Results 101 to 110 of about 77,216 (325)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The Three-Phase Evolution of the Milky Way [PDF]

, 2023
Vedant Chandra, Vadim A. Semenov, Hans‐Walter Rix, Charlie Conroy, Ana Bonaca, Rohan P. Naidu, R. Andrae, Jiadong Li, Lars Hernquist   +8 more
openalex   +1 more source

Gas Loss by Ram Pressure Stripping and Internal Feedback From Low Mass Milky Way Satellites

, 2016
The evolution of dwarf satellites of the Milky Way is affected by the combination of ram pressure and tidal stripping, and internal feedback from massive stars.
Emerick, Andrew, Gatto, Andrea, Grcevich, Jana, Mac Low, Mordecai-Mark   +3 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Effects of radial flows on the chemical evolution of the Milky Way disk

, 2011
The majority of chemical evolution models assume that the Galactic disk forms by means of infall of gas and divide the disk into several independent rings without exchange of matter between them.
Andrievsky, Andrievsky, Asplund, Cescutti, Cescutti, Chiappini, Chiappini, Chiappini, Colavitti, Costa, Dame, Deharveng, E. Spitoni, Esteban, F. Matteucci, François, Greggio, Götz, Iwamoto, Kennicutt, Kennicutt, Lacey, Maeder, Mannucci, Marcon-Uchida, Martin, Matteucci, Matteucci, Mayor, Pagel, Portinari, Portinari, Rana, Rudolph, Scalo, Schaye, Schmidt, Schönrich, Sommer-Larsen, Spitoni, Talbot, Thon, Timmes, van den Hoek, Woosley   +44 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

The Rapid Formation of the Metal-poor Milky Way

The Astrophysical Journal
Our understanding of the assembly timeline of the Milky Way has been transforming along with the dramatic increase in astrometric and spectroscopic data available over the past several years.
Turner Woody, Charlie Conroy, Phillip Cargile, Ana Bonaca, Vedant Chandra, Jiwon Jesse Han, Benjamin D. Johnson, Rohan P. Naidu, Yuan-Sen Ting   +8 more
doaj   +1 more source

VISTA Milky Way public survey [PDF]

, 2009
We propose a public IR variability survey, named \Vista Variables in the Vía Láctea" (V V V ), of the Milky Way bulge and an adjacent section of the mid-plane where star formation activity is high. This would take 1920 hours, covering ~ 109 point sources
Adamson, A., Ahumada, A. V., Bandyopadhyay, R., Barbuy, B., Barbá, R. H., Barlow, M., Bedin, L., Bica, E., Borissova, J., Bronfman, L., Carraro, G., Casassus, S., CASU (VDFS) team, The, Catelan, M., Clariá, J. J., Cropper, M., de Grijs, R., Drew, J., Eisloeffel, J., Emerson, J., Fabregat, J., Gamen, R., Geisler, D., Gianinni, T., Gieren, W., Goldman, B., Gosling, A., Groot, P., Hambly, N., Hoare, M., Hodgkin, S., Ivanov, V. D., Kerins, E., Kurtev, R., Longmore, A., Lucas, P., Lucey, J., López-Correidora, M., Martin, E., McGowan, K., Mennickent, R. E., Messineo, M., Minniti, D., Mirabel, F., Monaco, L., Morelli, L., Naylor, T., Pietrzynski, G., Pignata, G., Pinfield, D., Rejkuba, M., Ruiz, M. T., Saviane, I., Schroeder, A., Stephens, A., Tapper, C., Thompson, M., Toledo, I., Vanzi, L., Walton, N., WFAU (VDFS) team, The, White, G., Zijlstra, A., Zoccali, M.   +63 more
core   +2 more sources

A trio of new Local Group galaxies with extreme properties

, 2008
We report on the discovery of three new dwarf galaxies in the Local Group. These galaxies are found in new CFHT/MegaPrime g,i imaging of the south-western quadrant of M31, extending our extant survey area to include the majority of the southern ...
Alan W. McConnachie, Annette M. N. Ferguson, Avon Huxor, Geraint F. Lewis, Gregory Fahlman, Harvey Richer, Irwin M., Karachentsev I. D., Lynden-Bell D., Lynden-Bell D., Mike J. Irwin, Nial R. Tanvir, Nicolas F. Martin, Rodrigo A. Ibata, Salaris M., Scott C. Chapman, Sharina M. E.   +16 more
core   +1 more source