Results 241 to 250 of about 7,219 (278)

The Multifaceted Mineralocorticoid Receptor

Comprehensive Physiology, 2014
Abstract The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol and corticosterone, act through the structurally similar mineralocorticoid (MR) and glucocorticoid receptors (GRs). Aldosterone is crucial for fluid, electrolyte, and hemodynamic homeostasis and tissue repair; the
Elise, Gomez-Sanchez, Celso E, Gomez-Sanchez   +1 more
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Mineralocorticoid receptor antagonists

Current Hypertension Reports, 2007
With an increasingly aging population, the need for effective treatment of cardiovascular diseases (eg, heart failure, hypertension, and ischemic heart disease) cannot be overemphasized. The vital importance of mineralocorticoid receptor antagonists for treating cardiovascular conditions has only been appreciated in the last decade. The re-emergence of
Parthasarathy, Hari Krishnan, MacDonald, Thomas M.   +1 more
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Monogenic mineralocorticoid hypertension

Best Practice & Research Clinical Endocrinology & Metabolism, 2006
Monogenic mutations leading to excessive activation of the mineralocorticoid pathway result, almost always, in suppressed renin and hypertension in adult life and sometimes in hypokalaemia and alkalosis, which can be severe. In most of these syndromes, precise molecular changes in specific steroidogenic or effector genes have been identified ...
Stowasser, Michael, Gordon, Richard D.
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Apparent mineralocorticoid excess

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Apparent mineralocorticoid excess is a syndrome reflecting the absent or impaired activity of the enzyme 11β-hydroxysteroid dehydrogenase Type 2. It may be mild when the mutant enzyme retains some activity, or severe when activity is absolutely or essentially absent.
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Mineralocorticoids

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Mineralocorticoid Hypertension and Hypokalemia

Seminars in Nephrology, 2006
Mineralocorticoid hypertension is hypertension associated with the presence of hypokalemia, metabolic alkalosis, and suppression of plasma renin. Mineralocorticoid hypertension represents only 10% of patients with essential hypertension. However, its recognition is important because it is a potentially reversible cause of hypertension.
Neenoo, Khosla, Donn, Hogan
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Mineralocorticoids and blood pressure

Current Opinion in Nephrology and Hypertension, 1994
Recent observations suggest that the syndrome of mineralocorticoid excess, primary aldosteronism, may be more common than has been previously believed. Enhanced detection of this syndrome has been simplified by the development of sensitive screening techniques.
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Mineralocorticoid receptors and hypertension

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Mineralocorticoid receptors (MR) have equal affinity for the mineralocorticoid aldosterone, and the physiological glucocorticoids cortisol and corticosterone. In epithelial tissues in vivo, MR are protected against glucocorticoid occupancy by the enzyme 11 beta-hydroxysteroid dehydrogenase, allowing access by the lower circulating levels of the ...
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Mineralocorticoids and Hypertension

American Journal of Nephrology, 2008
O B, Holland, C, Gomez-Sanchez
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Mineralocorticoid Excess Syndromes

2001
Mincralocorticoid excess syndromes are characterized by overactivity of amiloridesensitive sodium channels (ASSCs) in the distal tubule and collecting duct of the kidney, and presumably in other tissues. Most of the currently recognized, and widely accepted pathophysiological sequels of that overactivity can be explained by overactivity of the renal ...
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