Results 131 to 140 of about 1,984 (304)
Erratum: The escape velocity curve of the Milky Way in modified Newtonian dynamics [PDF]
, 2018 Indranil Banik, Hongsheng Zhao
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Advanced Science, EarlyView.YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang +8 more
wiley +1 more source
Tracing Red Giant Members of the Globular Cluster Palomar 5 with APOGEE and Gaia
The Astrophysical JournalThe globular cluster Palomar 5 (Pal 5) is in the process of being tidally shredded as it orbits the Milky Way. Its core is currently at a heliocentric distance of ∼21 kpc, near apogalacticon (∼18 kpc), and it reaches ∼5–7 kpc at perigalacticon.
Allyson A. Sheffield +7 more
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Impact of cosmological satellite galaxies on the dynamics of the Milky Way disc
, 2016 Reza Moetazedian
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Advanced Science, EarlyView.Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian +26 more
wiley +1 more source
Flipping of the Tidal Tails of the Ophiuchus Stream due to the Decelerating Galactic Bar
The Astrophysical JournalThe Ophiuchus stellar stream presents a puzzle due to its complicated morphology, with a substructure perpendicular to the main track (spur), a broadened tail (fanning), and a shorter than expected angular extent given its old stellar population and ...
Yong Yang +18 more
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NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction
Advanced Science, EarlyView.NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu +15 more
wiley +1 more source
A census of the expected properties of classical Milky Way dwarfs in Milgromian dynamics [PDF]
, 2014 Fabian Lüghausen +2 more
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The dynamic Milky Way in the Gaia era
The Milky Way is a relatively typical galaxy, and we are in the middle of it. That allows astronomers to observe an enormous amount of individual stars and their properties. With the success of the Gaia mission, the amount of catalogued stars is reaching into the billions.
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Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source