Results 31 to 40 of about 540,184 (283)

Locally Cold Flows from Large-Scale Structure [PDF]

, 2011
We show that the "cold" Hubble flow observed for galaxies around the Milky Way does not represent a problem in cosmology but is due to the particular geometry and dynamics of our local wall. The behavior of the perturbed Hubble flow around the Milky Way is the result of two main factors: at small scales (R < 1 Mpc) the inflow is dominated by the ...
arxiv   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Candidate Members of the VMP/EMP Disk System of the Galaxy from the SkyMapper and SAGES Surveys

The Astrophysical Journal Supplement Series
Photometric stellar surveys now cover a large fraction of the sky, probe to fainter magnitudes than large-scale spectroscopic surveys, and are relatively free from the target selection biases often associated with such studies.
Jihye Hong, Timothy C. Beers, Young Sun Lee, Yang Huang, Yutaka Hirai, Jonathan Cabrera Garcia, Derek Shank, Shuai Xu, Haibo Yuan, Mohammad K. Mardini, Thomas Catapano, Gang Zhao, Zhou Fan, Jie Zheng, Wei Wang, Kefeng Tan, Jingkun Zhao, Chun Li   +17 more
doaj   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Milky Way Gas Dynamics [PDF]

, 2006
The Milky Way is made up of a central bar, a disk with embedded spiral arms, and a dark matter halo. Observational and theoretical constraints for the characteristic parameters of these components will be presented, with emphasis on the constraints from the dynamics of the Milky Way gas.
arxiv   +1 more source

Revisiting mass estimates of the Milky Way [PDF]

arXiv, 2023
We use the rotation curve from Gaia data release (DR) 3 to estimate the mass of the Milky Way. We consider an Einasto density profile to model the dark matter component. We extrapolate and obtain a dynamical mass $M=2.75^{+3.11}_{-0.48}\times 10^{11} M_\odot$ at $112$ kpc.
arxiv  

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Epitope Mapping of Anti‐Neurofascin 155 Antibody in a Large Cohort of Autoimmune Nodopathy Patients

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune nodopathy (AN), a newly recognized disease entity, is an immune‐mediated polyneuropathy involving autoantibodies against cell adhesion molecules located in nodes of Ranvier and paranodal regions, such as neurofascin 186 (NF186) and neurofascin 155 (NF155). The present study aimed to identify the epitopes for autoantibodies
Amina A. Abdelhadi, Hidenori Ogata, Xu Zhang, Takumi Tashiro, Ryo Yamasaki, Jun‐ichi Kira, Noriko Isobe   +6 more
wiley   +1 more source

An Inward-moving and Asymmetric Velocity Wave Detected in LAMOST-Gaia

The Astrophysical Journal Letters
The phase space, as coded by kinematic parameters and chemical abundances, is crucial for understanding the formation of the Galactic disk. Using red giant stars from the Galactic thin disk with [Fe/H] > − 0.8 and low- α ratios identified in LAMOST-Gaia,
Yuqin Chen, Gang Zhao, Wenbo Wu, Zixi Guo, Haopeng Zhang, Zhuohan Li   +5 more
doaj   +1 more source