Results 51 to 60 of about 77,093 (285)

On the origin of fluorine in the Milky Way

, 2004
The main astrophysical factories of fluorine (19F) are thought to be Type II supernovae, Wolf-Rayet stars, and the asymptotic giant branch (AGB) of intermediate mass stars.
Agostino Renda, Alessandro Chieffi, Alibés, Allende Prieto, Amanda I. Karakas, Bekki, Bertelli, Brad K. Gibson, Cappellaro, Cunha, Dray, Fenner, Forestini, Frost, Frost, Gibson, Holweger, Iglesias, Iwamoto, John C. Lattanzio, Jorissen, Karakas, Karakas, Katia Cunha, Kroupa, Limongi, Lugaro, Meynet, Mowlavi, Myra, Rana, Renzini, Russell, Schaller, Simon Campbell, Smith, Timmes, Vassiliadis, Verne V. Smith, Woosley, Woosley, Woosley, Woosley, Yeshe Fenner   +43 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Constraining the Milky Way Halo Accretion History with Simulated Stellar Halos: Designing the HALO7D-X Survey

The Astrophysical Journal
We present the design for HALO7D-X, a survey of the stellar halo to investigate the accretion history of the Milky Way. The survey will use a combination of Hubble Space Telescope (HST) and Gaia data for sky position and proper motions of faint stars (18 
Miranda Apfel, Kevin McKinnon, Constance M. Rockosi, Puragra Guhathakurta, Kathryn V. Johnston   +4 more
doaj   +1 more source

The formation and early evolution of the Milky Way [PDF]

Symposium - International Astronomical Union, 1985
In broad outline, the traditional picture for the formation of the Milky Way can be summarized as follows. The proto-galaxy consisted of a slowly rotating cloud of metal-free gas that cooled by bremsstrahlung and recombination radiation. As the internal pressure of the gas decreased, it collapsed in stages with smaller dimensions, faster rotation ...
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The Age-dependent Vertical Actions of Young Stars in the Galaxy

The Astrophysical Journal
Stars in the Galactic disk are born on cold, nearly circular orbits with small vertical excursions. After their birth, their orbits evolve, driven by small- or large-scale perturbations in the Galactic disk’s gravitational potential.
D. N. Garzon, Neige Frankel, Eleonora Zari, Maosheng Xiang, Hans-Walter Rix   +4 more
doaj   +1 more source

Detection of a Supervirial Hot Component in the Milky Way Circumgalactic Medium Along Multiple Sight Lines by Using the Stacking Technique

The Astrophysical Journal, 2023
The study of the elusive hot component ( T ≳ 10 ^7 K) of the Milky Way circumgalactic medium (CGM) is a novel topic for understanding Galactic formation and evolution.
Armando Lara-DI, Smita Mathur, Yair Krongold, Sanskriti Das, Anjali Gupta   +4 more
doaj   +1 more source

Dissipationless Formation and Evolution of the Milky Way Nuclear Star Cluster

, 2012
Abridged: In one widely discussed model for the formation of nuclear star clusters (NSCs), massive globular clusters spiral into the center of a galaxy and merge to form the nucleus. It is now known that at least some NSCs coexist with supermassive black
Agarwal, Alessandra Mastrobuono-Battisti, Antonini, Bartko, Bekki, Böker, Carollo, Charbonnel, Côté, David Merritt, Do, Ebisuzaki, Emsellem, Fabio Antonini, Ferrarese, Figer, Figer, Gebhardt, Genzel, Ghez, Gillessen, Gualandris, Hashimoto, Haşegan, Ibata, Jordán, Lauer, Loose, Lotz, Makino, Matthews, Merritt, Merritt, Merritt, Meynet, Milosavljević, Miocchi, Murali, Ostriker, Pesce, Pfuhl, Poon, Portegies Zwart, Roberto Capuzzo-Dolcetta, Rosenberg, Saha, Schaerer, Schaerer, Schaller, Schinnerer, Schinnerer, Schödel, Schödel, Seth, Seth, Sjouwerman, Spitzer, Takahashi, Wehner, Zhao   +59 more
core   +1 more source

Structure and Evolution of the Milky Way [PDF]

, 2011
Proc. of the workshop "Red Giants as Probes of the Structure and Evolution of the Milky Way" (Roma, 15-17 Nov 2010), Astrophysics and Space Science Proceedings, ISBN 978-3-642-18417-8 (eds. A. Miglio, J. Montalban, A. Noels).
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source