Results 61 to 70 of about 700 (297)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Detection of Multiple Phase Space Overdensities of GSE Stars by Orbit Integration

The Astrophysical Journal, 2023
In N -body simulations, nearly radial mergers can form shell-like overdensities in the sky position and phase space ( r − v _r ) due to the combination of dynamical friction and tidal stripping.
Wenbo Wu, Gang Zhao, Jiang Chang, Xiang-Xiang Xue, Yuqin Chen, Chengdong Li, Xianhao Ye, Chengqun Yang   +7 more
doaj   +1 more source

Small-scale stellar haloes: detecting low surface brightness features in the outskirts of Milky Way dwarf satellites [PDF]

, 2023
Jaclyn Jensen, Christian R. Hayes, Federico Sestito, Alan W. McConnachie, Fletcher Waller, Simon E. T. Smith, Julio F. Navarro, Kim A. Venn   +7 more
openalex   +1 more source

NanoMOF‐Based Multilevel Anti‐Counterfeiting by a Combination of Visible and Invisible Photoluminescence and Conductivity

Advanced Functional Materials, EarlyView.
This study presents novel anti‐counterfeiting tags with multilevel security features that utilize additional disguise features. They combine luminescent nanosized Ln‐MOFs with conductive polymers to multifunctional mixed‐matrix membranes and powder composites. The materials exhibit visible/NIR emission and matrix‐based conductivity even as black bodies.
Moritz Maxeiner, Ruben Maile, Murat Cuvalli, Andreas Wolf, Ayisha Komal, Robert Oestreich, Christoph Janiak, Karl Mandel, Alexander Knebel, Klaus Müller‐Buschbaum   +9 more
wiley   +1 more source

The Spectacular Tidal Tails of Globular Cluster M3 (NGC 5272)

The Astrophysical Journal, 2023
We provide a detailed analysis of the tidal tails of the globular cluster M3 (NGC 5272). We first discover clear extratidal structures with a slight S shape near the cluster. This inspires us to examine the existence of its long tidal tails. We highlight
Yong Yang, Jing-Kun Zhao, Xin-Zhe Tang, Xian-Hao Ye, Gang Zhao   +4 more
doaj   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Galactic-Seismology Substructures and Streams Hunter with LAMOST and Gaia. I. Methodology and Local Halo Results

The Astrophysical Journal
We present a novel, deep-learning-based method—dubbed Galactic-Seismology Substructures and Streams Hunter, or GS ^3 Hunter for short—to search for substructures and streams in stellar kinematics data.
Guan-Yu Wang, Hai-Feng Wang, Yang-Ping Luo, Yuan-Sen Ting, Thor Tepper-García, Joss Bland-Hawthorn, Jeffrey Carlin   +6 more
doaj   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Precise Asteroseismic Ages for the Helmi Streams

The Astrophysical Journal
The Helmi streams are remnants of a dwarf galaxy that was accreted by the Milky Way and whose stars now form a distinct kinematic and chemical substructure in the Galactic halo. Precisely age-dating these typically faint stars of extragalactic origin has
Christopher J. Lindsay, Marc Hon, J. M. Joel Ong, Rafael A. García, Dinil B. Palakkatharappil, Jie Yu, Tanda Li, Tomás Ruiz-Lara, Amina Helmi   +8 more
doaj   +1 more source

Orientations of Dark Matter Halos in FIRE-2 Milky Way–mass Galaxies

The Astrophysical Journal, 2023
The shape and orientation of dark matter (DM) halos are sensitive to the microphysics of the DM particles, yet in many mass models, the symmetry axes of the Milky Way’s DM halo are often assumed to be aligned with the symmetry axes of the stellar disk ...
Jay Baptista, Robyn Sanderson, Dan Huber, Andrew Wetzel, Omid Sameie, Michael Boylan-Kolchin, Jeremy Bailin, Philip F. Hopkins, Claude-André Faucher-Giguere, Sukanya Chakrabarti, Drona Vargya, Nondh Panithanpaisal, Arpit Arora, Emily Cunningham   +13 more
doaj   +1 more source