Results 161 to 170 of about 21,522 (206)
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Pseudohypoaldosteronism and mineralocorticoid receptor abnormalities
The Journal of Steroid Biochemistry and Molecular Biology, 1991Pseudohypoaldosteronism is a rare inherited disease characterized by renal salt loss, hyperkalemia and metabolic acidosis despite highly elevated aldosterone values. We previously reported absent or reduced numbers of mineralocorticoid receptors in mononuclear leukocytes and defective effector mechanism as shown by no response in vitro to the ...
ARMANINI, DECIO +8 more
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Nihon rinsho. Japanese journal of clinical medicine, 2009
Recent clinical trials have indicated the utility of mineralocorticoid receptor (MR) antagonists in patients with cardiovascular and renal diseases. Experiments studies have shown that chronic treatment with aldosterone resulted in severe cardiac and renal injuries, which were ameliorated by MR antagonists.
Akira, Nishiyama +2 more
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Recent clinical trials have indicated the utility of mineralocorticoid receptor (MR) antagonists in patients with cardiovascular and renal diseases. Experiments studies have shown that chronic treatment with aldosterone resulted in severe cardiac and renal injuries, which were ameliorated by MR antagonists.
Akira, Nishiyama +2 more
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Mineralocorticoid receptor and cardiac arrhythmia
Clinical and Experimental Pharmacology and Physiology, 2013Summary Mineralocorticoid receptor (MR) activation has been shown to play a deleterious role in the development of heart disease in studies using specific MR antagonists (spironolactone, eplerenone) in both experimental models and patients. Pharmacological MR blockade attenuates the transition to heart failure (HF) in models of systolic left ...
Basile, Gravez +2 more
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Mineralocorticoid Receptors in Human Kidney
The Journal of Clinical Endocrinology & Metabolism, 1976Cytosol binding of [3H]aldosterone was measured after incubation of the hormone at 37 C with slices of human kidney obtained after surgical removal. High affinity [3H]aldosterone binding with an apparent equilibrium dissociation constant (Kd) of approximately 0.5 nM was observed to probably "mineralo-corticoid receptors." [3H]aldosterone binding of ...
D T, Matulich +3 more
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Evolution of the Mineralocorticoid Receptor
2019The mineralocorticoid receptor (MR) and its kin, the glucocorticoid receptor (GR) evolved from an ancestral corticoid receptor (CR) in a cyclostome (jawless fish) through gene duplication and divergence. Distinct MR and GR orthologs first appear in cartilaginous fishes, such as sharks, skates, rays and chimaeras.
Michael E, Baker, Yoshinao, Katsu
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Mineralocorticoid Receptors: Distribution and Activation
Heart Failure Reviews, 2005Mineralocorticoid receptors (MR) bind both mineralocorticoids and glucocorticoids with high affinity (deoxycorticosterone = corticosterone >/= aldosterone = cortisol), and are found in both Na(+) transporting epithelia (e.g. kidney, colon) and nonepithelial tissues (e.g. heart, brain).
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The role of mineralocorticoid receptor activation in kidney inflammation and fibrosis
Kidney International Supplements, 2022James M Luther
exaly
Brain Mineralocorticoid Receptor Functiona
Annals of the New York Academy of Sciences, 1994E R, de Kloet +3 more
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Cyproheptadine and Mineralocorticoid Receptors
New England Journal of Medicine, 1982ARMANINI, DECIO, KARBOWIAK I, FUNDER J.
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