Results 121 to 130 of about 77,093 (285)

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

Where is the Supervirial Gas? The Supply from Hot Inflows

The Astrophysical Journal
To understand the presence of the supervirial temperature gas detected in the Milky Way (MW), we present our findings from isolated galaxy simulations of MW-mass systems using GIZMO with the Feedback in Realistic Environments (FIRE-2) stellar feedback ...
Manami Roy, Kung-Yi Su, Smita Mathur, Jonathan Stern   +3 more
doaj   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Differential Accretion of Ionized Low-velocity Gas at the Milky Way’s Disk–Halo Interface

The Astrophysical Journal
We measure line-of-sight velocities of metal absorption and H I emission along 132 QSO sight lines in order to study gas accretion and outflow at the disk–halo interface of the Milky Way.
Hannah V. Bish, Jessica K. Werk, J.E.G. Peek, Enrico Di Teodoro, Yong Zheng, Mary Putman   +5 more
doaj   +1 more source

Chemical evolution and abundance gradients in the Milky Way

, 2001
We extend our model of chemical evolution that successfully account for the main observables in the solar neighborhood (Alibes, Labay & Canal 2001) to the whole Milky Way halo and disk. We assume an inside-out scenario for the assembling of the Galaxy through the infall of external material. Two different compositions of the infalling material have
Alibes, Andreu, Labay, Javier, Canal, Ramon   +2 more
openaire   +2 more sources

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

Advanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu   +10 more
wiley   +1 more source

The Milky Way Radial Metallicity Gradient as an Equilibrium Phenomenon: Why Old Stars Are Metal Rich

The Astrophysical Journal
Metallicities of both gas and stars decline toward large radii in spiral galaxies, a trend known as the radial metallicity gradient. We quantify the evolution of the metallicity gradient in the Milky Way as traced by APOGEE red giants with age estimates ...
James W. Johnson, David H. Weinberg, Guillermo A. Blanc, Ana Bonaca, Gwen C. Rudie, Yuxi (Lucy) Lu, Bronwyn Reichardt Chu, Emily J. Griffith, Tawny Sit, Jennifer A. Johnson, Liam O. Dubay, Miqaela K. Weller, Daniel A. Boyea, Jonathan C. Bird   +13 more
doaj   +1 more source

Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies

Advanced Healthcare Materials, EarlyView.
Four extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Christian Preußer, Dolores J. Salander, Witold Szymanski, Johannes Graumann, Yukai Wang, Kai Zhao, Jörg W. Bartsch, María Gómez‐Serrano, Daniel Bachurski, Silke Reinartz, Elke von Pogge von Strandmann   +10 more
wiley   +1 more source

True Pair-instability Supernova Descendant: Implications for the First Stars’ Mass Distribution

The Astrophysical Journal Letters
The initial mass function (IMF) of the first Population III (Pop III) stars remains a persistent mystery. Their predicted massive nature implies the existence of stars exploding as pair-instability supernovae (PISNe), but no observational evidence had ...
Ioanna Koutsouridou, Stefania Salvadori, Ása Skúladóttir   +2 more
doaj   +1 more source