Results 101 to 110 of about 589 (260)

Constraining the Milky Way Halo Accretion History with Simulated Stellar Halos: Designing the HALO7D-X Survey

The Astrophysical Journal
We present the design for HALO7D-X, a survey of the stellar halo to investigate the accretion history of the Milky Way. The survey will use a combination of Hubble Space Telescope (HST) and Gaia data for sky position and proper motions of faint stars (18 
Miranda Apfel, Kevin McKinnon, Constance M. Rockosi, Puragra Guhathakurta, Kathryn V. Johnston   +4 more
doaj   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Using the Two-point Correlation Function to Understand the Assembly Histories of Milky Way–like Galaxies

The Astrophysical Journal
The two-point correlation function (2PCF) is a powerful statistical tool to measure galaxy clustering. Although 2PCF has also been used to study the clustering of stars on subparsec to kiloparsec scales, its physical implication is not clear.
Yike Zhang, Wenting Wang, Jiaxin Han, Xiaohu Yang, Vicente Rodriguez-Gomez, Carles G. Palau, Zhenlin Tan   +6 more
doaj   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

The assembly of the halo system of the Milky Way as revealed by SDSS/SEGUE – The CEMP star connection

EPJ Web of Conferences, 2012
In recent years, massive new spectroscopic data sets, such as the over half million stellar spectra obtained during the course of SDSS (in particular its sub-survey SEGUE), have provided the quantitative detail required to formulate a coherent story of ...
Carollo D., Beers T.C.
doaj   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

The Milky Way Tomography with Subaru Hyper Suprime-Cam: Possible Implications for the Past Orbit of the Large Magellanic Cloud

The Astrophysical Journal Letters
We report the discovery of diffuse stellar substructure in the outer halo of the Milky Way (MW) toward Boötes, unveiled by deep imaging data of the Subaru/Hyper Suprime-Cam.
Yoshihisa Suzuki, Masashi Chiba, Rosemary F. G. Wyse   +2 more
doaj   +1 more source

Dynamic Regulation of Endogenous Transcription Factor Hubs at Single‐Molecule Resolution

Advanced Science, EarlyView.
This study combines single‐molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms neomorphic hubs that dynamically assemble and dissolve. The hubs are regulated during mitosis, by RNA, and by specific chemicals.
Shawn Yoshida, Yanghao Zhong, Akiko Kumagai, William G. Dunphy, Shasha Chong   +4 more
wiley   +1 more source

Figuring Out Gas and Galaxies in Enzo (FOGGIE). VII. The (Dis)assembly of Stellar Halos

The Astrophysical Journal
Over the next decade, the astronomical community will be commissioning multiple wide-field observatories well suited for studying stellar halos in both integrated light and resolved stars. In preparation for this, we use five high-resolution cosmological
Anna C. Wright, Jason Tumlinson, Molly S. Peeples, Brian W. O’Shea, Cassandra Lochhaas, Lauren Corlies, Britton D. Smith, Nguyen Binh, Ramona Augustin, Raymond C. Simons   +9 more
doaj   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source