Results 41 to 50 of about 24,541 (307)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

MULSOPS: Multivariate Optimized Pit Shells Simulator for Tactical Mine Planning

, 1998
Production planning, scheduling and allocation of resources in large-scale surface mining operations present a great challenge to mine planning engineers.
Asa, E., Szymanski, J., Frimpong, Samuel
core   +1 more source

A new mine planning tool for sublevel caving mines [PDF]

Proceedings of the Second International Symposium on Block and Sublevel Caving, 2010
This paper presents an overview of a new application specifically developed for the planning and scheduling of sublevel caving (SLC) projects and operations. Conventional mine planning software tools are not well suited to the evaluation of this type of deposit due to their inability to model the dilution behaviour.
Daniel Villa, Tony Diering
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Distribution of Operating Costs Along the Value Chain of an Open-Pit Copper Mine

Applied Sciences
This study analyzes the distribution of operating costs along the value chain of an open-pit copper mine with a focus on key operational units or operations such as drilling, blasting, loading, hauling, stockpiling, blending, crushing, milling, and ...
Hervé Losaladjome Mboyo, Bingjie Huo, François K. Mulenga, Pieride Mabe Fogang, Jimmy Kalenga Kaunde Kasongo   +4 more
doaj   +1 more source

Dispatch Optimization Model for Haulage Equipment between Stopes Based on Mine Short-Term Resource Planning

Metals, 2021
The working environment of underground mines is complicated, making it difficult to construct an underground mine production plan. In response to the requirements for the preparation of a short-term production plan for underground mines, an optimization ...
Ning Li, Shuzhao Feng, Haiwang Ye, Qizhou Wang, Mingtao Jia, Liguan Wang, Shugang Zhao, Dongfang Chen   +7 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Comparison between the application of the conventional mine planning and of the direct block scheduling on an open pit mine Project

REM: International Engineering Journal
Historically, since the 60's, traditional mine planning consists of several distinct stages: 1) Definition of the ultimate pit - the portion of the blocks that results in the greatest total value; 2) Pushback selection - based on the generation of nested
Pedro Henrique Alves Campos, Ivo Eyer Cabral, Carlos Enrique Arroyo Ortiz, Nelson Morales   +3 more
doaj   +1 more source

Review of GIS-Based Applications for Mining: Planning, Operation, and Environmental Management

Applied Sciences, 2020
In this study, geographic information system (GIS)-based methods and applications utilized for mine development were reviewed. Three types of GIS-based studies, namely studies on mine planning, operation, and environmental management, were examined to ...
Yosoon Choi, Jieun Baek, Sebeom Park
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source