Results 61 to 70 of about 30,171 (324)

Chemical Abundances of the Outer Halo Stars in the Milky Way

, 2009
We present chemical abundances of 57 metal-poor stars that are likely constituents of the outer stellar halo in the Milky Way. Almost all of the sample stars have an orbit reaching a maximum vertical distance (Z_max) of >5 kpc above and below the ...
Aoki, W., Chiba, M., Ishigaki, M.
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

On the Corotation of Milky Way Satellites: LMC-mass Satellites Induce Apparent Motions in Outer Halo Tracers

The Astrophysical Journal
Understanding the physical mechanism behind the formation of a corotating thin plane of satellite galaxies, like the one observed around the Milky Way (MW), has been challenging.
Nicolás Garavito-Camargo, Adrian M. Price-Whelan, Jenna Samuel, Emily C. Cunningham, Ekta Patel, Andrew Wetzel, Kathryn V. Johnston, Arpit Arora, Robyn E. Sanderson, Lehman Garrison, Danny Horta   +10 more
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Deciphering the Kinematic Substructure of Local Dark Matter with LAMOST K Giants

The Astrophysical Journal
Numerical simulations indicate that correlations exist between the velocity distributions of stars and dark matter (DM). We study the local DM velocity distribution based on these correlations.
Hai Zhu, Rui Guo, Juntai Shen, Jianglai Liu, Chao Liu, Xiang-Xiang Xue, Lan Zhang, Shude Mao   +7 more
doaj   +1 more source

Characterizing the Chemistry of the Milky Way Stellar Halo: Detailed Chemical Analysis of a Metal-Poor Stellar Stream [PDF]

, 2010
We present the results of a detailed abundance analysis of one of the confirmed building blocks of the Milky Way stellar halo, a kinematically-coherent metal-poor stellar stream. We have obtained high resolution and high S/N spectra of 12 probable stream
Aoki, Arlandini, Beers, Bell, Belokurov, Belokurov, Belokurov, Biémont, Biémont, Biémont, Blackwell, Blackwell, Blackwell, Booth, Brown, Carlin, Carney, Carney, Castelli, Chiba, Chou, Chou, Christopher Sneden, Cohen, Cohen, Cohen, Cohen, Da Costa, Demarque, Den Hartog, Den Hartog, Farouqi, Frebel, Frebel, Frebel, Fuhr, Fulbright, Gallino, Geha, George W. Preston, Grevesse, Griffin, Grillmair, Grillmair, Grillmair, Han, Hannaford, Honda, Ian B. Thompson, Ian U. Roederer, Ivans, Ivarsson, Keeping, Kepley, Kirby, Klement, Kratz, Kurucz, Lai, Lawler, Lawler, Lawler, Lawler, Lawler, Lawler, Lawler, Lawler, Lee, Li, Lynden Bell, Majewski, Martinson, Martínez-Delgado, Milone, Morrison, Nahar, Newberg, Newberg, Nitz, Norris, Odenkirchen, Pickering, Pickering, Piotto, Preston, Roederer, Roederer, Roederer, Sadakane, Schatz, Shetrone, Skrutskie, Smith, Sneden, Sneden, Sneden, Sneden, Sobeck, Spite, Starkenburg, Stephen A. Shectman, Takeda, Vivas, Wallerstein, Whaling, Yanny, York, Zhang, Zucker   +108 more
core   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Detection of Multiple Phase Space Overdensities of GSE Stars by Orbit Integration

The Astrophysical Journal, 2023
In N -body simulations, nearly radial mergers can form shell-like overdensities in the sky position and phase space ( r − v _r ) due to the combination of dynamical friction and tidal stripping.
Wenbo Wu, Gang Zhao, Jiang Chang, Xiang-Xiang Xue, Yuqin Chen, Chengdong Li, Xianhao Ye, Chengqun Yang   +7 more
doaj   +1 more source

The Milky Way stellar halo out to 40 kpc: squashed, broken but smooth [PDF]

Monthly Notices of the Royal Astronomical Society, 2011
13 pages, 12 figures.
Alis J. Deason, Vasily Belokurov, Nick Evans   +2 more
openaire   +3 more sources