Results 51 to 60 of about 700 (297)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

On the Corotation of Milky Way Satellites: LMC-mass Satellites Induce Apparent Motions in Outer Halo Tracers

The Astrophysical Journal
Understanding the physical mechanism behind the formation of a corotating thin plane of satellite galaxies, like the one observed around the Milky Way (MW), has been challenging.
Nicolás Garavito-Camargo, Adrian M. Price-Whelan, Jenna Samuel, Emily C. Cunningham, Ekta Patel, Andrew Wetzel, Kathryn V. Johnston, Arpit Arora, Robyn E. Sanderson, Lehman Garrison, Danny Horta   +10 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Deciphering the Kinematic Substructure of Local Dark Matter with LAMOST K Giants

The Astrophysical Journal
Numerical simulations indicate that correlations exist between the velocity distributions of stars and dark matter (DM). We study the local DM velocity distribution based on these correlations.
Hai Zhu, Rui Guo, Juntai Shen, Jianglai Liu, Chao Liu, Xiang-Xiang Xue, Lan Zhang, Shude Mao   +7 more
doaj   +1 more source

Using frequency maps to explore the distribution function of the Milky Way stellar halo

EPJ Web of Conferences, 2012
Resolved surveys of the Milky Way's stellar halo can obtain all 6 phase space coordinates of tens of thousands of individual stars, making it possible to compute their 3-dimensional orbits.
Valluri M.
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The R-Process Alliance: Chemodynamically Tagged Groups. II. An Extended Sample of Halo r-process-enhanced Stars

The Astrophysical Journal, 2023
Orbital characteristics based on Gaia Early Data Release 3 astrometric parameters are analyzed for ∼1700 r -process-enhanced (RPE; [Eu/Fe] > +0.3) metal-poor stars ([Fe/H] ≤ −0.8) compiled from the R -Process Alliance, the GALactic Archaeology with ...
Derek Shank, Timothy C. Beers, Vinicius M. Placco, Dmitrii Gudin, Thomas Catapano, Erika M. Holmbeck, Rana Ezzeddine, Ian U. Roederer, Charli M. Sakari, Anna Frebel, Terese T. Hansen   +10 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A Catalog of Distance Determinations for 5 Million Stars in LAMOST DR10

The Astronomical Journal
Using the distance estimation method outlined in J. L. Carlin et al., a Bayesian approach specifically tailored for LAMOST data, we estimated distances for 7,450,303 spectra from 5,394,174 unique stars in the LAMOST DR10 low-resolution data set.
Chengqun Yang, Xiang-Xiang Xue, Chao Liu, Hao Tian, Ling Zhu, Lan Zhang   +5 more
doaj   +1 more source