Results 121 to 130 of about 30,917 (286)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Constraining the Milky Way Halo Accretion History with Simulated Stellar Halos: Designing the HALO7D-X Survey

The Astrophysical Journal
We present the design for HALO7D-X, a survey of the stellar halo to investigate the accretion history of the Milky Way. The survey will use a combination of Hubble Space Telescope (HST) and Gaia data for sky position and proper motions of faint stars (18 
Miranda Apfel, Kevin McKinnon, Constance M. Rockosi, Puragra Guhathakurta, Kathryn V. Johnston   +4 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Disk Heating, Galactoseismology, and the Formation of Stellar Halos

Galaxies, 2017
Deep photometric surveys of the Milky Way have revealed diffuse structures encircling our Galaxy far beyond the “classical” limits of the stellar disk. This paper reviews results from our own and other observational programs, which together suggest that,
Kathryn V. Johnston, Adrian M. Price-Whelan, Maria Bergemann, Chervin Laporte, Ting S. Li, Allyson A. Sheffield, Steven R. Majewski, Rachael S. Beaton, Branimir Sesar, Sanjib Sharma   +9 more
doaj   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Using the Two-point Correlation Function to Understand the Assembly Histories of Milky Way–like Galaxies

The Astrophysical Journal
The two-point correlation function (2PCF) is a powerful statistical tool to measure galaxy clustering. Although 2PCF has also been used to study the clustering of stars on subparsec to kiloparsec scales, its physical implication is not clear.
Yike Zhang, Wenting Wang, Jiaxin Han, Xiaohu Yang, Vicente Rodriguez-Gomez, Carles G. Palau, Zhenlin Tan   +6 more
doaj   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Figuring Out Gas and Galaxies in Enzo (FOGGIE). VII. The (Dis)assembly of Stellar Halos

The Astrophysical Journal
Over the next decade, the astronomical community will be commissioning multiple wide-field observatories well suited for studying stellar halos in both integrated light and resolved stars. In preparation for this, we use five high-resolution cosmological
Anna C. Wright, Jason Tumlinson, Molly S. Peeples, Brian W. O’Shea, Cassandra Lochhaas, Lauren Corlies, Britton D. Smith, Nguyen Binh, Ramona Augustin, Raymond C. Simons   +9 more
doaj   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Chemical Diversity on Small Scales: Abundance Analysis of the Tucana V Ultrafaint Dwarf Galaxy

The Astrophysical Journal
The growing number of Milky Way satellites detected in recent years has introduced a new focus for stellar abundance analysis. Abundances of stars in satellites have been used to probe the nature of these systems and their chemical evolution.
Terese T. Hansen, Joshua D. Simon, Ting S. Li, Domani Sharkey, Alexander P. Ji, Ian B. Thompson, Henrique M. Reggiani, Jhon Yana Galarza   +7 more
doaj   +1 more source