Results 61 to 70 of about 76,255 (323)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Age-dependent Vertical Actions of Young Stars in the Galaxy

The Astrophysical Journal
Stars in the Galactic disk are born on cold, nearly circular orbits with small vertical excursions. After their birth, their orbits evolve, driven by small- or large-scale perturbations in the Galactic disk’s gravitational potential.
D. N. Garzon, Neige Frankel, Eleonora Zari, Maosheng Xiang, Hans-Walter Rix   +4 more
doaj   +1 more source

Dissipationless Formation and Evolution of the Milky Way Nuclear Star Cluster

, 2012
Abridged: In one widely discussed model for the formation of nuclear star clusters (NSCs), massive globular clusters spiral into the center of a galaxy and merge to form the nucleus. It is now known that at least some NSCs coexist with supermassive black
Agarwal, Alessandra Mastrobuono-Battisti, Antonini, Bartko, Bekki, Böker, Carollo, Charbonnel, Côté, David Merritt, Do, Ebisuzaki, Emsellem, Fabio Antonini, Ferrarese, Figer, Figer, Gebhardt, Genzel, Ghez, Gillessen, Gualandris, Hashimoto, Haşegan, Ibata, Jordán, Lauer, Loose, Lotz, Makino, Matthews, Merritt, Merritt, Merritt, Meynet, Milosavljević, Miocchi, Murali, Ostriker, Pesce, Pfuhl, Poon, Portegies Zwart, Roberto Capuzzo-Dolcetta, Rosenberg, Saha, Schaerer, Schaerer, Schaller, Schinnerer, Schinnerer, Schödel, Schödel, Seth, Seth, Sjouwerman, Spitzer, Takahashi, Wehner, Zhao   +59 more
core   +1 more source

Evolution of lithium in the Milky Way halo, discs, and bulge [PDF]

Monthly Notices of the Royal Astronomical Society, 2019
Abstract In this work, we study the Galactic evolution of lithium by means of chemical evolution models in the light of the most recent spectroscopic data from Galactic stellar surveys. We consider detailed chemical evolution models for the Milky Way halo, discs, and bulge, and we compare our model predictions with the most recent ...
Grisoni, V., Matteucci, F., Romano, D., Fu, X.   +3 more
openaire   +5 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Estimating the Initial Mass of the Gaia–Enceladus Dwarf Galaxy with a Chemical Evolution Model

The Astrophysical Journal
This work investigates the initial mass and chemical evolution history of the Gaia–Enceladus dwarf galaxy. We combine spectroscopic data from APOGEE with astrometric data from Gaia Data Release 3 to identify Gaia–Enceladus candidate stars via a machine ...
Olcay Plevne, Furkan Akbaba
doaj   +1 more source

The Chemical Evolution of the Milky Way in a cosmological context [PDF]

EAS Publications Series, 2007
A short overview is presented of several topics concerning the evolution of the Milky Way (MW) in a cosmological context. In particular, the metallicity distribution of the MW halo is derived analytically and the halo metallicity and abundance patterns are compared to those of Local Group galaxies.
openaire   +2 more sources

Planetary Nebula Abundances and Morphology: Probing the Chemical Evolution of the Milky Way [PDF]

, 2006
This paper presents a homogeneous study of abundances in a sample of 79 northern galactic planetary nebulae whose morphological classes have been uniformly determined.
Arturo Manchado, Brocklehurst M., Cahn J. H., Clegg R. E. S., Corradi R. L. M., Cuisinier F., Eva Villaver, Katia Cunha, Kingsburgh R. L., Letizia Stanghellini, Maciel W. J., Maciel W. J., Martin Antonio Guerrero, Martins L. P., Schwarz H. E., Stanghellini L.   +15 more
core   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

An Inward-moving and Asymmetric Velocity Wave Detected in LAMOST-Gaia

The Astrophysical Journal Letters
The phase space, as coded by kinematic parameters and chemical abundances, is crucial for understanding the formation of the Galactic disk. Using red giant stars from the Galactic thin disk with [Fe/H] > − 0.8 and low- α ratios identified in LAMOST-Gaia,
Yuqin Chen, Gang Zhao, Wenbo Wu, Zixi Guo, Haopeng Zhang, Zhuohan Li   +5 more
doaj   +1 more source