Results 51 to 60 of about 8,242 (260)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

The Milky Way and other spiral galaxies

EPJ Web of Conferences, 2012
Cosmologists have often considered the Milky Way as a typical spiral galaxy, and its properties have considerably influenced the current scheme of galaxy formation.
Wang J.L., Yang Y.B., Flores H., Puech M., Hammer F., Fouquet S.   +5 more
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Estimating the Initial Mass of the Gaia–Enceladus Dwarf Galaxy with a Chemical Evolution Model

The Astrophysical Journal
This work investigates the initial mass and chemical evolution history of the Gaia–Enceladus dwarf galaxy. We combine spectroscopic data from APOGEE with astrometric data from Gaia Data Release 3 to identify Gaia–Enceladus candidate stars via a machine ...
Olcay Plevne, Furkan Akbaba
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The Extremely Metal-rich Knot of Stars at the Heart of the Galaxy

The Astrophysical Journal
We show with Gaia XP spectroscopy that extremely metal-rich (EMR) stars in the Milky Way ([M/H] _XP ≳ 0.5) are largely confined to a tight “knot” at the center of the Galaxy. This EMR knot is round in projection, has a fairly abrupt edge near R _GC,proj ∼
Hans-Walter Rix, Vedant Chandra, Gail Zasowski, Annalisa Pillepich, Sergey Khoperskov, Sofia Feltzing, Rosemary F. G. Wyse, Neige Frankel, Danny Horta, Juna Kollmeier, Keivan Stassun, Melissa K. Ness, Jonathan C. Bird, David Nidever, José G. Fernández-Trincado, João A. S. Amarante, Chervin F. P. Laporte, Jianhui Lian   +17 more
doaj   +1 more source

Molecular gas and star formation in the Milky Way

EPJ Web of Conferences, 2012
The dense molecular gas is the ideal tracer of the spiral structure in the Milky Way, and should be used intensively to solve the puzzle of its structure. In spite of our position inside the plane, we can hope to disentangle the structures, with position-
Combes F.
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source