeding a high concentrate (HC) diet is a widely used strategy for supporting high milk yields, yet it may cause certain metabolic disorders. This study aimed to investigate the changes in milk production and hepatic metabolism in goats fed different ...
H.B. Dong, L.L. Sun, R.H. Cong, S.Y. Tao, Y.Q. DuanMu, J. Tian, Y.D. Ni, R.Q. Zhao   +7 more
doaj   +1 more source