Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao +14 more
wiley +1 more source
Could vector-derived cadherin mimicry contribute to pemphigus vulgaris? An immunogenetic and <i>in silico</i> study involving HLA-DRB104:02 and 14:01. [PDF]
Toraman B +4 more
europepmc +1 more source
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao +12 more
wiley +1 more source
Covert underwater communication through cepstrum modulation mimicking Pseudorca crassidens whistles using machine learning. [PDF]
Bilal M +7 more
europepmc +1 more source
Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang +9 more
wiley +1 more source
Commentary: Decoding the charitable brain: empathy, perspective taking, and attention shifts differentially predict altruistic giving [PDF]
ERA, VANESSA +2 more
core +2 more sources
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling +17 more
wiley +1 more source
Structural and Functional Mise en Abyme
Bérangère Avalle +5 more
doaj +1 more source
RNA methyltransferase NSUN2 enhances vasculogenic mimicry and malignant progression of cervical cancer through upregulation of MMP-9. [PDF]
Luo J +8 more
europepmc +1 more source

