Results 11 to 20 of about 2,343,081 (240)

Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology. [PDF]

Int J Mol Sci, 2018
The nuclear hormone receptor (NR) superfamily comprises approximately 50 evolutionarily conserved proteins that play major roles in gene regulation by prototypically acting as ligand-dependent transcription factors.
Sevilla LM, Pérez P.
europepmc   +2 more sources

Glucocorticoid Receptor-Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses.

Endocrinology, 2019
Mineralocorticoid and glucocorticoid receptors (MRs and GRs) constitute a functionally important dual receptor system detecting and transmitting circulating corticosteroid signals.
Rivers CA, Rogers MF, Stubbs FE, Conway-Campbell BL, Lightman SL, Pooley JR.   +5 more
europepmc   +2 more sources

Influence of allelic variations in relation to norepinephrine and mineralocorticoid receptors on psychopathic traits: a pilot study [PDF]

PeerJ, 2018
Background Past findings support a relationship between abnormalities in the amygdala and the presence of psychopathic traits. Among other genes and biomarkers relevant to the amygdala, norepinephrine and mineralocorticoid receptors might both play a ...
Guillaume Durand
doaj   +3 more sources

Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5. [PDF]

Cell Rep, 2021
Hartmann J, Bajaj T, Klengel C, Chatzinakos C, Ebert T, Dedic N, McCullough KM, Lardenoije R, Joëls M, Meijer OC, McCann KE, Dudek SM, Sarabdjitsingh RA, Daskalakis NP, Klengel T, Gassen NC, Schmidt MV, Ressler KJ.   +17 more
europepmc   +2 more sources

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

Nature Medicine, 2012
Hypertension is a cardiovascular risk factor present in over two-thirds of people over age 60 in North America; elevated blood pressure correlates with increased risk of heart attack, stroke and progression to heart and kidney failure.
Paulo Pires, Shawn B Bender, Mark Aronovitz   +2 more
exaly   +2 more sources

Comparison of stress-induced changes in adults and pups: is aldosterone the main adrenocortical stress hormone during the perinatal period in rats? [PDF]

PLoS ONE, 2013
Positive developmental impact of low stress-induced glucocorticoid levels in early development has been recognized for a long time, while possible involvement of mineralocorticoids in the stress response during the perinatal period has been neglected ...
János Varga, Szilamér Ferenczi, Krisztina J Kovács, Alexandra Garafova, Daniela Jezova, Dóra Zelena   +5 more
doaj   +4 more sources

Mineralocorticoid Receptors, Neuroinflammation and Hypertensive Encephalopathy. [PDF]

Cell Mol Neurobiol, 2019
Brocca ME, Pietranera L, de Kloet ER, De Nicola AF.   +3 more
europepmc   +2 more sources

Glucocorticoid and mineralocorticoid receptors and corticosteroid homeostasis are potential targets for endocrine-disrupting chemicals

Environment International, 2019
Endocrine-disrupting chemicals (EDCs) have received significant concern, since they ubiquitously exist in the environment and are able to induce adverse health effects on human and wildlife. Increasing evidence shows that the glucocorticoid receptor (GR)
Jianyun Zhang, Ye Yang, Weiping Liu
exaly   +3 more sources

Brain mineralocorticoid receptors in cognition and cardiovascular homeostasis. [PDF]

Steroids, 2014
Gomez-Sanchez EP.
europepmc   +2 more sources

Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone

Proceedings of the National Academy of Sciences of the United States of America, 2005
Henk Karst, Günther Schütz
exaly   +2 more sources