A rare case of apparent mineralocorticoid excess induced by chronic liquorice ingestion [PDF]
Endocrinology, Diabetes & Metabolism Case ReportsApparent mineralocorticoid excess (AME) syndrome is a rare condition caused by the inhibition of the renal enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). The most common acquired cause is chronic liquorice ingestion.
Aparajita Roy, Kieran Mullins
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Regulation of Klotho Production by Mineralocorticoid Receptor Signaling in Renal Cell Lines [PDF]
BiomoleculesThrough the mineralocorticoid receptor, aldosterone controls extracellular volume and arterial blood pressure by stimulating Na+ absorption and K+ secretion in epithelial cells of the kidney, colon, and several glands.
Elena Kohm +2 more
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Mineralocorticoid hypertension
Indian Journal of Endocrinology and Metabolism, 2011 Hypertension affects about 10 - 25% of the population and is an important risk factor for cardiovascular and renal disease. The renin-angiotensin system is frequently implicated in the pathophysiology of hypertension, be it primary or secondary.
Vishal Gupta
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Effect of Mineralocorticoid receptor antagonism (MRA) on aldosterone-interleukin 6 axis in heart failure; second opinion. A case-control study [PDF]
The Egyptian Journal of Internal MedicineBackground In cases of heart failure characterized by reduced ejection fraction (HFrEF), heightened levels of aldosterone negatively impact the progression of heart failure.
H. ElSawi, S. Zidan, A. Elborolosy
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Bilateral Adrenal Masses with Different Aetiologies Presenting as Addisonian Crisis with Acute Kidney Injury: A Case Series [PDF]
Journal of Clinical and Diagnostic Research, 2023 An Addisonian Crisis (AC) is an endocrinological emergency associated with high mortality, resulting from an acute deficit of hormones from the adrenal glands.
Mohini +4 more
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Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor [PDF]
Endocrinology and Metabolism, 2021 Background Despite clinical evidence indicating poor muscle health in subjects with primary aldosteronism (PA), it is still unclear whether the role of aldosterone in muscle metabolism is direct or mediated indirectly via factors, such as electrolyte ...
Jin Young Lee +5 more
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case of liquorice-infused marijuana causing syndrome of apparent mineralocorticoid excess
European Journal of Case Reports in Internal Medicine, 2023 Marijuana has long been used both for recreational and medicinal purposes. Most of the available forms of marijuana contain additives such as liquorice to enhance its flavour. Liquorice increases the amounts of cortisol in the body and produces metabolic
Asnia Latif +2 more
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Diabetes and Excess Aldosterone Promote Heart Failure With Preserved Ejection Fraction
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background The pathobiology of heart failure with preserved ejection fraction (HFpEF) is still poorly understood, and effective therapies remain limited.
Bence Hegyi +9 more
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Heterogeneous natural history of Addison’s disease: mineralocorticoid deficiency may predominate
Endocrine Connections, 2022 Autoimmune Addison’s disease (AAD) is defined as primary adrenal insufficiency due to immune-mediated destruction of the adrenal cortex. This destruction of steroid-producing cells has historically been thought of as an irreversible process, with linear ...
Sophie Howarth +3 more
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Journal of Veterinary Internal Medicine, 2023 Background Primary hypoadrenocorticism (PH) is rare in cats and knowledge about treatment is sparse. Objective To describe cats with PH with a focus on long‐term treatment. Animals Eleven cats with naturally occurring PH.
Nadja S. Sieber‐Ruckstuhl +8 more
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