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Mineralocorticoid and Apparent Mineralocorticoid Syndromes of Secondary Hypertension
Advances in Chronic Kidney Disease, 2015The mineralocorticoid aldosterone is a key hormone in the regulation of plasma volume and blood pressure in man. Excessive levels of this mineralocorticoid have been shown to mediate metabolic disorders and end-organ damage more than what can be attributed to its effects on blood pressure alone.
Sivakumar Ardhanari +4 more
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Mineralocorticoid hypertension
The Lancet, 1999Hypertension with hypokalaemia and suppression of plasma renin activity is known as mineralocorticoid hypertension. Although mineralocorticoid hypertension accounts for a small number of patients labelled as having "essential" hypertension, it is a potentially reversible cause of high blood pressure.
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Steroids, 1996
Pseudohypoaldosteronism was first described in 1958 by Cheek and Perry, who reported an infant with severe salt wasting in the absence of any renal or adrenal defect. Since then several reports have described patients affected by symptoms consistent with resistance to mineralocorticoid action.
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Pseudohypoaldosteronism was first described in 1958 by Cheek and Perry, who reported an infant with severe salt wasting in the absence of any renal or adrenal defect. Since then several reports have described patients affected by symptoms consistent with resistance to mineralocorticoid action.
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Evidence for Cortisol as the mineralocorticoid in the syndrome of apparent mineralocorticoid excess
Journal of Endocrinological Investigation, 1992The hypothesis that cortisol is the functioning mineralocorticoid in the syndrome of apparent mineralocorticoid excess was tested by suppressing its secretion with dexamethasone. The subjects were two siblings with the type 2 form of this syndrome in which the defect in the peripheral metabolism of cortisol lies predominantly in ring A reduction but ...
TEDDE, Rinaldo +3 more
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Trends in Endocrinology & Metabolism, 1998
Adrenal Glands, Vascular System and Hypertension Edited by G.P. Vinson and D.C. Anderson. Bristol, UK, Society for Endocrinology, $95.00/ pound50.00 (312 pages), ISBN 1-898099-07-3.
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Adrenal Glands, Vascular System and Hypertension Edited by G.P. Vinson and D.C. Anderson. Bristol, UK, Society for Endocrinology, $95.00/ pound50.00 (312 pages), ISBN 1-898099-07-3.
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Disorders of mineralocorticoid synthesis
Best Practice & Research Clinical Endocrinology & Metabolism, 2001Abnormalities of mineralocorticoid synthesis and/or metabolism profoundly affect the regulation of electrolyte and water balance and of blood pressure. Characteristic changes in extracellular potassium, sodium and hydrogen ion concentrations are usually diagnostic. Serious deficiency may be acquired, for example in Addison's disease, or inherited.
J M, Connell, R, Fraser, E, Davies
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Apparent mineralocorticoid excess
Trends in Endocrinology & Metabolism, 2001Apparent mineralocorticoid excess (AME) is a potentially fatal genetic disorder causing severe juvenile hypertension, pre- and postnatal growth failure, hypokalemia and low to undetectable levels of renin and aldosterone. It is caused by autosomal recessive mutations in the HSD11B2 gene, which result in a deficiency of 11 beta-hydroxysteroid ...
R C, Wilson, S, Nimkarn, M I, New
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