Results 41 to 50 of about 7,219 (278)
Sodium and mineralocorticoids in normal pregnancy [PDF]
, 1980 For many years clinicians have speculated that abnormal sodium metabolism plays an important role in the pathogenesis of hypertension. This consideration probably has been most evident in obstetrical practices directed toward preventing hypertensive ...
Nolten, Wolfram E., Ehrlich, Edward N.
core +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundThe incidence of obesity is rising, particularly among women. Microvascular dysfunction is more common with female sex, obesity, and hyperlipidemia and predicts adverse cardiovascular outcomes, but the molecular mechanisms are unclear.
Ana P. Davel +6 more
doaj +1 more source
30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor mutations [PDF]
Journal of Endocrinology, 2017 Aldosterone and the mineralocorticoid receptor (MR) are key elements for maintaining fluid and electrolyte homeostasis as well as regulation of blood pressure. Loss-of-function mutations of the MR are responsible for renal pseudohypoaldosteronism type 1 (PHA1), a rare disease of mineralocorticoid resistance presenting in the newborn with weight loss ...
Maria-Christina, Zennaro +1 more
openaire +2 more sources
Metabolic remodelling of cardiac myocytes during pregnancy: the role of mineralocorticoids [PDF]
, 2011 International audienceBackground: Pregnancy is associated with significant cardiac adaptations. The regulatory mechanisms involved in functional cardiac adaptations during pregnancy are still largely unknown.
Fouron, Jean-Claude +11 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk +10 more
wiley +1 more source
Ocular steroidome in human eyes and in eyes with complex central serous chorioretinopathy (CSCR)
Scientific Reports, 2023 The exact link between systemic and ocular endogenous corticoids (steroidome) is unclear and whether the ocular steroidome is altered in CSCR eyes is unknown.
Marta Zola +7 more
doaj +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun +7 more
wiley +1 more source
A Contemporary Approach to the Diagnosis and Management of Adrenal Insufficiency [PDF]
Endocrinology and MetabolismAdrenal insufficiency (AI) can be classified into three distinct categories based on its underlying causes: primary adrenal disorders, secondary deficiencies in adrenocorticotropin, or hypothalamic suppression from external factors, most commonly ...
Suranut Charoensri, Richard J. Auchus
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson +8 more
wiley +1 more source
Disorders of the adrenal cortex: Genetic and molecular aspects
Frontiers in Endocrinology, 2022 Adrenal cortex produces glucocorticoids, mineralocorticoids and adrenal androgens which are essential for life, supporting balance, immune response and sexual maturation.
Georgia Pitsava +4 more
doaj +1 more source