Experimental Physiology, EarlyView.Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores +4 more
wiley +1 more source
Sodium-Glucose Co-Transporter 2 Inhibitors and Hyperkalemia-Related Discontinuation of Renin-Angiotensin-Aldosterone System Inhibitors During Mineralocorticoid Receptor Antagonist Therapy: A Real-World Cohort Study. [PDF]
Pharmacy (Basel)Almalki AH +6 more
europepmc +1 more source
Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells
The Journal of Physiology, EarlyView.Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski +3 more
wiley +1 more source
The mineralocorticoid receptor antagonist finerenone enhances cardiovascular recovery upon food intake normalization in obese mice. [PDF]
Cardiovasc DiabetolMonmirel-Fauconnier M +15 more
europepmc +1 more source
The Nonsteroidal Mineralocorticoid-Receptor-Antagonist Finerenone in Cardiorenal Medicine: A State-of-the-Art Review of the Literature. [PDF]
Am J Hypertens, 2023 Georgianos PI, Agarwal R.
europepmc +1 more source
On the importance of including both sexes in animal studies – insights from home‐cage monitoring
Biological Reviews, Volume 101, Issue 5, Page 2408-2426, October 2026.ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater +12 more
wiley +1 more source
Targeted proteomic analyses during combined angiotensin-converting enzyme inhibitor and mineralocorticoid receptor antagonist administration (CARDALIS®) in healthy dogs. [PDF]
J Vet Intern MedWard JL +9 more
europepmc +1 more source
SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic +4 more
wiley +1 more source
Pharmacology and Therapeutic Potential of Finerenone: A Novel Third-Generation Nonsteroidal Mineralocorticoid Receptor Antagonist. [PDF]
CureusRamadan MM +9 more
europepmc +1 more source
MedComm, Volume 7, Issue 10, October 2026.In a nationwide heart failure cohort, cardiovascular–kidney–metabolic (CKM) multimorbidity was common in Chinese hospitalized heart failure (HF) patients and associated with poor prognosis. Higher CKM burden and combinations identified high‐risk patients.
Xiang Wang +15 more
wiley +1 more source