Results 111 to 120 of about 589 (260)

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Chemical Diversity on Small Scales: Abundance Analysis of the Tucana V Ultrafaint Dwarf Galaxy

The Astrophysical Journal
The growing number of Milky Way satellites detected in recent years has introduced a new focus for stellar abundance analysis. Abundances of stars in satellites have been used to probe the nature of these systems and their chemical evolution.
Terese T. Hansen, Joshua D. Simon, Ting S. Li, Domani Sharkey, Alexander P. Ji, Ian B. Thompson, Henrique M. Reggiani, Jhon Yana Galarza   +7 more
doaj   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Detection of the Actinide Th in an r-process-enhanced Star with Accretion Origin

The Astrophysical Journal
The thorium and six second-peak r -process element (56 ≤ Z ≤ 72) abundances are determined for the α -poor star LAMOST J1124+4535 based on a high-resolution spectrum obtained with the High Dispersion Spectrograph on the Subaru Telescope. The age of J1124+
Qianfan Xing, Gang Zhao, Wako Aoki, Haining Li, Jingkun Zhao, Tadafumi Matsuno, Takuma Suda   +6 more
doaj   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

A New Tidal Stream Discovered in Gaia DR3

The Astrophysical Journal
Thanks to the precise astrometric measurements of proper motions by the Gaia mission, a new tidal stellar stream has been discovered in the northern hemisphere. The distribution of star count shows that the stream is approximately 80° long and 1.°70 wide.
Hao Tian, Chao Liu, Changqing Luo, Xiang-Xiang Xue, Yujiao Yang   +4 more
doaj   +1 more source

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

The Velocity Field of Our Milky Way Outer Stellar Halo Based on DESI DR2

The Astrophysical Journal
Using 64,000 halo K giants from the Dark Energy Spectroscopic Instrument second Data Release (DR2), we decompose the Milky Way (MW) stellar halo between 3 and 160 kpc into metal-rich (MR) and metal-poor (MP) components via a Gaussian mixture model.
Songting Li, Wenting Wang, Sergey E. Koposov, João A. S. Amarante, Alis J. Deason, Monica Valluri, Ting S. Li, Amanda Byström, Mika Lambert, Tian Qiu, Joan Najita, Gustavo E. Medina, Oleg Y. Gnedin, Leandro Beraldo e Silva, Richard A. N. Brooks, Raymond G. Carlberg, Namitha Kizhuprakkat, Jiaxin Han, Jessica Nicole Aguilar, Steven Ahlen, Davide Bianchi, David Brooks, Todd Claybaugh, Andrei Cuceu, Axel de la Macorra, Peter Doel, Andreu Font-Ribera, Jaime E. Forero-Romero, Simone Ferraro, Enrique Gaztañaga, Satya Gontcho A Gontcho, Gaston Gutierrez, Julien Guy, Klaus Honscheid, Dick Joyce, Anthony Kremin, Martin Landriau, Laurent Le Guillou, Aaron Meisner, Ramon Miquel, John Moustakas, Seshadri Nadathur, Will Percival, Francisco Prada, Ignasi Pérez-Ràfols, Graziano Rossi, Eusebio Sanchez, David Schlegel, Michael Schubnell, Ray Sharples, Joseph Harry Silber, David Sprayberry, Gregory Tarlé, Benjamin Alan Weaver, Rongpu Zhou, Hu Zou   +55 more
doaj   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Statistical Predictions of the Accreted Stellar Halos around Milky Way-Like Galaxies

The Open Journal of Astrophysics
In the $Λ$CDM paradigm, stellar halos form through the accretion and disruption of satellite galaxies. We introduce new semi-analytic modeling within the SatGen framework to track the ex-situ stellar components of Milky Way--like galaxies across large ...
J. Sebastian Monzon, Frank C. van den Bosch, Martin P. Rey   +2 more
doaj   +1 more source