Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats
Scientific ReportsInflammation and fibrosis often occur in the kidney after acute injury, resulting in chronic kidney disease and consequent renal failure. Recent studies have indicated that lymphangiogenesis can drive renal inflammation and fibrosis in injured kidneys ...
Juan Hao +9 more
doaj +1 more source
Immune Effects of Corticosteroids in Sepsis
Frontiers in Immunology, 2018 Sepsis, a life-threatening organ dysfunction, results from a dysregulated host response to invading pathogens that may be characterized by overwhelming systemic inflammation or some sort of immune paralysis.
Nicholas Heming +6 more
doaj +1 more source
Temporal trends in initiation of mineralocorticoid receptor antagonists and risk of subsequent withdrawal in patients with heart failure: a nationwide study in
, 2021 Deewa Zahir +12 more
openalex +1 more source
Effects of mineralocorticoid receptor antagonists in heart failure with reduced ejection fraction patients with chronic obstructive pulmonary disease in
, 2021 Su Ern Yeoh +9 more
openalex +1 more source
Therapeutic potential of finerenone for diabetic cardiomyopathy: focus on the mechanisms
Diabetology & Metabolic SyndromeDiabetic cardiomyopathy (DCM) is a kind of myocardial disease that occurs in diabetes patients and cannot be explained by hypertensive heart disease, coronary atherosclerotic heart disease and other heart diseases. Its pathogenesis may be closely related
Jing Wang +6 more
doaj +1 more source
THE USE OF MINERALOCORTICOID RECEPTOR ANTAGONISTS IN THE PRE VENTION OF ATRIAL FIBRILLATION
Архивъ внутренней медицины, 2019 Atrial fibrillation (AF) is one of the most common cardiac rhythm disorders. Its prevalence is about 1 % in the general population and exceeds 7 % in individuals older than 60 years of age.
N. T. Vatutin +3 more
doaj +1 more source
Safety, Tolerability, and Pharmacokinetics of the Mineralocorticoid Receptor Modulator AZD9977 in Healthy Men: A Phase I Multiple Ascending Dose Study [PDF]
, 2019 Andrew K. Whittaker +11 more
openalex +1 more source
Hsp90 blockers inhibit adipocyte differentiation and fat mass accumulation.
PLoS ONE, 2014 Geldanamycin derivatives are benzoquinone ansamycin antibiotics that bind to Hsp90 and alter its function. The alteration of Hsp90 activity limits some cellular hormonal responses by inhibiting nuclear receptors activation. The nuclear receptors activity,
Sébastien Desarzens +4 more
doaj +1 more source
Vascular endothelial mineralocorticoid receptors and epithelial sodium channels in metabolic syndrome and related cardiovascular disease. [PDF]
J Mol Endocrinol, 2023 Jia G, Hill MA, Sowers JR.
europepmc +1 more source