Results 81 to 90 of about 217,541 (357)
Which values should be built into economic measures? [PDF]
, 2019 Many economic measures are structured to reflect ethical values. I describe three attitudes towards this: maximalism, according to which we should aim to build all relevant values into measures; minimalism, according to which we should aim to keep values
Schroeder, S. Andrew
core
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Minimizing Convex Functions with Rational Minimizers
Journal of the ACM, 2022 Given a separation oracle SO for a convex function f defined on ℝ n that has an integral minimizer inside a box with radius R , we show how to find an exact minimizer of f using at most
openaire +3 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
The Spectator in the Picture [PDF]
, 2001 This paper considers whether pictures ever implicitly represent internal spectators of the scenes they depict, and what theoretical construal to offer of their doing so.
Hopkins, Robert
core +1 more source
Annals of Pure and Applied Logic, 1989 It is shown that the real in Jensen's coding theorem can be minimal over the model to be coded. The almost-disjoint forcing part in Jensen's proof is replaced by some kind of perfect set forcing. Before giving the rather involved proof the author gives the special cases when the set to be minimally coded is a subset of \(\omega_ 1\), \(\omega_ 2\), or \
openaire +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Is Meaning Holism Compatible with Semantic Minimalism?
Studia Semiotyczne, 2019 DOI: http://doi.org/10.26333/sts.xxxi2.04 Meaning Holism and Contextualism are standardly acknowledged to be similar relativistic theories that often lead to similar troubles, in particular to issues concerning instability. On the other hand, the main
Filip Kawczyński
doaj