Results 51 to 60 of about 92,409 (330)

The formation and early evolution of the Milky Way [PDF]

Symposium - International Astronomical Union, 1985
In broad outline, the traditional picture for the formation of the Milky Way can be summarized as follows. The proto-galaxy consisted of a slowly rotating cloud of metal-free gas that cooled by bremsstrahlung and recombination radiation. As the internal pressure of the gas decreased, it collapsed in stages with smaller dimensions, faster rotation ...
openaire   +1 more source

Star Formation in the Milky Way and Nearby Galaxies

, 2012
We review progress over the past decade in observations of large-scale star formation, with a focus on the interface between extragalactic and Galactic studies.
Altenhoff WJ, Bacmann A, Blanc GA, Bronfman L, Bronfman L, Buat V, Casassus S, Cesaroni R, Christlein D, Draine BT, Gavazzi G, Glover SCO, Goddard QE, Hunter DA, Koda J, Koribalski BS, Kramer C, Laurent O, Motte F, Mouschovias TCh, Neal J. Evans, Niklas S, Perault M, Reipurth B, Robert C. Kennicutt, Ruphy S, Stahler SW, Stutzki J, Wouterloot JGA, Zasov AV   +29 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

THE STAR FORMATION HISTORY OF THE MILKY WAY'S NUCLEAR STAR CLUSTER [PDF]

The Astrophysical Journal, 2011
ApJ accepted, 17 figures, 3 ...
Pfuhl, O., Fritz, T., Zilka, M., Maness, H., Eisenhauer, F., Genzel, R., Gillessen, S., Ott, T., Dodds-Eden, K., Sternberg, A.   +9 more
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Milky Way as a Star Formation Engine [PDF]

, 2014
The cycling of material from the interstellar medium (ISM) into stars and the return of stellar ejecta into the ISM is the engine that drives the "galactic ecology" in normal spirals, a cornerstone in the formation and evolution of galaxies through cosmic time.
Molinari, S., Bally, J., Glover, S., Moore, T., Noriega-Crespo, A., Plume, R., Testi, L., Vázquez-Semadeni, E., Zavagno, A., Bernard, J. -P., Martin, P.   +10 more
openaire   +3 more sources

Predicting the locations of possible long-lived low-mass first stars: Importance of satellite dwarf galaxies

, 2017
The search for metal-free stars has so far been unsuccessful, proving that if there are surviving stars from the first generation, they are rare, they have been polluted, or we have been looking in the wrong place.
Agarwal, Bhaskar, Frebel, Anna, Glover, Simon C. O., Griffen, Brendan F., Hartwig, Tilman, Klessen, Ralf S., Magg, Mattis   +6 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Additional Evidence for the Existence of a Primordial Disk System

The Astrophysical Journal
The origin of very metal-poor (VMP; [Fe/H] ≤ −2.0) stars on planar orbits has been the subject of great attention since their first discovery. However, prior to the release of the Gaia BP/RP (XP) spectra and large photometric samples such as SkyMapper ...
Shuai Xu, Haibo Yuan, Bowen Huang, Timothy C. Beers, Yang Huang, Maosheng Xiang, Kai Xiao, Jihye Hong, Young Sun Lee, Wuming Yang   +9 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source