Results 61 to 70 of about 29,619 (304)

A mass-dependent density profile for dark matter haloes including the influence of galaxy formation [PDF]

, 2014
We introduce a mass-dependent density profile to describe the distribution of dark matter within galaxies, which takes into account the stellar-to-halo mass dependence of the response of dark matter to baryonic processes.
Aaron A. Dutton, Agertz, Alexander Knebe, Andrea V. Macciò, Arianna Di Cintio, Battaglia, Blumenthal, Brook, Brook, Brook, Bullock, Catena, Chabrier, Chris B. Brook, Cole, de Blok, de Blok, Deason, Del Popolo, Del Popolo, Di Cintio, Di Cintio, Duffy, Dutton, Dutton, Dutton, Dutton, El-Zant, Freyer, Gao, Gill, Gnedin, Goerdt, Goerdt, Governato, Governato, Greg S. Stinson, Guo, Hernquist, Jaffe, Kannan, Kannan, Katz, Kay, Kennicutt, Knollmann, Kuzio de Naray, Kuzio de Naray, Macciò, Macciò, Macciò, Martizzi, Mashchenko, Merritt, Mo, Moore, Moster, Muñoz-Cuartas, Navarro, Navarro, Navarro, Navarro, Nesti, Obreja, Oh, Peñarrubia, Pontzen, Pontzen, Power, Prada, Read, Read, Romano-Díaz, Salucci, Schmidt, Shen, Simon, Spergel, Springel, Stinson, Stinson, Stinson, Teyssier, Tonini, Wadsley, Walker, Zolotov   +86 more
core   +2 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

On the Corotation of Milky Way Satellites: LMC-mass Satellites Induce Apparent Motions in Outer Halo Tracers

The Astrophysical Journal
Understanding the physical mechanism behind the formation of a corotating thin plane of satellite galaxies, like the one observed around the Milky Way (MW), has been challenging.
Nicolás Garavito-Camargo, Adrian M. Price-Whelan, Jenna Samuel, Emily C. Cunningham, Ekta Patel, Andrew Wetzel, Kathryn V. Johnston, Arpit Arora, Robyn E. Sanderson, Lehman Garrison, Danny Horta   +10 more
doaj   +1 more source

The Spectacular Tidal Tails of Globular Cluster M3 (NGC 5272)

The Astrophysical Journal, 2023
We provide a detailed analysis of the tidal tails of the globular cluster M3 (NGC 5272). We first discover clear extratidal structures with a slight S shape near the cluster. This inspires us to examine the existence of its long tidal tails. We highlight
Yong Yang, Jing-Kun Zhao, Xin-Zhe Tang, Xian-Hao Ye, Gang Zhao   +4 more
doaj   +1 more source

Constraining the Milky Way halo potential with the GD-1 stellar stream [PDF]

Monthly Notices of the Royal Astronomical Society, 2019
Abstract We use ESA/Gaia astrometry together with SEGUE and LAMOST measurements of the GD-1 stellar stream to explore the improvement on the Galactic gravitational potential that these new data provide. Assuming a realistic universal model for the dark matter halo together with reasonable models of the baryonic components, we find that ...
Khyati Malhan, Khyati Malhan, Rodrigo A. Ibata   +2 more
openaire   +3 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

The PAndAS Field of Streams: stellar structures in the Milky Way halo toward Andromeda and Triangulum

, 2014
We reveal the highly structured nature of the Milky Way stellar halo within the footprint of the PAndAS photometric survey from blue main sequence and main sequence turn-off stars.
Babul, Arif, Bate, Nicholas F., Chapman, Scott C., Collins, Michelle L. M., Conn, Anthony R., Crnojević, Denija, Fardal, Mark A., Ferguson, Annette M. N., Ibata, Rodrigo A., Irwin, Michael J., Lewis, Geraint F., Mackey, A. Dougal, Martin, Nicolas F., McConnachie, Alan W., Navarro, Julio F., Peñarrubia, Jorge, Rich, R. Michael, Tanvir, Nial T., Valls-Gabaud, David   +18 more
core   +2 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Orientations of Dark Matter Halos in FIRE-2 Milky Way–mass Galaxies

The Astrophysical Journal, 2023
The shape and orientation of dark matter (DM) halos are sensitive to the microphysics of the DM particles, yet in many mass models, the symmetry axes of the Milky Way’s DM halo are often assumed to be aligned with the symmetry axes of the stellar disk ...
Jay Baptista, Robyn Sanderson, Dan Huber, Andrew Wetzel, Omid Sameie, Michael Boylan-Kolchin, Jeremy Bailin, Philip F. Hopkins, Claude-André Faucher-Giguere, Sukanya Chakrabarti, Drona Vargya, Nondh Panithanpaisal, Arpit Arora, Emily Cunningham   +13 more
doaj   +1 more source

The masses and metallicities of stellar haloes reflect galactic merger histories

, 2017
There is increasing observational and theoretical evidence for a correlation between the metallicity and the mass of the stellar halo for galaxies with Milky Way-like stellar masses.
Bell, Eric, D'Souza, Richard
core   +1 more source