Results 101 to 110 of about 1,942,479 (324)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Development of Ground-testable Phase Fresnel Lenses in Silicon
, 2006 Diffractive/refractive optics, such as Phase Fresnel Lenses (PFL's), offer the potential to achieve excellent imaging performance in the x-ray and gamma-ray photon regimes.
B. Morgan +14 more
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Science and Technology of Advanced Materials, 2008 The present status of Cs-corrected TEM/STEM is described from the viewpoint of the observation of nanomaterials. Characteristic features in TEM and STEM are explained using the experimental data obtained by our group and other research groups.
Nobuo Tanaka
doaj
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Prediction of atmospheric environmental severity in Tibet based on polycarbonate (PC) aging behavior
工程科学学报The spatiotemporal distribution of atmospheric environmental severity in Tibet was evaluated and predicted based on polycarbonate (PC) chromatic aberrations.
Dequan WU +6 more
doaj +1 more source
Optical Design of the far Ultraviolet Imaging Spectrograph [PDF]
Journal of Astronomy and Space Sciences, 1998 We present the design specifications and the performance estimation of the FUVS (Far Ultraviolet Spectrograph) proposed for the observations of aurora, day/night airglow and astronomical objects on small satelltes in the spectral range of . The design of
K. S. Ryu +3 more
doaj
Active Optics in Astronomy: Freeform Mirror for the MESSIER Telescope Proposal
Mathematical and Computational Applications, 2018 Active optics techniques in astronomy provide high imaging quality. This paper is dedicated to highly deformable active optics that can generate non-axisymmetric aspheric surfaces—or freeform surfaces—by use of a minimum number of actuators ...
Gerard Rene Lemaitre +2 more
doaj +1 more source
Effect of linear energy transfer (LET) on complexity of alpha-particle-induced chromosome aberrations in human CD34+ cells. [PDF]
, 2007 The aim of this study was to assess the relative influence of linear energy transfer (LET) of α-particles on chromosome aberration complexity in the absence of significant other track structure differences.
Anderson, RM +5 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source