Results 51 to 60 of about 45,061 (325)

Testing two alternatives theories to dark matter with the Milky Way dynamics

, 2015
Two alternative theories to dark matter are investigated by testing their ability to describe consistently the dynamics of the Milky Way. The first one refers to a modified gravity theory having a running gravitational constant and the second assumes ...
de Oliveira, P. L. C., Pacheco, J. A. de Freitas, Reinisch, G.   +2 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Candidate Members of the VMP/EMP Disk System of the Galaxy from the SkyMapper and SAGES Surveys

The Astrophysical Journal Supplement Series
Photometric stellar surveys now cover a large fraction of the sky, probe to fainter magnitudes than large-scale spectroscopic surveys, and are relatively free from the target selection biases often associated with such studies.
Jihye Hong, Timothy C. Beers, Young Sun Lee, Yang Huang, Yutaka Hirai, Jonathan Cabrera Garcia, Derek Shank, Shuai Xu, Haibo Yuan, Mohammad K. Mardini, Thomas Catapano, Gang Zhao, Zhou Fan, Jie Zheng, Wei Wang, Kefeng Tan, Jingkun Zhao, Chun Li   +17 more
doaj   +1 more source

Interactions of the Galactic bar and spiral arm in NGC 3627 [PDF]

, 2016
Aims: To gain insight into the expected gas dynamics at the interface of the Galactic bar and spiral arms in our own Milky Way galaxy, we examine as an extragalactic counterpart the evidence of multiple distinct velocity components in the cold dense ...
Beuther, H, Leroy, A, Paladino, R, Schinnerer, E, van der Wel, Sharon Meidt   +4 more
core   +3 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Additional Evidence for the Existence of a Primordial Disk System

The Astrophysical Journal
The origin of very metal-poor (VMP; [Fe/H] ≤ −2.0) stars on planar orbits has been the subject of great attention since their first discovery. However, prior to the release of the Gaia BP/RP (XP) spectra and large photometric samples such as SkyMapper ...
Shuai Xu, Haibo Yuan, Bowen Huang, Timothy C. Beers, Yang Huang, Maosheng Xiang, Kai Xiao, Jihye Hong, Young Sun Lee, Wuming Yang   +9 more
doaj   +1 more source

Stream Fanning and Bifurcations: Observable Signatures of Resonances in Stellar Stream Morphology

The Astrophysical Journal, 2023
Recent observations have revealed a trove of unexpected morphological features in many of the Milky Way’s stellar streams. Explanations for such features include time-dependent deformations of the Galactic gravitational potential, local disruptions ...
Tomer D. Yavetz, Kathryn V. Johnston, Sarah Pearson, Adrian M. Price-Whelan, Chris Hamilton   +4 more
doaj   +1 more source

The Milky Way's nuclear star cluster and massive black hole

, 2014
Because of its nearness to Earth, the centre of the Milky Way is the only galaxy nucleus in which we can study the characteristics, distribution, kinematics, and dynamics of the stars on milli-parsec scales.
Schödel, Rainer
core   +1 more source

GAS DYNAMICS IN THE MILKY WAY: A LOW PATTERN SPEED MODEL [PDF]

The Astrophysical Journal, 2016
ABSTRACT We present gas flow models for the Milky Way based on high-resolution grid-based hydrodynamical simulations. The basic galactic potential we use is from an N-body model constrained by the density of red clump giants in the Galactic bulge.
Zhi Li, Ortwin Gerhard, Juntai Shen, Matthieu Portail, Christopher Wegg   +4 more
openaire   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source