Results 71 to 80 of about 52,093 (177)
In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators
British Journal of Pharmacology, Volume 182, Issue 24, Page 6063-6080, December 2025.Background and Purpose
Cystic fibrosis (CF) is due to loss‐of‐function variants of the CF transmembrane conductance regulator (CFTR) channel. The most effective treatment for people with CF carrying the F508del mutation is the triple combination of elexacaftor–tezacaftor–ivacaftor (ETI).Emanuela Pesce, Valeria Tomati, Valeria Capurro, Mariateresa Lena, Cristina Pastorino, Miro Astore, Serdar Kuyucak, Benoit Chevalier, Elvira Sondo, Federico Cresta, Alice Dighero, Vito Terlizzi, Cristina Fevola, Stefano Costa, Maria Cristina Lucanto, Valeria Daccò, Laura Claut, Francesca Ficili, Benedetta Fabrizzi, Renata Bocciardi, Federico Zara, Carlo Castellani, Luis J. V. Galietta, Shafagh A. Waters, Alexandre Hinzpeter, Nicoletta Pedemonte +25 morewiley +1 more sourceThe Star-Forming Galaxy Contribution to the Cosmic MeV and GeV Gamma-Ray
Background
, 2014 While star-forming galaxies could be major contributors to the cosmic GeV
$\gamma$-ray background, they are expected to be MeV-dim because of the "pion
bump" falling off below ~100 MeV.Abdo, Abdo, Abdo, Abdo, Abramowski, Ackermann, Ackermann, Agaronyan, Aharonian, Aharonian, Ajello, Ajello, Akyuz, Appleton, Baldry, Berezhko, Bertone, Bhattacharya, Bloemen, Bloemen, Bloemen, Bloser, Bouchet, Bouchet, Bouchet, Brian C. Lacki, Broderick, Béthermin, Böttcher, Cappi, Carilli, Catchpole, Chakraborty, Chang, Chapman, Chomiuk, Chugai, Colafrancesco, Connell, Coppi, Dar, de Cea del Pozo, de Cea del Pozo, del Rio, Dermer, Dermer, Diehl, Ellison, Everett, Faucher-Giguère, Feldmann, Fields, Finke, Ginzburg, Goetz, Golla, Greiner, Hamuy, Hayashida, Hopkins, Horiuchi, Horiuchi, Hunter, Indriolo, Inoue, Inoue, Inoue, Inoue, Iyudin, John F. Beacom, Jose, Kamae, Kennicutt, Keshet, Keshet, Klein, Knödlseder, Knödlseder, Kochanek, Kovács, Kozlovsky, Lacki, Lacki, Lacki, Lacki, Lien, Limongi, Loeb, Makiya, Malkov, Malyshev, Mao, Massaro, Melo, Meneguzzi, Meyer, Miniati, Moskalenko, Murase, Murphy, Murray, Nagashima, Nagashima, Nolan, Ohm, Olive, Ore, Padovani, Paglione, Pavlidou, Pavlidou, Pavlidou, Pohl, Porter, Prodanović, Robitaille, Rodighiero, Ruiz-Lapuente, Sacher, Sanders, Sargent, Sargent, Schlickeiser, Schlickeiser, Shunsaku Horiuchi, Singal, Sironi, Soltan, Soltan, Sreekumar, Stanek, Stecker, Stecker, Strickland, Strigari, Strong, Strong, Strong, Strong, Strong, Strong, Teegarden, Teng, Thompson, Thompson, Thompson, Torres, Torres, Ullio, Venters, Vink, Völk, Warren, Watanabe, Wdowczyk, Webber, Webber, Williams, Williams, Yoast-Hull, Yoast-Hull, Yun, Zhang, Zhou +163 morecore +1 more sourceDELVE Milky Way Satellite Galaxy Census. I. Satellite Population and Survey Selection Function in DES, DELVE, and Pan-STARRS
The Astrophysical JournalThe properties of Milky Way satellite galaxies have important implications for galaxy formation, reionization, and the fundamental physics of dark matter.C. Y. Tan, A. Drlica-Wagner, A. B. Pace, W. Cerny, E. O. Nadler, A. Doliva-Dolinsky, D. Anbajagane, T. S. Li, J. D. Simon, A. K. Vivas, A. R. Walker, M. Adamów, K. Bechtol, J. L. Carlin, Q. O. Casey, C. Chang, A. Chaturvedi, T.-Y. Cheng, A. Chiti, Y. Choi, D. Crnojević, P. S. Ferguson, R. A. Gruendl, A. P. Ji, G. Limberg, G. E. Medina, B. Mutlu-Pakdil, N. E. D. Noël, K. Overdeck, V. M. Placco, A. H. Riley, D. J. Sand, J. Sharp, N. F. Sherman, G. S. Stringfellow, R. H. Wechsler, M. Aguena, S. Allam, O. Alves, D. Bacon, D. Brooks, D. L. Burke, R. Camilleri, J. A. Carballo-Bello, A. Carnero Rosell, J. Carretero, L. N. da Costa, M. E. da Silva Pereira, T. M. Davis, J. De Vicente, S. Desai, S. Everett, B. Flaugher, J. Frieman, J. García-Bellido, D. Gruen, G. Gutierrez, K. Herner, S. R. Hinton, D. L. Hollowood, D. J. James, K. Kuehn, O. Lahav, S. Lee, J. L. Marshall, C. E. Martínez-Vázquez, P. Massana, J. Mena-Fernández, R. Miquel, J. Muir, J. Myles, R. L. C. Ogando, A. A. Plazas Malagón, A. Porredon, E. Sanchez, D. Sanchez Cid, I. Sevilla-Noarbe, M. Smith, E. Suchyta, M. E. C. Swanson, C. To, E. J. Tollerud, D. L. Tucker, V. Vikram, N. Weaverdyck, M. Yamamoto, A. Zenteno, (DELVE and DES Collaborations) +87 moredoaj +1 more sourceHeated Disc Stars in the Stellar Halo
, 2010 Minor accretion events with mass ratio M_sat : M_host ~ 1:10 are common in
the context of LCDM cosmology. We use high-resolution simulations of
Galaxy-analogue systems to show that these mergers can dynamically eject disk
stars into a diffuse light ...Abadi, Abadi, Abe, Allen, Bell, Benson, Blaauw, Brook, Brook, Bullock, Bullock, Bullock, Carollo, Chapman, Chiba, Chris W. Purcell, Conroy, Côté, de Jong, De Lucia, Durrell, Fardal, Ferguson, Ferguson, Font, Gilbert, Gilbert, Governato, Gratton, Greenstein, Gualandris, Hammer, Helmi, Hills, Ibata, Ibata, James S. Bullock, Johnston, Johnston, Kalirai, Katz, Kazantzidis, Kazantzidis, Keenan, Khochfar, Kinman, Koch, Kuijken, Lequeux, Macciò, Martin, McConnachie, McConnachie, Minniti, Morrison, Moster, Navarro, Perets, Purcell, Purcell, Purcell, Purcell, Ramspeck, Read, Richardson, Sackett, Sandage, Searle, Siegel, Starkenburg, Stelios Kazantzidis, Stewart, Stinson, Stinson, van Zee, Velazquez, Villalobos, Wadsley, Weinberg, Widrow, Yoachim, Yoachim, Yu, Zentner, Zibetti, Zibetti, Zolotov +86 morecore +1 more sourceMid-infrared Extinction toward the Galactic Center
The Astrophysical JournalWe determine the mid-infrared (MIR, ∼5–22 μ m) extinction toward the Galactic center using MIRI/Medium-Resolution Spectrometer (MRS) integral field unit observations of the central 3″ × 3″ region (near 5 μ m) to 7″ × 7″ region (near 22 μ m).Sebastiano D. von Fellenberg, Joseph M. Michail, S. P. Willner, Braden Seefeldt-Gail, Tamojeet Roychowdhury, Macarena Garcia Marin, Giovanni G. Fazio, Nicole M. Ford, Daryl Haggard, Joseph L. Hora, Howard A. Smith, Zach Sumners, Gunther Witzel +12 moredoaj +1 more sourceChecking the dark matter origin of 3.53 keV line with the Milky Way
center
, 2015 We detect a line at 3.539 +/- 0.011 keV in the deep exposure dataset of the
Galactic Center region, observed with the XMM-Newton. The dark matter
interpretation of the signal observed in the Perseus galaxy cluster, the
Andromeda galaxy [1402.4119] and in Boyarsky, Alexey, Franse, Jeroen, Iakubovskyi, Dmytro, Ruchayskiy, Oleg +3 morecore +1 more sourceNew Arabic Records From Cairo on Supernovae 1181 and 1006
Astronomische Nachrichten, Volume 346, Issue 9, November 2025.ABSTRACT
The remnant of the historical supernova SN 1181 is under discussion: While the previously suggested G130.7+3.1 (3C58) appears too old (3000–5000 year), the unusual star IRAS00500+6713 with a surrounding nebula (Pa‐30) has an expansion age not inconsistent with a SN Iax explosion in ad 1181 under the assumption that neither acceleration nor ...J. G. Fischer, H. Halm, R. Neuhäuser, D. L. Neuhäuser +3 morewiley +1 more sourceIntroducing the DREAMS Project: DaRk mattEr and Astrophysics with Machine Learning and Simulations
The Astrophysical JournalWe introduce the DaRk mattEr and Astrophysics with Machine learning and Simulations (DREAMS) project, an innovative approach to understanding the astrophysical implications of alternative dark matter (DM) models and their effects on galaxy formation and ...Jonah C. Rose, Paul Torrey, Francisco Villaescusa-Navarro, Mariangela Lisanti, Tri Nguyen, Sandip Roy, Kassidy E. Kollmann, Mark Vogelsberger, Francis-Yan Cyr-Racine, Mikhail V. Medvedev, Shy Genel, Daniel Anglés-Alcázar, Nitya Kallivayalil, Bonny Y. Wang, Belén Costanza, Stephanie O’Neil, Cian Roche, Soumyodipta Karmakar, Alex M. Garcia, Ryan Low, Shurui Lin, Olivia Mostow, Akaxia Cruz, Andrea Caputo, Arya Farahi, Julian B. Muñoz, Lina Necib, Romain Teyssier, Julianne J. Dalcanton, David Spergel +29 moredoaj +1 more source
