Results 81 to 90 of about 76,255 (323)

The star-formation history of the Milky Way Galaxy

, 2009
The star-formation histories of the main stellar components of the Milky Way constrain critical aspects of galaxy formation and evolution. I discuss recent determinations of such histories, together with their interpretation in terms of theories of disk ...
Bensby, Bensby, Bensby, Cignoni, Famaey, François, Maiolino, Nordström, Rocha-Pinto, Rosemary F. G. Wyse, Wyse, Wyse   +11 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

What Is Missing from the Local Stellar Halo?

The Astrophysical Journal
The Milky Way’s stellar halo, which extends to >100 kpc, encodes the evolutionary history of our Galaxy. However, most studies of the halo to date have been limited to within a few kiloparsecs of the Sun.
Katherine Sharpe, Rohan P. Naidu, Charlie Conroy   +2 more
doaj   +1 more source

The chemodynamical evolution of the Milky Way disc -- A new modeling approach

, 2013
Despite the recent advancements in the field of galaxy formation and evolution, fully self-consistent simulations are still unable to make the detailed predictions necessary for the planned and ongoing large spectroscopic and photometry surveys of the ...
Chiappini, Cristina, Martig, Marie, Minchev, Ivan   +2 more
core   +1 more source

THE EVOLUTION OF OXYGEN AND MAGNESIUM IN THE BULGE AND DISK OF THE MILKY WAY [PDF]

The Astronomical Journal, 2008
We show that the Galactic bulge and disk share a similar, strong, decline in [O/Mg] ratio with [Mg/H]. The similarity of the [O/Mg] trend in these two, markedly different, populations suggests a metallicity-dependent modulation of the stellar yields from massive stars, by mass loss from winds, and related to the Wolf-Rayet phenomenon, as proposed by ...
MCWILLIAM A, MATTEUCCI, MARIA FRANCESCA, BALLERO S, RICH R. M, FULBRIGHT J. P, CESCUTTI G.   +5 more
openaire   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The Milky Way’s Rowdy Neighbors: The Effects of the Large Magellanic Cloud and Sagittarius Dwarf on the Milky Way Disk

The Astrophysical Journal
The Milky Way (MW) is a barred spiral galaxy shaped by tidal interactions with its satellites. The Large Magellanic Cloud (LMC) and the Sagittarius dwarf galaxy (Sgr) are the dominant influences at the present day. This paper presents a suite of four 10 ^
Ioana A. Stelea, Jason A. S. Hunt, Kathryn V. Johnston   +2 more
doaj   +1 more source

Contrasting copper evolution in ω Centauri and the Milky Way [PDF]

Monthly Notices of the Royal Astronomical Society: Letters, 2007
Abstract Despite the many studies on stellar nucleosynthesis published so far, the scenario for the production of copper in stars remains elusive. In particular, it is still debated whether copper originates mostly in massive stars or in Type Ia supernovae.
Romano, Donatella, Matteucci, Francesca
openaire   +2 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Watching Our Galaxy Grow Up: The Mass and Color Evolution of the Milky Way

The Astrophysical Journal
Using our rich observations within the Milky Way to better understand galaxy evolution requires understanding what the Milky Way looks like “as a galaxy”—that is, its “true” shape and abundance profiles (unskewed by observational biases), signatures of ...
Gail Zasowski, Julie Imig, Hayley Coluccio   +2 more
doaj   +1 more source