Results 181 to 190 of about 26,548 (293)

The mineralocorticoid receptor antagonist finerenone enhances cardiovascular recovery upon food intake normalization in obese mice. [PDF]

Cardiovasc Diabetol
Manon MF, Marie PD, Benjamin B, Coralie F, Linghui K, Amhrae ND, Lionel N, Saïda M, Sylvanie R, Anaïs D, Vincent R, Bruno F, Frédéric J, Sheerazed B, Paul M, Antoine OP.   +15 more
europepmc   +1 more source

Gut Dysbiosis as a Shared Mechanism in Obesity and Hypertension: Exploring a Promising Therapeutic Avenue

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This review synthesises current knowledge on gut microbiome involvement in obesity and hypertension, evaluates microbiome‐based therapeutic strategies, and identifies critical research gaps to guide future investigations aimed at mitigating the dual pandemics.
Andrej Belančić, Almir Fajkić, Yusuf Ziya Sener, Ana Jelaković, Lejla Alić, Elvira Meni Maria Gkrinia, Donatella Verbanac, Bojan Jelaković   +7 more
wiley   +1 more source

Pharmacology and Therapeutic Potential of Finerenone: A Novel Third-Generation Nonsteroidal Mineralocorticoid Receptor Antagonist. [PDF]

Cureus
Ramadan MM, Alajmi S, Aldouseri J, Alajmi M, Tello EA, Mahdi AO, Aladwani AJ, Alayyaf AE, Mahdi O, Elmahal M.   +9 more
europepmc   +1 more source

Cardiovascular and Renal Outcomes with Finerenone, a Selective Mineralocorticoid Receptor Antagonist. [PDF]

Cardiol Ther, 2022
Palanisamy S, Funes Hernandez M, Chang TI, Mahaffey KW.   +3 more
europepmc   +1 more source

Fasting and Caloric Restriction Activate an ADIOL‐NHR‐91‐Kynurenine Pathway Signaling Axis to Promote Healthspan

Aging Cell, Volume 25, Issue 5, May 2026.
The steroid hormone ADIOL emerges as a key mediator of fasting–and caloric restriction–induced healthspan benefits in C. elegans. These regimens activate ADIOL production, which acts through the estrogen receptor β homolog NHR‐91 to reduce neural kynurenic acid levels and enhance healthspan independently of lifespan. ADIOL supplementation, even late in
Ana Guijarro‐Hernández, Shinja Yoo, George A. Lemieux, Sena Komatsu, Abdullah Q. Latiff, Rishika R. Patil, Kaveh Ashrafi   +6 more
wiley   +1 more source

Observation of the therapeutic effect of finerenone, a novel non-steroidal mineralocorticoid receptor antagonist, in patients with non-diabetic CKD. [PDF]

Ren Fail
Li F, Han J, Zhang W, Lv J, Wang Z, Li H, Jin L, Feng J, Lu W, Sun J.   +9 more
europepmc   +1 more source

Serum potassium level and mineralocorticoid receptor antagonist dose in a large cohort of chronic heart failure patients. [PDF]

ESC Heart Fail, 2023
Clephas PRD, Radhoe SP, Linssen GCM, Langerveld J, Plomp J, Smits JPP, Nagelsmit MJ, Rocca HB, Brugts JJ.   +8 more
europepmc   +1 more source

Low‐Salt Diet Induces Claudin‐3 Expression and Drives Adaptive Changes in Collecting Duct of Claudin‐3‐Deficient Mice

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Aim Renal sodium reabsorption occurs through both transcellular and paracellular pathways. Tight junction proteins play a key role in mediating paracellular transport. The collecting duct is critical for the fine tuning of sodium balance and is highly responsive to changes in dietary salt intake.
Ali Sassi, Alexandra Chassot, Sara Jellali, Nicolas Liaudet, Ana Polat, Felix Baier, Deborah Stroka, Mikio Furuse, Eric Feraille   +8 more
wiley   +1 more source

Association Between Mineralocorticoid Receptor Antagonist Use With Worsening Renal Function and Prognosis in Patients With Acute Heart Failure. [PDF]

J Am Heart Assoc
Fujimoto Y, Shiraishi Y, Nogi K, Kohsaka S, Kohno T, Kitamura M, Nagatomo Y, Ueda T, Nogi M, Ishihara S, Nakada Y, Kawakami R, Kitai T, Oishi S, Akiyama E, Suzuki S, Yamamoto M, Kida K, Okumura T, Yoshikawa T, Saito Y, Matsue Y.   +21 more
europepmc   +1 more source

The Effect of Potassium Canrenoate (Mineralocorticoid Receptor Antagonist) on the Markers of Inflammation in the Treatment of COVID-19 Pneumonia and Fibrosis-A Secondary Analysis of Randomized Placebo-Controlled Clinical Trial. [PDF]

Int J Mol Sci, 2023
Karolak I, Hrynkiewicz R, Niedźwiedzka-Rystwej P, Lechowicz K, Sieńko J, Szylińska A, Dabrowski W, Kotfis K.   +7 more
europepmc   +1 more source