Results 81 to 90 of about 77,093 (285)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Watching Our Galaxy Grow Up: The Mass and Color Evolution of the Milky Way

The Astrophysical Journal
Using our rich observations within the Milky Way to better understand galaxy evolution requires understanding what the Milky Way looks like “as a galaxy”—that is, its “true” shape and abundance profiles (unskewed by observational biases), signatures of ...
Gail Zasowski, Julie Imig, Hayley Coluccio   +2 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

What Is Missing from the Local Stellar Halo?

The Astrophysical Journal
The Milky Way’s stellar halo, which extends to >100 kpc, encodes the evolutionary history of our Galaxy. However, most studies of the halo to date have been limited to within a few kiloparsecs of the Sun.
Katherine Sharpe, Rohan P. Naidu, Charlie Conroy   +2 more
doaj   +1 more source

The Age of the Milky Way Inner Halo

, 2012
The Milky Way galaxy is observed to have multiple components with distinct properties, such as the bulge, disk, and halo. Unraveling the assembly history of these populations provides a powerful test to the theory of galaxy formation and evolution, but ...
A Dotter, A Dotter, A Dotter, A Renzini, A Sarajedini, A Zolotov, AS Font, B Paczyński, BR Oppenheimer, D Carollo, DR Soderblom, E Gates, E-M Pauli, G Wegner, Jason S. Kalirai, JS Kalirai, JS Kalirai, JS Kalirai, JS Kalirai, LR Bedin, M Kilic, P Bergeron, P Jofré, P-E Tremblay, P-E Tremblay, R Napiwotzki, S Moehler, SL Shapiro, TC Beers   +28 more
core   +1 more source

Chemical Evolution of the Milky Way and Its Satellites [PDF]

, 2014
To appear on the Proceedings of the 37th Saas-Fee Advanced Course of the Swiss Society for Astrophysics and Astronomy, " The Origin of the Galaxy and the Local Group", eds. E. Grebel and B.
openaire   +2 more sources

The Milky Way evolution under the RAVE perspective [PDF]

Proceedings of the International Astronomical Union, 2015
AbstractThe RAdial Velocity Experiment (RAVE) collected from 2003 to 2013 medium resolution spectra for 5ċ105 low-mass stars of our Galaxy, improving our understanding of the Milky Way evolution and of its properties outside the Solar neighbourhood. This proceeding gives an overview of RAVE results obtained in the last two years.
openaire   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

The Milky Way’s Rowdy Neighbors: The Effects of the Large Magellanic Cloud and Sagittarius Dwarf on the Milky Way Disk

The Astrophysical Journal
The Milky Way (MW) is a barred spiral galaxy shaped by tidal interactions with its satellites. The Large Magellanic Cloud (LMC) and the Sagittarius dwarf galaxy (Sgr) are the dominant influences at the present day. This paper presents a suite of four 10 ^
Ioana A. Stelea, Jason A. S. Hunt, Kathryn V. Johnston   +2 more
doaj   +1 more source

The Chemical Evolution of the Milky Way Galaxy

, 2021
The elemental abundance gradients of elements up to Zn are predicted using the N body Monte Carlo technique by developing homogenous and heterogeneous Galactic Chemical Evolution (GCE) simulations. In the case of homogeneous GCE models, the galaxy is radially divided into eight annular rings of 2 kpc width each at a distance of 2-18 kpc from the center
openaire   +1 more source