Results 161 to 170 of about 52,000 (299)
Macrophage HM13/SPP Enhances Foamy Macrophage Formation and Atherogenesis
Advanced Science, EarlyView.Previous research suggests that AIP may prevent atherogenic foamy macrophage formation. This study reveals that AIP, via its chaperone interaction with AHR, inhibits p38‐c‐JUN‐mediated transactivation of HM13, which encodes the ERAD protease HM13/SPP. HM13/SPP promotes foamy macrophage formation in addition to atherogenesis and plaque foamy macrophage ...
Yu Cao +15 more
wiley +1 more source
Under Sundanese eyes; Raden Ajoe Abdoerachman’s journey to Europe
Wacana: Journal of the Humanities of IndonesiaThis article examines the travel account written by Raden Ajoe Abdoerachman, the wife of a senior native official, the Regent of Meester Cornelis (Jatinegara), Raden Aria Abdoerachman, who, with his family, was sent at the expense of the colonial ...
Atep Kurnia
doaj +1 more source
Advanced Science, EarlyView.This study indicates that Serpine2 plays a pivotal role in hair cell (HC) regeneration from Lgr5+ progenitors in the neonatal mouse cochlea. Conditional overexpression of Serpine2 in cochlear Lgr5+ progenitors results in a significantly increased number of ectopic HCs, particularly ectopic inner HCs, and these HCs are likely derived from Lgr5 ...
Hairong Xiao +14 more
wiley +1 more source
Gayana, 2009 Soon after his return from the Malay Archipelago, Alfred Russel Wallace published one of his most signifcant papers. The paper used butterfies of the family Papilionidae as a model system for testing evolutionary hypotheses, and included a revision of ...
James Mallet
doaj
Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications
Advanced Science, EarlyView.HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang +5 more
wiley +1 more source
PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
Advanced Science, EarlyView.Pancreatic ductal adenocarcinoma features abundant stromal components that hinder therapy efficacy. Single‐cell RNA sequencing analysis combined with experiments identified PPY, a gastrointestinal hormone, as a novel inducer of immunosuppressive iCAFs. Mechanistic studies revealed that PPY activates the non‐canonical NF‐κB pathway via EGFR.
Mengdie Cao +14 more
wiley +1 more source
On Diaposematism, with reference to some limitations of the Müllerian Hypothesis of Mimicry
, 1908 Guy A. K. Marshall
openalex +2 more sources
Advanced Science, EarlyView.Leukocytes sense mechanical cues provided by surrounding cells to regulate motility. Replicating the confining pressures applied by soft, elastic tissues in vitro is challenging. Here, the use of liquid‐liquid interfaces is introduced to model forces exerted by surrounding cells. Confining pressures are tunable by controlling interfacial curvature, and
Jonathan H. Schrope +13 more
wiley +1 more source