ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma+18 more
wiley +1 more source
Helminth co-infections have no additive detrimental impact on milk yield and milk quality compared to mono-infections in German dairy cows. [PDF]
May K, Hecker AS, König S, Strube C.
europepmc +1 more source
Influence of Amount and Degree of Saturation of Dietary Fat on Yield and Quality of Milk
G.K. Macleod, A.S. Wood
openalex +1 more source
piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization
PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, have been implicated in the development of various diseases. This study explores the tumor‐suppressive mechanism of a downregulated piRNA (designated piR‐RCC) in renal cell carcinoma (RCC), and provides a delivery strategy targeting RCC tumor by constructing a cell membrane ...
Ruyue Wang+16 more
wiley +1 more source
Advancements in Dairy Research: Exploring Nutritional Strategies, Enhancing Raw Milk Quality and Innovations-Unveiling the Topic "New Insights into Milk 2.0". [PDF]
Priyashantha H, Vidanarachchi JK.
europepmc +1 more source
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao+6 more
wiley +1 more source
Effects of Different Technological Forms of the Perilla frutescens in the Diet on Ruminal Fermentation, Milk and Plasma Fatty Acid Composition, Ruminal Biohydrogenation and Milk Quality in Dairy Goats. [PDF]
Beyzi SB+4 more
europepmc +1 more source
Comparative Study Of The Quality Of Rasomalai Manufactured From Cow And Buffalo Milk
M Sayedatunnesha+4 more
openalex +2 more sources
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi+20 more
wiley +1 more source