Regulation of Klotho Production by Mineralocorticoid Receptor Signaling in Renal Cell Lines [PDF]
BiomoleculesThrough the mineralocorticoid receptor, aldosterone controls extracellular volume and arterial blood pressure by stimulating Na+ absorption and K+ secretion in epithelial cells of the kidney, colon, and several glands.
Elena Kohm +2 more
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The Journal of Clinical Investigation, 2023 Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our study, we used single-cell expression and chromatin accessibility tools to characterize the mineralocorticoid target genes and cell types.
Amin Abedini +14 more
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Does Mineralocorticoid Receptor Antagonism Prevent Calcineurin Inhibitor-Induced Nephrotoxicity? [PDF]
Frontiers in Medicine, 2017 Calcineurin inhibitors have markedly reduced acute rejection rates in renal transplantation, thus significantly improved short-term outcome. The beneficial effects are, however, tampered by acute and chronic nephrotoxicity leading to interstitial ...
Line Aas Mortensen +5 more
doaj +2 more sources
Nature Communications, 2019 Choroidal neovascularization (CNV) is a major cause of visual impairment in patients suffering from wet age-related macular degeneration (AMD), particularly when refractory to intraocular anti-VEGF injections.
Min Zhao, Irmela Mantel, Andrea Prunotto
exaly +2 more sources
A rare case of apparent mineralocorticoid excess induced by chronic liquorice ingestion [PDF]
Endocrinology, Diabetes & Metabolism Case ReportsApparent mineralocorticoid excess (AME) syndrome is a rare condition caused by the inhibition of the renal enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). The most common acquired cause is chronic liquorice ingestion.
Aparajita Roy, Kieran Mullins
doaj +2 more sources
Obesity, aldosterone excess, and mineralocorticoid receptor activation: Parallel or intersected circumstances? [PDF]
The Journal of Clinical HypertensionThe obesity pandemic, with its associated comorbidities of hypertension and diabetes, constitutes a global public health issue. Importantly, there is an increasing prevalence of aldosterone excess related to obesity and resultant poor health outcomes ...
Houry Puzantian +2 more
doaj +2 more sources
Bilateral Adrenal Masses with Different Aetiologies Presenting as Addisonian Crisis with Acute Kidney Injury: A Case Series [PDF]
Journal of Clinical and Diagnostic Research, 2023 An Addisonian Crisis (AC) is an endocrinological emergency associated with high mortality, resulting from an acute deficit of hormones from the adrenal glands.
Mohini +4 more
doaj +1 more source
Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor [PDF]
Endocrinology and Metabolism, 2021 Background Despite clinical evidence indicating poor muscle health in subjects with primary aldosteronism (PA), it is still unclear whether the role of aldosterone in muscle metabolism is direct or mediated indirectly via factors, such as electrolyte ...
Jin Young Lee +5 more
doaj +1 more source
case of liquorice-infused marijuana causing syndrome of apparent mineralocorticoid excess
European Journal of Case Reports in Internal Medicine, 2023 Marijuana has long been used both for recreational and medicinal purposes. Most of the available forms of marijuana contain additives such as liquorice to enhance its flavour. Liquorice increases the amounts of cortisol in the body and produces metabolic
Asnia Latif +2 more
doaj +1 more source
Diabetes and Excess Aldosterone Promote Heart Failure With Preserved Ejection Fraction
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background The pathobiology of heart failure with preserved ejection fraction (HFpEF) is still poorly understood, and effective therapies remain limited.
Bence Hegyi +9 more
doaj +1 more source