Mineralocorticoid receptors in the pathophysiology of vascular inflammation and atherosclerosis. [PDF]
Frontiers in Endocrinology, 2015 Atherosclerosis is a chronic inflammatory disease of the vasculature that causes significant morbidity and mortality from myocardial infarction, stroke, peripheral vascular disease, and heart failure.
Mary Elizabeth Moss +3 more
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Novel role for mineralocorticoid receptors in control of a neuronal phenotype. [PDF]
Mol Psychiatry, 2021 Mineralocorticoid receptors (MRs) in the brain play a role in learning and memory, neuronal differentiation, and regulation of the stress response. Within the hippocampus, the highest expression of MRs is in area CA2.
McCann KE +8 more
europepmc +2 more sources
Glucocorticoid and Mineralocorticoid Receptors in the Brain: A Transcriptional Perspective. [PDF]
J Endocr Soc, 2019 Adrenal glucocorticoid hormones are crucial for maintenance of homeostasis and adaptation to stress. They act via the mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs)—members of the family of nuclear receptors. MRs and GRs can mediate
Koning ACAM +3 more
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Therapeutic targeting of mineralocorticoid receptors in pulmonary hypertension: Insights from basic research [PDF]
Frontiers in Cardiovascular Medicine, 2023 Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling and associated with adverse outcomes. In patients with PH, plasma aldosterone levels are elevated, suggesting that aldosterone and its receptor, the mineralocorticoid receptor (
Argen Mamazhakypov +2 more
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Aldosterone and Mineralocorticoid Receptors-Physiology and Pathophysiology. [PDF]
Int J Mol Sci, 2017 Aldosterone is a uniquely terrestrial hormone, first appearing in lungfish, which have both gills and lungs. Mineralocorticoid receptors (MRs), on the other hand, evolved much earlier, and are found in cartilaginous and bony fish, presumptive ligand ...
Funder JW.
europepmc +2 more sources
NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus. [PDF]
Cells, 2019 Aldosterone excess aggravates endothelial dysfunction in diabetes and hypertension by promoting the increased generation of reactive oxygen species, inflammation, and insulin resistance. Aldosterone activates the molecular platform inflammasome in immune
Ferreira NS +10 more
europepmc +2 more sources
Cardiac response to chronic restraint stress involves mineralocorticoid receptors in male Sprague–Dawley rats [PDF]
Physiological ReportsIn the present study, we aimed at elucidating whether exposure to chronic stress affects the expression of cardiac mineralocorticoid receptors (MRs), whether it influences cardiac structure and function, and whether MRs blockade attenuates the stress ...
D. Sztechman +4 more
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Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice. [PDF]
Sci Signal, 2019 Skewing glucocorticoid signaling to favor mineralocorticoid receptor activation is detrimental to the heart. A balancing act for the heart Stress increases the risk of dying from cardiometabolic disease.
Oakley RH +9 more
europepmc +2 more sources
Vascular cell‐specific roles of mineralocorticoid receptors in pulmonary hypertension [PDF]
Pulmonary Circulation, 2021 Abnormalities that characterize pulmonary arterial hypertension include impairment in the structure and function of pulmonary vascular endothelial and smooth muscle cells.
Divya P. Menon +10 more
doaj +2 more sources
Localization of mineralocorticoid receptors at mammalian synapses. [PDF]
PLoS ONE, 2010 In the brain, membrane associated nongenomic steroid receptors can induce fast-acting responses to ion conductance and second messenger systems of neurons.
Eric M Prager +4 more
doaj +2 more sources