Results 221 to 230 of about 1,320,527 (284)

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, Volume 105, Issue 3, Page 271-284, September 2026.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source

Prenatal exposure to the mineralocorticoid receptor antagonist spironolactone disrupts hippocampal area CA2 connectivity and alters behavior in mice. [PDF]

Neuropsychopharmacology
Jones SM, Sleiman SJ, McCann KE, Jarmusch AK, Alexander GM, Dudek SM.   +5 more
europepmc   +1 more source

Impact of Simultaneous Initiation of Finerenone and Empagliflozin on Albuminuria Irrespective of Baseline HbA1c Levels: A Participant‐Level Exploratory Analysis of the Randomised CONFIDENCE Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 7964-7973, September 2026.
ABSTRACT Aims This prespecified analysis evaluated whether the safety and efficacy of finerenone and a sodium–glucose cotransporter 2 inhibitor (SGLT2i) combination vary by baseline glycated haemoglobin (HbA1c). Materials and Methods Adults with type 2 diabetes and a urinary albumin‐to‐creatinine ratio (UACR) of 100 − < 5000 mg/g, estimated glomerular ...
Janet B. McGill, Jennifer B. Green, Hiddo J. L. Heerspink, Johannes F. E. Mann, Amy K. Mottl, Julio Rosenstock, Peter Rossing, Muthiah Vaduganathan, Masaomi Nangaku, Meike Brinker, Charlie Scott, Katja Rohwedder, Li Li, Na Li, Margarida Seco, Rajiv Agarwal   +15 more
wiley   +1 more source

Pharmacokinetics of the Novel Nonsteroidal Mineralocorticoid Receptor Antagonist Ocedurenone (KBP-5074) in Individuals with Moderate Hepatic Impairment. [PDF]

Eur J Drug Metab Pharmacokinet
McCabe J, Zhang J, Yang F, Benn V.
europepmc   +1 more source

Left Atrial Reservoir Strain and Heart Failure Rehospitalization Burden in Acute Heart Failure With Atrial Fibrillation

Echocardiography, Volume 43, Issue 9, September 2026.
This graphical abstract summarizes 716 patients with acute heart failure and atrial fibrillation. The left atrial diameter analysis included 691 patients (189 rehospitalization‐first, 118 death‐first, 384 censored); volume index and reservoir strain were available in a 320‐patient single‐center subgroup.
Jumpei Yamamoto, Keijiro Nakamura, Hiromasa Hayama, Yoshinari Enomoto, Masaya Yamamoto, Hidehiko Hara, Hisao Hara, Yukio Hiroi   +7 more
wiley   +1 more source

Mineralocorticoid receptor antagonist treatment in patients with renal insufficiency and the associated risk of hyperkalemia and death. [PDF]

J Hypertens
Hedlund Møller S, Haagensen Kofod D, Schou M, Torp-Pedersen C, Gislason G, Carlson N, Lindhardt M.   +6 more
europepmc   +1 more source

Cardiac Structure and Function and Pulmonary Congestion Across New York Heart Association Classes in Patients With Acute Heart Failure

Echocardiography, Volume 43, Issue 9, September 2026.
Higher NYHA class was associated with greater comorbidity burden and worse cardiac structure and function at baseline in patients with acute heart failure. Despite these differences, echocardiographic abnormalities improved at follow‐up, and 180‐day mortality or readmission did not differ significantly across NYHA classes.
Ali Hikmat Al‐Rubai, Filip Soeskov Davidovski, Caroline Espersen, Anton Stanchev, Laura Maria Adam, Ayat Khoraizat, Kristoffer Grundtvig Skaarup, Maria Dons, Jacob Christensen, Emil Durukan, Ema Rastoder, Morten Sengeløv, Katrine Feldballe Bernholm, Lisa Steen Duus, Caroline Løkke Bjerregaard, Zahra Juma, Mats Christian Højbjerg Lassen, Anne Marie Reimer Jensen, Adam Femerling Langhoff, Peter Godsk Jørgensen, Manan Pareek, Emil Wolsk, Morten Schou, Tor Biering‐Sørensen   +23 more
wiley   +1 more source

Cardiovascular and Renal Outcomes with Ertugliflozin by Baseline Use of Renin-Angiotensin-Aldosterone System Inhibitors or Diuretics, Including Mineralocorticoid Receptor Antagonist: Analyses from the VERTIS CV Trial. [PDF]

Kidney Dis (Basel)
Cherney DZI, Frederich R, Pratley RE, Cosentino F, Dagogo-Jack S, Pong A, Gantz I, Cater NB, Mancuso JP, Masiukiewicz U, Cannon CP.   +10 more
europepmc   +1 more source

Withholding Oral Anticoagulation at Discharge and Post‐Discharge Stroke and Bleeding Vulnerability in a Predominantly Older Cohort Hospitalized With Acute Heart Failure and Atrial Fibrillation

Geriatrics &Gerontology International, Volume 26, Issue 9, September 2026.
Among 560 predominantly older patients discharged after acute heart failure with atrial fibrillation, withholding oral anticoagulation was associated with higher ischemic stroke and did not indicate lower bleeding risk. Bleeding risk was significantly higher among patients aged 80 years or older.
Jumpei Yamamoto, Keijiro Nakamura, Hiromasa Hayama, Yoshinari Enomoto, Masaya Yamamoto, Hidehiko Hara, Hisao Hara, Yukio Hiroi   +7 more
wiley   +1 more source

Comparative Efficacy of Aldosterone‐Related Sodium‐Retention Pathway Therapies for Resistant Hypertension: A Drug‐Level Network Meta‐Analysis of Randomized Controlled Trials

The Journal of Clinical Hypertension, Volume 28, Issue 9, September 2026.
ABSTRACT Mineralocorticoid receptor antagonists (MRAs), aldosterone synthase inhibitors (ASIs), and epithelial sodium channel (ENaC) blockade target different levels of the aldosterone‐related sodium‐retention pathway in resistant hypertension (RH), but the comparative efficacy of individual agents remains uncertain.
Yi‐Liang Tsou, Yu‐Hung Wang, Yi‐Siou Lin, Chia‐Liang Chen   +3 more
wiley   +1 more source