Results 221 to 230 of about 26,548 (293)

Macrophage Cluster of Differentiation 163 promotes post‐infarction cardiac repair and preserves left ventricular function via osteopontin

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
• Circulating soluble CD163 is elevated in ischaemic cardiomyopathy and correlates with systolic dysfunction severity and ventricular dilation. • Macrophage CD163 protects against post‐infarction systolic dysfunction and left ventricular dilation in mice. • Loss of CD163 decreases macrophage osteopontin expression.
Jingyu Chen, Linjian Chen, Wei Huang, Gang Wang, Lin Wang, Wanchun Mei, Wei Ni, Yang Liu, Licheng Ding, Xiaofeng Ge, Zhaokai Li, Jing Yu, Shufen Huang, Jiayi Lin, Yifan Chen, Binni Cai, Peng Zhang, Cuilian Dai, Binbin Liu   +18 more
wiley   +1 more source

Protective Effects of Agrimonia pilosa Ledeb. In Myocardial Fibrosis: Inhibition of Mitophagy Mediated by the FOXO Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Agrimonia pilosa Ledeb. has the effect of repairing myocardial injury, reducing myocardial hypertrophy, and improving MF. Mechanistically, it acts by inhibiting mitophagy mediated by the FOXO signaling pathway, as validated via network pharmacology, in vitro, and in vivo experiments. ABSTRACT Agrimonia pilosa Ledeb.
Jian Chen, Zhixiang Wei, Jiaqi An, Dantong Li, Ying Gu, Yixin Zhang, Muqing Zhang   +6 more
wiley   +1 more source

Female Sex as a Major Risk Factor for Dabigatran‐Induced Esophagitis in Atrial Fibrillation Ablation

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
Dabigatran‐induced esophagitis occurred in 18.7% of patients undergoing atrial fibrillation ablation. Female sex was identified as an independent predictor of this complication, highlighting the need for careful periprocedural management and preventive strategies in women.
Daiki Saito, Hidehira Fukaya, Takuya Wada, Jun Oikawa, Sho Ogiso, Yusuke Murayama, Tetsuro Sato, Gen Matsuura, Yuki Arakawa, Shuhei Kobayashi, Hironori Nakamura, Naruya Ishizue, Jun Kishihara, Shinichi Niwano, Satoshi Tanabe, Chika Kusano, Junya Ako   +16 more
wiley   +1 more source

Beyond “One‐Size‐Fits‐All”: Deconstructing the Hormonal Determinants of Sodium Sensitivity in Treated Hypertension

The Journal of Clinical Hypertension, Volume 28, Issue 5, May 2026.
Dae‐Hee Kim
wiley   +1 more source

Predictors and Outcomes of Pharmacological and Electrical Cardioversion for Atrial Fibrillation and Flutter in an Indian Emergency Department: A Retrospective Study

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
In a real‐world emergency department study of atrial fibrillation and flutter, cardioversion restored sinus rhythm in 68% of patients. Electrical cardioversion achieved the highest success, while pharmacological and mixed strategies predicted failure. Complications were infrequent but clinically significant.
Abid M. Sadiq, Bhavana Keerthiparti, Kapil Kumawat, Deepak Padmanabhan   +3 more
wiley   +1 more source

Prenatal exposure to the mineralocorticoid receptor antagonist spironolactone disrupts hippocampal area CA2 connectivity and alters behavior in mice. [PDF]

Neuropsychopharmacology
Jones SM, Sleiman SJ, McCann KE, Jarmusch AK, Alexander GM, Dudek SM.   +5 more
europepmc   +1 more source

Sex‐Specific Gene Expression Ontogeny During Gonadal Development in Post‐Metamorphic Xenopus tropicalis

Molecular Reproduction and Development, Volume 93, Issue 4, April 2026.
Post‐metamorphic gonadal development in Xenopus tropicalis was analyzed through integrated morphometric, histological, and transcriptional approaches. Males showed upregulation of cyp17, amh, and amhr2, whereas females exhibited an increased aldh1a2 and ddx4.
Daniele Marini, Mauricio Roza, Cecilia Berg, Vanessa Brouard   +3 more
wiley   +1 more source

Pharmacokinetics of the Novel Nonsteroidal Mineralocorticoid Receptor Antagonist Ocedurenone (KBP-5074) in Individuals with Moderate Hepatic Impairment. [PDF]

Eur J Drug Metab Pharmacokinet
McCabe J, Zhang J, Yang F, Benn V.
europepmc   +1 more source

A Circadian Trough in Glucocorticoid Signaling Is Essential for Bone Health in Mice

Aging Cell, Volume 25, Issue 4, April 2026.
Flattening the circadian rhythm of endogenous glucocorticoids induces osteoporosis in mice. We demonstrate that reinstating a trough in glucocorticoid receptor signaling stimulates bone formation and suffices to prevent osteoporosis. Reinstating the trough at its natural time of day is needed for full protection.
Annelies E. Smit, Kaiming Yue, Sander Kooijman, Salwa Afkir, Maaike Schilperoort, Marijke Koedam, Bram C. J. van der Eerden, Jan Kroon, Onno C. Meijer, Elizabeth M. Winter   +9 more
wiley   +1 more source

Mineralocorticoid receptor antagonist treatment in patients with renal insufficiency and the associated risk of hyperkalemia and death. [PDF]

J Hypertens
Hedlund Møller S, Haagensen Kofod D, Schou M, Torp-Pedersen C, Gislason G, Carlson N, Lindhardt M.   +6 more
europepmc   +1 more source