Results 121 to 130 of about 5,772,490 (206)

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Mapping the Distant and Metal-poor Milky Way with SDSS-V

The Astrophysical Journal
The fifth-generation Sloan Digital Sky Survey (SDSS-V) is conducting the first all-sky low-resolution spectroscopic survey of the Milky Way’s (MW) stellar halo.
Vedant Chandra, Phillip A. Cargile, Alexander P. Ji, Charlie Conroy, Hans-Walter Rix, Emily Cunningham, Bruno Dias, Chervin Laporte, William Cerny, Guilherme Limberg, Avrajit Bandyopadhyay, Ana Bonaca, Andrew R. Casey, John Donor, José G. Fernández-Trincado, Peter M. Frinchaboy, Pramod Gupta, Keith Hawkins, Jennifer A. Johnson, Juna A. Kollmeier, Madeline Lucey, Ilija Medan, Szabolcs Mészáros, Sean Morrison, José Sánchez-Gallego, Andrew K. Saydjari, Conor Sayres, Kevin C. Schlaufman, Keivan G. Stassun, Jamie Tayar, Zachary Way   +30 more
doaj   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

The Rotating Bulge and Halo in the Milky Way: Evidence of Angular Momentum Transferred from the Decelerating Bar

The Astrophysical Journal
Recent observations indicate that both the Milky Way bulge and inner halo exhibit angular momentum, although the origin and evolution of this prograde signature remain ambiguous.
Zhuohan Li, Chengdong Li, Gang Zhao, Ruizhi Zhang, Xiang-Xiang Xue   +4 more
doaj   +1 more source

A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle

Advanced Science, EarlyView.
This study identified a mitochondrial micropeptide encoded by a non‐canonical open reading frame (alt‐ORF) within the CTSB gene. This micropeptide named APPM (ATP production‐promoting micropeptide) is a novel component of the OGDHc complex in the TCA cycle. APPM localizes to the inner mitochondrial membrane and directly binds to OGDH, the E1 subunit of
Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu   +9 more
wiley   +1 more source

Inferring Stellar Densities with Flexible Models. I. The Distribution of RR Lyrae in the Milky Way with Gaia DR3

The Astronomical Journal
Understanding the formation and evolutionary history of the Milky Way requires detailed mapping of its stellar components, which preserve fossil records of the Galaxy’s assembly through cosmic time.
Madeline Lucey, Cecilia Mateu, Adrian M. Price-Whelan, David W. Hogg, Hans-Walter Rix, Robyn E. Sanderson   +5 more
doaj   +1 more source

The evolution of dark matter substructure [PDF]

, 2001
This thesis investigates the dynamical evolution of systems orbiting within deeper potentials. Initially we use a simple satellite-halo interaction to study the dynamical processes that act on orbiting systems and we compare these results to analytical ...
Roldán, Carlos Antonio Calcáneo
core  

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

Tidal Debris Candidates from the ω Centauri Accretion Event and Its Role Building Up the Milky Way Halo

The Astrophysical Journal
We identify stellar tidal debris from the ω Centauri ( ω Cen) system among field stars in the Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey via chemical tagging using a neural network trained on APOGEE observations of the ω Cen ...
Borja Anguiano, Arik W. Mitschang, Takanobu Kirihara, Yutaka Hirai, Danny Horta, Sten Hasselquist, Ricardo P. Schiavon, Steven R. Majewski, Andrew C. Mason, Adrian M. Price-Whelan, Carlos Allende Prieto, Verne V. Smith, Katia Cunha, David L. Nidever   +13 more
doaj   +1 more source