Results 71 to 80 of about 75,563 (322)

The Chemical Evolution of the Milky Way in a cosmological context [PDF]

EAS Publications Series, 2007
A short overview is presented of several topics concerning the evolution of the Milky Way (MW) in a cosmological context. In particular, the metallicity distribution of the MW halo is derived analytically and the halo metallicity and abundance patterns are compared to those of Local Group galaxies.
openaire   +3 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Estimating the Initial Mass of the Gaia–Enceladus Dwarf Galaxy with a Chemical Evolution Model

The Astrophysical Journal
This work investigates the initial mass and chemical evolution history of the Gaia–Enceladus dwarf galaxy. We combine spectroscopic data from APOGEE with astrometric data from Gaia Data Release 3 to identify Gaia–Enceladus candidate stars via a machine ...
Olcay Plevne, Furkan Akbaba
doaj   +1 more source

Contrasting the chemical evolution of the Milky Way and Andromeda [PDF]

Monthly Notices of the Royal Astronomical Society, 2005
The chemical evolution history of a galaxy hides clues about how it formed and has been changing through time. We have studied the chemical evolution history of the Milky Way (MW) and Andromeda (M31) to find which are common features in the chemical evolution of disc galaxies as well as which are galaxy-dependent.
Renda, Agostino, Kawata, Daisuke, Fenner, Yeshe, Gibson, Brad K.   +3 more
openaire   +4 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

An Inward-moving and Asymmetric Velocity Wave Detected in LAMOST-Gaia

The Astrophysical Journal Letters
The phase space, as coded by kinematic parameters and chemical abundances, is crucial for understanding the formation of the Galactic disk. Using red giant stars from the Galactic thin disk with [Fe/H] > − 0.8 and low- α ratios identified in LAMOST-Gaia,
Yuqin Chen, Gang Zhao, Wenbo Wu, Zixi Guo, Haopeng Zhang, Zhuohan Li   +5 more
doaj   +1 more source

Cosmological pseudobulge formation

, 2012
Bulges can be classified into classical and pseudobulges; the former are considered to be end products of galactic mergers and the latter to form via secular evolution of galactic disks.
Okamoto, Takashi
core   +1 more source

The AMBRE project: Constraining the lithium evolution in the Milky Way [PDF]

Astronomy & Astrophysics, 2016
The chemical evolution of lithium in the Milky Way represents a major problem in modern astrophysics. Indeed, lithium is, on the one hand, easily destroyed in stellar interiors, and, on the other hand, produced at some specific stellar evolutionary stages that are still not well constrained.
Prantzos, N., Masseron, T., De Pascale, M., Worley, C., Recio-Blanco, A., De Laverny, P., Guiglion, G., Mikolaitis, Š., Mikolaitis, S., Prantzos, N., Masseron, T., De Pascale, M., Worley, C., Recio-Blanco, A., De Laverny, P., Guiglion, G., Mikolaitis, S.   +16 more
openaire   +6 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

The star-formation history of the Milky Way Galaxy

, 2009
The star-formation histories of the main stellar components of the Milky Way constrain critical aspects of galaxy formation and evolution. I discuss recent determinations of such histories, together with their interpretation in terms of theories of disk ...
Bensby, Bensby, Bensby, Cignoni, Famaey, François, Maiolino, Nordström, Rocha-Pinto, Rosemary F. G. Wyse, Wyse, Wyse   +11 more
core   +1 more source