Results 61 to 70 of about 24,541 (307)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Quantifying dilution caused by execution efficiency
REM: International Engineering JournalIn open pit mining, dilution is not always a factor systematically analyzed and calculated. Often it is only an adjusted number, for example, calculated or even empirically determined for a certain operational condition perpetuating along time in the ...
Taís Renata Câmara +1 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2013 This project investigates the feasibility of combining overburden (OB) produced from an open cut brown coal mine, rejected wood chip waste from a Kraft Paper Mill (KMR), and industrially derived compost.
Panther, Barbara +5 more
core +1 more source
MiningFires in underground mines pose significant risks to worker safety. In this study, a digital twin of an underground mine was created, and the heat, gas distribution, and airflow dynamics were investigated during and after the fire using computational ...
Cemalettin Okay Aksoy +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Stochastic optimization of strategic mine planning of a hypothetical copper deposit through a parametrizable algorithm [PDF]
, 2016 To perform a surface mine planning it is necessary to start from an initial evaluation of the mineral resource. The open pit schedule evaluation is a key step in the process of planning the extraction activities of a mining company.
Pareja Zapata, José Mario
core
International Journal of Occupational and Environment Safety, 2019 Mining industry importance stems from the fact that it forms the basis of all materials used by humankind, including the agro-industrial sector, where products such as phosphates are behind a significant part of all modern agriculture.
Rania Rebbah +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source