Results 121 to 130 of about 217,541 (357)

Becoming-interior : toward a nondual philosophy of design for dwelling-in-the-world : a thesis presented in partial fulfillment of the requirements for the degree of Master of Design at Massey University [PDF]

open access: yes, 2005
Martin Heidegger suggests that dwelling is an act of inhabitation, which engenders a becoming-interior of the world. The site of this dwelling is not confined to architecture, but occurs in the space between earth and sky: the world.
Archer, Jennifer
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Minimal intervention [PDF]

open access: yesBritish Dental Journal, 2004
R F, Mosedale, F J T, Burke
openaire   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Jüri Okas’ ‘specific objects’: diverging discourses in Estonian Art in the 1970s. [PDF]

open access: yes, 2008
Previously in the University eprints HAIRST pilot service at http://eprints.st-andrews.ac.uk/archive/00000367/Article 3 of 6 in issue devoted to the visual culture of the Scandinavian and Baltic region.This article will look at the early works of ...
Kurg, Andres.
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

A Modest Minimalism?

open access: yesStudia Philosophica Estonica, 2008
My aim in this paper is to present and evaluate one version of the deflationary attitude to truth, namely the Modest Account, propounded by Wolfgang Künne in his Conceptions of Truth (OUP 2003). I introduce the deflationary theories of truth in the first
Jaan Kangilaski
doaj  

Negation and the Left Periphery of the Clause in Persian Yes-No Questions: A Minimalist Approach [PDF]

open access: yesمطالعات زبان‌‌ها و گویش‌های غرب ایران, 2017
The aim of the present paper is to analyze the negative and interrogative interpretations in the yes-no questions in Persian in terms of which verb is preposed and moved to the left periphery of the clause under the influence of discourse–functional ...
Hossein Moghani
doaj  

Metasemantics, Moral Realism and Moral Doctrines [PDF]

open access: yes
In this paper, I consider the relationship between Matthew Kramer’s moral realism as a moral doctrine and expressivism, understood as a distinctly non-representationalist metasemantic theory of moral vocabulary.
Tiefensee, Christine
core  

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