Results 81 to 90 of about 77,216 (325)

The Age of the Milky Way Inner Halo

, 2012
The Milky Way galaxy is observed to have multiple components with distinct properties, such as the bulge, disk, and halo. Unraveling the assembly history of these populations provides a powerful test to the theory of galaxy formation and evolution, but ...
A Dotter, A Dotter, A Dotter, A Renzini, A Sarajedini, A Zolotov, AS Font, B Paczyński, BR Oppenheimer, D Carollo, DR Soderblom, E Gates, E-M Pauli, G Wegner, Jason S. Kalirai, JS Kalirai, JS Kalirai, JS Kalirai, JS Kalirai, LR Bedin, M Kilic, P Bergeron, P Jofré, P-E Tremblay, P-E Tremblay, R Napiwotzki, S Moehler, SL Shapiro, TC Beers   +28 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Watching Our Galaxy Grow Up: The Mass and Color Evolution of the Milky Way

The Astrophysical Journal
Using our rich observations within the Milky Way to better understand galaxy evolution requires understanding what the Milky Way looks like “as a galaxy”—that is, its “true” shape and abundance profiles (unskewed by observational biases), signatures of ...
Gail Zasowski, Julie Imig, Hayley Coluccio   +2 more
doaj   +1 more source

The Gaia-ESO Survey: Chemical evolution of Mg and Al in the Milky Way with Machine-Learning [PDF]

, 2022
M. Ambrosch, G. Guiglion, Š. Mikolaitis, C. Chiappini, G. Tautvaišienė, S. Nepal, G. Gilmore, S. Randich, T. Bensby, M. Bergemann, L. Morbidelli, E. Pancino, G. G. Sacco, R. Smiljanić, S. Zaggia, P. Jofré, F. Jiménez-Esteban   +16 more
openalex   +1 more source

The chemodynamical evolution of the Milky Way disc -- A new modeling approach

, 2013
Despite the recent advancements in the field of galaxy formation and evolution, fully self-consistent simulations are still unable to make the detailed predictions necessary for the planned and ongoing large spectroscopic and photometry surveys of the ...
Chiappini, Cristina, Martig, Marie, Minchev, Ivan   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Stellar Disk Structure Revealed by the Mono-age Populations of the LAMOST Red Clump Star Sample

The Astronomical Journal
Understanding the structure of the Galactic disk is crucial for understanding the formation and evolutionary history of the Milky Way. This study examines the structure of the Galactic disk by analyzing a sample of 138,667 primary red clump (RC) stars ...
Zheng Yu, Bingqiu Chen, Jianhui Lian, Chun Wang, Xiaowei Liu   +4 more
doaj   +1 more source

Chemical Evolution of the Milky Way and Its Satellites [PDF]

, 2014
To appear on the Proceedings of the 37th Saas-Fee Advanced Course of the Swiss Society for Astrophysics and Astronomy, " The Origin of the Galaxy and the Local Group", eds. E. Grebel and B.
openaire   +2 more sources

The Milky Way evolution under the RAVE perspective [PDF]

Proceedings of the International Astronomical Union, 2015
AbstractThe RAdial Velocity Experiment (RAVE) collected from 2003 to 2013 medium resolution spectra for 5ċ105 low-mass stars of our Galaxy, improving our understanding of the Milky Way evolution and of its properties outside the Solar neighbourhood. This proceeding gives an overview of RAVE results obtained in the last two years.
openaire   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source