Results 21 to 30 of about 21,522 (206)

Mineralocorticoid receptors guide spatial and stimulus-response learning in mice. [PDF]

PLoS ONE, 2014
Adrenal corticosteroid hormones act via mineralocorticoid (MR) and glucocorticoid receptors (GR) in the brain, influencing learning and memory. MRs have been implicated in the initial behavioral response in novel situations, which includes behavioral ...
J Marit Arp, Judith P ter Horst, Sofia Kanatsou, Guillén Fernández, Marian Joëls, Harm J Krugers, Melly S Oitzl   +6 more
doaj   +1 more source

PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY

Рациональная фармакотерапия в кардиологии, 2017
The theory of chronic hyperactivation of neurohormonal systems, in particular, sympathoadrenal and renin-angiotensin-aldosterone, is the basis of modern concepts of the pathogenesis of heart failure. The medicinal blocking of these two systems has proved
O. M. Drapkina, D. U. Akasheva
doaj   +1 more source

Non-genomic Actions of Methylprednisolone Differentially Influence GABA and Glutamate Release From Isolated Nerve Terminals of the Rat Hippocampus

Frontiers in Molecular Neuroscience, 2020
Corticosteroids exert a dual role in eukaryotic cells through their action via (1) intracellular receptors (slow genomic responses), or (2) membrane-bound receptors (fast non-genomic responses).
Rafael Neiva, Rafael Neiva, Ana Caulino-Rocha, Ana Caulino-Rocha, Fátima Ferreirinha, Fátima Ferreirinha, Maria Graça Lobo, Maria Graça Lobo, Paulo Correia-de-Sá, Paulo Correia-de-Sá   +9 more
doaj   +1 more source

Comparison of stress-induced changes in adults and pups: is aldosterone the main adrenocortical stress hormone during the perinatal period in rats? [PDF]

PLoS ONE, 2013
Positive developmental impact of low stress-induced glucocorticoid levels in early development has been recognized for a long time, while possible involvement of mineralocorticoids in the stress response during the perinatal period has been neglected ...
János Varga, Szilamér Ferenczi, Krisztina J Kovács, Alexandra Garafova, Daniela Jezova, Dóra Zelena   +5 more
doaj   +1 more source

The role of mineralocorticoid receptors hyperactivation in the development of cardiorenal complications in patients with diabetes mellitus, perspective of the selective nonsteroidal mineralocorticoid receptors antagonist’s treatment: A review

Терапевтический архив, 2023
The renin-angiotensin-aldosterone system (RAAS) activation plays a key role in the chronic kidney disease (CKD) progression and in the cardiovascular complications (CVC) development in patients with diabetes mellitus (DM).
Irina N. Bobkova
doaj   +1 more source

The role of aldosterone in the development of atrial fibrillation: modern understanding of problem

Архивъ внутренней медицины, 2019
The review of literature presents modern ideas about the role of aldosterone in the development and maintenance of atrial fibrillation. It is shown that hormone takes part in all stages of the electrophysiological and structural atrial remodeling ...
N. T. Vatutin, A. N. Shevelok, I. N. Kravchenko   +2 more
doaj   +1 more source

Glucocorticoid feedback paradox: a homage to Mary Dallman

Stress, 2023
As the end product of the hypothalamus-pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone coordinate circadian activities, stress-coping, and adaptation to change.
Edo Ronald de Kloet
doaj   +1 more source

Aldosterone: Essential for Life but Damaging to the Vascular Endothelium

Biomolecules, 2023
The renin angiotensin aldosterone system is a key regulator of blood pressure. Aldosterone is the final effector of this pathway, acting predominantly via mineralocorticoid receptors. Aldosterone facilitates the conservation of sodium and, with it, water
Michael Crompton, Laura J. Skinner, Simon C. Satchell, Matthew J. Butler   +3 more
doaj   +1 more source

The effectiveness of eplerenone in clinical practice from the standpoint of evidence-based medicine (twenty years on the guard of life)

Лечащий Врач, 2023
The article focuses on the negative role of hyperaldosteronism in cardiovascular diseases and the possibility of its control when using a selective mineralocorticoid receptor antagonist – eplerenone.
A. G. Evdokimova, R. I. Stryuk, V. V. Evdokimov, A. K. Kaptaeva   +3 more
doaj   +1 more source

Treatment of Hypertension in a Child With 11Beta-Hydroxylase Deficiency: A Case Report

Journal of Pediatrics Review, 2022
Background: 11beta-hydroxylase deficiency (11βOHD) is clinically presented with external genitalia virilization in girls and precocious puberty in boys. Low renin hypertension occurs in both sexes.
Fatemeh Saffari, Banafsheh Arad
doaj