Results 111 to 120 of about 30,917 (286)

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

A Novel Approach to Identifying Substructures through Analysis of Metallicity Distribution Functions

The Astrophysical Journal
We present a new method for identifying Galactic halo substructures accreted from dwarf galaxies by combining metallicity distribution functions (MDFs) with orbital parameters.
Young Kwang Kim, Young Sun Lee, Timothy C. Beers   +2 more
doaj   +1 more source

The assembly of the halo system of the Milky Way as revealed by SDSS/SEGUE – The CEMP star connection

EPJ Web of Conferences, 2012
In recent years, massive new spectroscopic data sets, such as the over half million stellar spectra obtained during the course of SDSS (in particular its sub-survey SEGUE), have provided the quantitative detail required to formulate a coherent story of ...
Carollo D., Beers T.C.
doaj   +1 more source

Testing two alternatives theories to dark matter with the Milky Way dynamics

, 2015
Two alternative theories to dark matter are investigated by testing their ability to describe consistently the dynamics of the Milky Way. The first one refers to a modified gravity theory having a running gravitational constant and the second assumes ...
de Oliveira, P. L. C., Pacheco, J. A. de Freitas, Reinisch, G.   +2 more
core   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Predictions for the Detectability of Milky Way Satellite Galaxies and Outer-Halo Star Clusters with the Vera C. Rubin Observatory

The Open Journal of Astrophysics
We predict the sensitivity of the Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) to faint, resolved Milky Way satellite galaxies and outer-halo star clusters.
Kabelo Tsiane, Sidney Mau, Alex Drlica-Wagner, Jeffrey L. Carlin, Peter S. Ferguson, Keith Bechtol, Ethan O. Nadler, Annika H. G. Peter, Yao-Yuan Mao, Adam J. Thornton, LSST Dark Energy Science Collaboration   +10 more
doaj   +1 more source

Constraining the primordial initial mass function with stellar archaeology

, 2015
We present a new near-field cosmological probe of the initial mass function (IMF) of the first stars. Specifically, we constrain the lower-mass limit of the Population III (Pop III) IMF with the total number of stars in large, unbiased surveys of the ...
Bromm, Volker, Glover, Simon C. O., Hartwig, Tilman, Klessen, Ralf S.   +3 more
core   +2 more sources

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

All-sky Kinematics of the Distant Halo: The Reflex Response to the LMC

The Astrophysical Journal
The infall of the Large Magellanic Cloud (LMC) is predicted to displace the inner Milky Way (MW), imprinting an apparent “reflex motion” on the observed velocities of distant halo stars. We construct the largest all-sky spectroscopic data set of luminous
Vedant Chandra, Rohan P. Naidu, Charlie Conroy, Nicolas Garavito-Camargo, Chervin Laporte, Ana Bonaca, Phillip A. Cargile, Emily Cunningham, Jiwon Jesse Han, Benjamin D. Johnson, Hans-Walter Rix, Yuan-Sen Ting, Rebecca Woody, Dennis Zaritsky   +13 more
doaj   +1 more source

Bright gamma-ray Galactic Center excess and dark dwarfs: Strong tension for dark matter annihilation despite Milky Way halo profile

, 2016
We incorporate Milky Way dark matter halo profile uncertainties, as well as an accounting of diffuse gamma-ray emission uncertainties in dark matter annihilation models for the Galactic Center Extended gamma-ray excess (GCE) detected by the Fermi Gamma ...
Abazajian, Kevork N., Keeley, Ryan E.
core   +1 more source