Results 131 to 140 of about 77,093 (285)

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

A North–South Metallicity Asymmetry in the Outer Galactic Disk—Evidence for the Pericentric Passage of the Sagittarius Dwarf Galaxy

The Astrophysical Journal Letters
We present maps of the mean metallicity distributions on the Galactocentric R – Z plane at different azimuthal angles using red clump stars selected from the LAMOST and APOGEE surveys.
Chun Wang, Yang Huang, Timothy C. Beers, Payel Das, Haibo Yuan, Lizhi Xie, Shi Shao   +6 more
doaj   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

On the Use of Field RR Lyrae as Galactic Probes. VIII. Early Formation of the Galactic Spheroid

The Astrophysical Journal
We introduce a new photometric catalog of RR Lyrae (RRL) variables (∼300,000) mainly based on data available in public datasets. We also present the largest and most homogeneous spectroscopic dataset of RRLs and blue horizontal branch (BHB) stars ever ...
G. Bono, V. F. Braga, M. Fabrizio, M. Tantalo, K. Baeza-Villagra, J. Crestani, V. D’Orazi, M. Dall’Ora, M. Di Criscienzo, G. Fiorentino, M. Gholami, M. Marengo, C. E. Martínez-Vázquez, M. Monelli, J. P. Mullen, A. Nunnari, V. D. Pipwala, Z. Prudil, C. Sneden, G. Altavilla, M. Bergemann, G. Böcek Topcu, R. Buonanno, A. Calamida, E. Carretta, G. Ceci, B. Chaboyer, M. Correnti, R. da Silva, I. Ferraro, F. A. Gómez, G. Iannicola, R.-P. Kudritzki, A. Kunder, S. Kwak, M. Marconi, S. Marinoni, N. Matsunaga, F. Matteucci, A. Monachesi, I. Musella, M. G. Navarro Ovando, G. W. Preston, V. Ripepi, M. Salaris, M. Sánchez-Benavente, E. Spitoni, P. B. Stetson, F. Thévenin, I. B. Thompson, P. B. Tissera, T. Tsujimoto, E. Valenti, A. K. Vivas, A. R. Walker, M. Zoccali, A. Zocchi   +56 more
doaj   +1 more source

An In Situ Embedded B‐MOF Sponge With Shape‐Memory for All‐in‐One Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
A smart shape‐memory sponge dressing (P1A3@B‐MOF) is developed for accelerated diabetic wound healing. It achieves pH‐responsive corelease of Zn2+ and salvianolic acid B, synergistically providing antibacterial action, repolarizing macrophages to the M2 phenotype, and promoting angiogenesis.
Hai Zhou, Chaoyang Huang, Yanqi Chen, Tingzi Zhao, Fengyi Zhu, Gong Jun, Jinrong Zhang, Yingsong Pan, Qiulan Wen, Lei Yang, Huihui Zhang, Lianglong Chen   +11 more
wiley   +1 more source

Biomimetic Copper Nanoparticles Coated with ACE2‐Overexpressing Membranes for Selective SARS‐CoV‐2 Neutralization and Disinfection

Advanced Healthcare Materials, EarlyView.
By fusing ACE2‐overexpressing membrane‐integrated liposome (MIL) with copper nanoparticles, the biomimetic Cu@MIL nanostructures were created that directly hijack the SARS‐CoV‐2 entry pathway. These particles combine potent virus‐targeting precision with intrinsic antiviral activity, achieving rapid neutralization and disinfection.
Pooja Aich, Wei‐Pang Chung, Wen‐Jyun Wang, Hidenobu Takahashi, Ming‐Shun Hsieh, Ying‐Chen Lin, Oh Seok Kwon, Wei‐Peng Li, Wei‐Lun Huang   +8 more
wiley   +1 more source

Thermo‐Fluorescent Bactericidal Quantum Dots Based Smart Multifunctional Textiles via Molecular Surface Engineering and 3D‐Printed Interlocked Architectures

Advanced Healthcare Materials, EarlyView.
A versatile approach is presented for fabricating smart multifunctional textiles by integrating thermo‐fluorescent carbon dot/polymer nanocomposite coatings with 3D‐printed interlocked architectures. The fabrics exhibit temperature‐responsive fluorescence, durable hydrophobicity, strong antibacterial and antioxidant activity, and enhanced UV protection.
Poushali Das, Sayan Ganguly, Parham Khoshbakht Marvi, Misha Muthalali, Fatemeh Parniani, Shiza Hassan, Xiaowu (Shirley) Tang, Seshasai Srinivasan, Amin Reza Rajabzadeh   +8 more
wiley   +1 more source

Zinc‐Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun, XueBo Wei, ZhuoYang Song, JunJun Luo, JingYi Ye, YinNan Zhang, LiFei Zhu, Jie Gao, Hongyu Zhang, Hong Zhu, Xin Wang, Ke Xu   +11 more
wiley   +1 more source

Efficient and Accurate Force Replay in Cosmological-baryonic Simulations

The Astrophysical Journal
We construct time-evolving gravitational potential models for a Milky Way–mass galaxy from the FIRE-2 suite of cosmological-baryonic simulations using basis function expansions.
Arpit Arora, Robyn Sanderson, Christopher Regan, Nicolás Garavito-Camargo, Emily Bregou, Nondh Panithanpaisal, Andrew Wetzel, Emily C. Cunningham, Sarah R. Loebman, Adriana Dropulic, Nora Shipp   +10 more
doaj   +1 more source