Results 91 to 100 of about 155,710 (341)

Milky Way Star Clusters and Gaia: A Review of the Ongoing Revolution

Universe, 2022
The unprecedented quality of the astrometric measurements obtained with the ESA Gaia spacecraft have initiated a revolution in Milky Way astronomy. Studies of star clusters in particular have been transformed by the precise proper motions and parallaxes ...
T. Cantat-Gaudin
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

The Age-dependent Vertical Actions of Young Stars in the Galaxy

The Astrophysical Journal
Stars in the Galactic disk are born on cold, nearly circular orbits with small vertical excursions. After their birth, their orbits evolve, driven by small- or large-scale perturbations in the Galactic disk’s gravitational potential.
D. N. Garzon, Neige Frankel, Eleonora Zari, Maosheng Xiang, Hans-Walter Rix   +4 more
doaj   +1 more source

The evolution of the Milky Way: New insights from open clusters [PDF]

, 2016
We have collected high-dispersion echelle spectra of red giant members in the twelve open clusters (OCs) and derived stellar parameters and chemical abundances for 26 species by either line equivalent widths or synthetic spectrum analyses. We confirm the
A. B. Reddy, D. Lambert, Sunetra Giridhar W.J. McDonald Observatory, D. O. Astronomy, T. Astrophysics   +4 more
semanticscholar   +1 more source

The evolution of carbon and oxygen in the bulge and disk of the Milky Way [PDF]

Astronomy & Astrophysics, 2009
The evolution of C and O abundances in the Milky Way can impose strong constraints on stellar nucleosynthesis and help understanding the formation and evolution of our Galaxy. The aim is to review the measured C and O abundances in the disk and bulge of the Galaxy and compare them with model predictions.
Andrew McWilliam, Gabriele Cescutti, Cristina Chiappini, Cristina Chiappini, Francesca Matteucci, Francesca Matteucci   +5 more
openaire   +5 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

An Inward-moving and Asymmetric Velocity Wave Detected in LAMOST-Gaia

The Astrophysical Journal Letters
The phase space, as coded by kinematic parameters and chemical abundances, is crucial for understanding the formation of the Galactic disk. Using red giant stars from the Galactic thin disk with [Fe/H] > − 0.8 and low- α ratios identified in LAMOST-Gaia,
Yuqin Chen, Gang Zhao, Wenbo Wu, Zixi Guo, Haopeng Zhang, Zhuohan Li   +5 more
doaj   +1 more source

The origin and evolution of the odd-Z iron-peak elements Sc, V, Mn, and Co in the Milky Way stellar disk ?,?? [PDF]

, 2015
AIMS: The aim of this study is to investigate the origin and evolution of Sc, V, Mn, and Co for a homogeneous and statistically significant sample of stars probing the different populations of the Milky Way, in particular the thin and thick disks ...
C. Battistini, T. B. L. Observatory, D. O. Astronomy, T. Physics, Lund, Sweden.   +5 more
semanticscholar   +1 more source

The Chemical Evolution of the Milky Way Galaxy

, 2021
The elemental abundance gradients of elements up to Zn are predicted using the N body Monte Carlo technique by developing homogenous and heterogeneous Galactic Chemical Evolution (GCE) simulations. In the case of homogeneous GCE models, the galaxy is radially divided into eight annular rings of 2 kpc width each at a distance of 2-18 kpc from the center
openaire   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source